DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tollo and Tlr13

DIOPT Version :9

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_991389.1 Gene:Tlr13 / 279572 MGIID:3045213 Length:991 Species:Mus musculus


Alignment Length:1232 Identity:285/1232 - (23%)
Similarity:470/1232 - (38%) Gaps:399/1232 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 EHDITLVCHLRTINSELENTNFSVIQ-PQNTVRLRLECNDALFFQSSLSPDSFRSLVELRDLTIE 106
            |.||.   |:..|..::.|...::.. |:.|..|.|..|:.    ..|.|.||.:|..|.||.:|
Mouse    78 EFDIH---HVLCIRKKITNLTEAISDIPRYTTHLNLTHNEI----QVLPPWSFTNLSALVDLRLE 135

  Fly   107 YCKLGNLTDGSFRGLQELRNLTIRTHNGDWSTMSLEMASNSFVEFRQLERLDLSLNNIWLIPDGM 171
            :..:..:.:|:||||:.|..|.:..:       .::..:|||.....|:.|.||.|.|..|....
Mouse   136 WNSIWKIDEGAFRGLENLTLLNLVEN-------KIQSVNNSFEGLSSLKTLLLSHNQITHIHKDA 193

  Fly   172 VCPLKSLQHLNASYNKIQDISNFYFSASLSSRKARVCGSTLQSLDLSANKMVSL---PTAMLSAL 233
            ..||..|::|:.|.|.|.|     ||..|.:.:...|   |:.|||:.|.::.|   |.:::|  
Mouse   194 FTPLIKLKYLSLSRNNISD-----FSGILEAVQHLPC---LERLDLTNNSIMYLDHSPRSLVS-- 248

  Fly   234 GRLTHLNMAKNSMSFLADRAFEGLLSLRVVDLSANRLTSLPPELFAETKQLQEIYLRN----NSI 294
              ||||:...|.   |.:..|..|....:.:|||:|         ...|.:|.:||:.    .|:
Mouse   249 --LTHLSFEGNK---LRELNFSALSLPNLTNLSASR---------NGNKVIQNVYLKTLPQLKSL 299

  Fly   295 NVLAPGIFGE------LAELLVLDLASNELNSQWI----------------------NAATFVGL 331
            |:....|..|      |..|..:||::.||....:                      |.....|:
Mouse   300 NLSGTVIKLENLSAKHLQNLRAMDLSNWELRHGHLDMKTVCHLLGNLPKLETLVFQKNVTNAEGI 364

  Fly   332 K------RLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRN 390
            |      ||:.|||..|.               .::.|.|:..:.||        :|..|.|::.
Mouse   365 KQLAKCTRLLFLDLGQNS---------------DLIYLNDSEFNALP--------SLQKLNLNKC 406

  Fly   391 RISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPE-ALAHVQLLK 454
            ::|.|..||...|:||  .|||                      |:.||.::.|: |.:.::.|:
Mouse   407 QLSFINNRTWSSLQNL--TSLD----------------------LSHNKFKSFPDFAFSPLKHLE 447

  Fly   455 TLDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSL 519
            .|.:..|.|:::.|.:.:.|.:|..|.:....:..|.|..|.:..:|::|:|..|.::::..|:.
Mouse   448 FLSLSRNPITELNNLAFSGLFALKELNLAACWIVTIDRYSFTQFPNLEVLDLGDNNIRTLNHGTF 512

  Fly   520 QRNSQLQAIRLDGNQLKSI-AGLFTELPNLVWLNISGNRLEKFDYSHIPIGLQWLDVRANRITQL 583
            :...:||::.|..|.||.: ...|:.|.||..|::..|.|..| :.|:..||:.|     .|.:|
Mouse   513 RPLKKLQSLILSHNCLKILEPNSFSGLTNLRSLDLMYNSLSYF-HEHLFSGLEKL-----LILKL 571

  Fly   584 GNYFEIESELSLSTFDASYNLLTEITASSI--PNSVEVLYLNDNQIS------KIQPYTFFK-KP 639
            |                 :|.:|..|..::  |..:::..|....:.      ::.|..||: ..
Mouse   572 G-----------------FNKITYETTRTLQYPPFIKLKSLKQLNLEGQRHGIQVVPSNFFQGLG 619

