DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tollo and LRRTM2

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_056379.1	Gene:	LRRTM2 / 26045	HGNCID:	19409	Length:	516	Species:	Homo sapiens

Alignment Length:	528	Identity:	132/528 - (25%)
Similarity:	210/528 - (39%)	Gaps:	95/528 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 LSANKMVSLPTAMLSALG-------RLTHLNMAKNSMSF--LADRAFEGLLSLRVVDLSANRLTS 272
            |:|...:|:...||.|||       |...|....:|..|  :.:...:|.|.|   .|..|.:|.
Human    14 LAAIYAMSMVLKMLPALGMACPPKCRCEKLLFYCDSQGFHSVPNATDKGSLGL---SLRHNHITE 75

  Fly   273 LPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFVGLKRLMML 337
            |..:.||...||..::|.:|.|:.:....|..|.:|..|.|:||::  .::...||..|..|..|
Human    76 LERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKI--FYLPNTTFTQLINLQNL 138

  Fly   338 DLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQG 402
            |||.|::|.|...:|..|..||.|.|..|.:..:|..:|.|..:|..|.||.||:..:.:....|
Human   139 DLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAG 203

  Fly   403 LKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAHVQLLKTLDVGENMISQIE 467
            |..|..|.|:.|::::::....:..|.|..|.|..||:                   .|:...:|
Human   204 LIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKI-------------------SNLTCGME 249

  Fly   468 NTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDG 532
            .|..|    |..|.:|.|.:..|...||:.|.:|:||.:..|||.|:::..|.....|..:.|.|
Human   250 WTWGT----LEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSG 310

  Fly   533 NQLKSIAGLFTELPNLVWLNISGNRLEKFDYSHIPIGLQWLDV------------RANRITQLG- 584
            | |...:.....|.:  ||.....|.|.....|.|...|..|:            .:..:|.:.
Human   311 N-LWECSARICALAS--WLGSFQGRWEHSILCHSPDHTQGEDILDAVHGFQLCWNLSTTVTVMAT 372

  Fly   585 NYFEIESELSLSTFDASYNLLTEITASSIPNSVEVLYLN-------DNQI--------SKIQPYT 634
            .|.:..:|.:.....:||:    :....||.:..:....       ||.|        :....::
Human   373 TYRDPTTEYTKRISSSSYH----VGDKEIPTTAGIAVTTEEHFPEPDNAIFTQRVITGTMALLFS 433

  Fly   635 FF---------KK---PNLTRV---DLVRNRLTTLEPNALRLSPIAEDREIPEFYIGH------- 677
            ||         :|   |.|.|:   .:|:|.........|.:|.:::.....|:...|
Human   434 FFFIIFIVFISRKCCPPTLRRIRQCSMVQNHRQLRSQTRLHMSNMSDQGPYNEYEPTHEGPFIII 498

  Fly   678 NAY-ECDC 684
            |.| :|.|
Human   499 NGYGQCKC 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	21/72 (29%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566	2/4 (50%)
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223	124/490 (25%)
		leucine-rich repeat	212..235	CDD:275380	8/24 (33%)
		leucine-rich repeat	236..259	CDD:275380	4/24 (17%)
		leucine-rich repeat	260..283	CDD:275380	7/22 (32%)
		LRR_RI	276..558	CDD:238064	81/281 (29%)
		leucine-rich repeat	284..307	CDD:275380	6/22 (27%)
		leucine-rich repeat	308..333	CDD:275380	8/24 (33%)
		leucine-rich repeat	334..357	CDD:275380	10/22 (45%)
		leucine-rich repeat	358..381	CDD:275380	8/22 (36%)
		leucine-rich repeat	382..405	CDD:275380	8/22 (36%)
		leucine-rich repeat	406..429	CDD:275380	4/22 (18%)
		leucine-rich repeat	430..452	CDD:275380	5/21 (24%)
		leucine-rich repeat	453..500	CDD:275380	12/46 (26%)
		leucine-rich repeat	501..521	CDD:275380	8/19 (42%)
		leucine-rich repeat	525..547	CDD:275380	6/21 (29%)
		leucine-rich repeat	548..573	CDD:275380	7/24 (29%)
		