  Fly   640 NLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNRESRTQPQLMD 704
            :|..:.|.:|                     |..::.|:.::...||..|.              
Mouse   620 SLQELLLGKN---------------------PSVFLDHHQFDPLINLTKLD-------------- 649

  Fly   705 LDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSW 769
                                                                             
Mouse   650 ----------------------------------------------------------------- 649

  Fly   770 TSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRT 834
            .|...|..|:                |||:.:.|:.|        ||||:|.|.::.:|.|....
Mouse   650 ISGTKDGDRS----------------LYLNASLFQNL--------KRLKILRLENNNLESLVPDM 690

  Fly   835 FYGLLELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAI 899
            |..|..|:|..|:.|.||.:|.                           :||.:||.|.      
Mouse   691 FSSLQSLQVFSLRFNNLKVINQ---------------------------SHLKNLKSLM------ 722

  Fly   900 TSFAVWNFLPSYLNELRLASNPWTCSCEFIDKLRDYINRHEYVVDKLK-MKCDVISGNSTQQMVI 963
                   |...|.|:|:       |:|:.:......:|..|..:..|: ..|        ||   
Mouse   723 -------FFDVYGNKLQ-------CTCDNLWFKNWSMNTEEVHIPFLRSYPC--------QQ--- 762

  Fly   964 YPGSGEPASLPVVQCSQTLPLGLDN---NFNYAEQAGGENASNATSTKMILNQPPKLDYIPILVA 1025
             ||            ||:|.:..|:   ||:..                      |:.::.....
Mouse   763 -PG------------SQSLLIDFDDAMCNFDLG----------------------KVYFLCSFSM 792

  Fly  1026 ILTAFIFVMICISLVFIFRQEMRVWCHSRFGVRLFYNAQKDVDKNEREKLFDAFVSYSSKDELFV 1090
            :|:..:|......::      ..:| :..:..|.:|..:  ..|.|::.|:|||||:|:.||.:|
Mouse   793 VLSTMVFSWFSTKMI------ASLW-YGLYICRAWYLTK--WHKTEKKFLYDAFVSFSATDEAWV 848

  Fly  1091 NEELAPMLEMG-EHRYKLCLHQRDFPVGGYLPETIVQAIDSSRRTIMVVSENFIKSEWCRFEFKS 1154
            .:||.|.||.| :..:|||||||||..|..:.|.|..||::||:|:.|||.:::.|||||.|.:.
Mouse   849 YKELVPALEQGSQTTFKLCLHQRDFEPGIDIFENIQNAINTSRKTLCVVSNHYLHSEWCRLEVQL 913

  Fly  1155 AHQSVLRDRRRRLIVIVLGEVPQKELDP--DLRLYLKTNTYLQWGDK-----LFWQKLRFAL 1209
            |...:..:.:..:|:|.|.|:|..:|..  .||..:...|::.|.|.     |||.::|.||
Mouse   914 ASMKMFYEHKDVIILIFLEEIPNYKLSSYHRLRKLINKQTFITWPDSVHQQPLFWARIRNAL 975

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR_RI <85..281 CDD:238064 58/198 (29%)
leucine-rich repeat 100..123 CDD:275380 9/22 (41%)
leucine-rich repeat 124..144 CDD:275380 2/19 (11%)
LRR_8 152..222 CDD:290566 24/69 (35%)
leucine-rich repeat 154..177 CDD:275380 9/22 (41%)
leucine-rich repeat 178..201 CDD:275380 8/22 (36%)
LRR 210..656 CDD:227223 113/497 (23%)
leucine-rich repeat 212..235 CDD:275380 8/25 (32%)
leucine-rich repeat 236..259 CDD:275380 8/22 (36%)
leucine-rich repeat 260..283 CDD:275380 4/22 (18%)
LRR_RI 276..558 CDD:238064 73/321 (23%)
leucine-rich repeat 284..307 CDD:275380 8/32 (25%)
leucine-rich repeat 308..333 CDD:275380 8/52 (15%)
leucine-rich repeat 334..357 CDD:275380 5/22 (23%)
leucine-rich repeat 358..381 CDD:275380 4/22 (18%)
leucine-rich repeat 382..405 CDD:275380 8/22 (36%)
leucine-rich repeat 406..429 CDD:275380 4/22 (18%)
leucine-rich repeat 430..452 CDD:275380 5/22 (23%)
leucine-rich repeat 453..500 CDD:275380 11/46 (24%)
leucine-rich repeat 501..521 CDD:275380 5/19 (26%)
leucine-rich repeat 525..547 CDD:275380 8/22 (36%)
leucine-rich repeat 548..573 CDD:275380 8/24 (33%)
leucine-rich repeat 604..640 CDD:275380 7/44 (16%)
leucine-rich repeat 641..688 CDD:275380 7/46 (15%)
leucine-rich repeat 689..816 CDD:275380 9/126 (7%)
LRR_8 815..875 CDD:290566 17/59 (29%)
leucine-rich repeat 817..864 CDD:275380 15/46 (33%)
LRR_8 864..921 CDD:290566 9/56 (16%)
leucine-rich repeat 865..888 CDD:275380 2/22 (9%)
leucine-rich repeat 889..910 CDD:275380 4/20 (20%)
TIR 1076..1211 CDD:214587 59/142 (42%)
Tlr13NP_991389.1 LRR 1 104..125 8/24 (33%)
leucine-rich repeat 105..128 CDD:275380 9/26 (35%)
LRR_8 106..163 CDD:290566 19/67 (28%)
LRR 2 128..149 6/20 (30%)
leucine-rich repeat 129..152 CDD:275380 9/22 (41%)
LRR 3 152..174 5/28 (18%)
leucine-rich repeat 153..175 CDD:275380 5/28 (18%)
LRR 4 175..196 7/20 (35%)
leucine-rich repeat 176..199 CDD:275380 9/22 (41%)
LRR_8 183..236 CDD:290566 20/60 (33%)
LRR_RI <192..405 CDD:238064 62/259 (24%)
LRR 5 199..220 9/25 (36%)
leucine-rich repeat 200..225 CDD:275380 9/29 (31%)
LRR 6 225..246 8/23 (35%)
leucine-rich repeat 226..248 CDD:275380 7/21 (33%)
LRR 7 248..268 8/26 (31%)
leucine-rich repeat 249..271 CDD:275380 8/24 (33%)
LRR 8 271..292 8/29 (28%)
leucine-rich repeat 272..295 CDD:275380 8/31 (26%)
LRR 9 295..315 4/19 (21%)
leucine-rich repeat 296..319 CDD:275380 5/22 (23%)
LRR 10 318..338 5/19 (26%)
LRR 11 348..368 3/19 (16%)
LRR 12 372..394 8/36 (22%)
leucine-rich repeat 373..397 CDD:275380 9/46 (20%)
LRR_8 396..456 CDD:290566 22/91 (24%)
LRR 13 397..418 7/20 (35%)
leucine-rich repeat 398..421 CDD:275380 8/22 (36%)
LRR_4 420..463 CDD:289563 15/66 (23%)
LRR 14 421..442 10/44 (23%)
leucine-rich repeat 422..445 CDD:275380 9/46 (20%)
LRR 15 445..466 5/20 (25%)
leucine-rich repeat 446..469 CDD:275380 6/22 (27%)
LRR 16 469..490 5/20 (25%)
leucine-rich repeat 470..493 CDD:275380 5/22 (23%)
LRR_8 492..552 CDD:290566 17/59 (29%)
LRR 17 493..514 5/20 (25%)
leucine-rich repeat 494..517 CDD:275380 5/22 (23%)
LRR 18 517..538 7/20 (35%)
leucine-rich repeat 518..541 CDD:275380 8/22 (36%)
LRR_8 540..602 CDD:290566 18/84 (21%)
LRR 19 541..562 7/21 (33%)
leucine-rich repeat 542..565 CDD:275380 8/23 (35%)
LRR 20 565..585 7/41 (17%)
leucine-rich repeat 566..585 CDD:275380 7/40 (18%)
LRR 21 594..617 4/22 (18%)
LRR 22 620..641 5/41 (12%)
LRR 23 644..665 9/115 (8%)
LRR_8 671..731 CDD:290566 25/99 (25%)
LRR 24 672..693 8/20 (40%)
leucine-rich repeat 673..696 CDD:275380 8/22 (36%)
LRR 25 696..716 8/46 (17%)
leucine-rich repeat 697..718 CDD:275380 9/47 (19%)
TIR 834..976 CDD:214587 59/142 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 178 1.000 Inparanoid score I4007
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
54.830

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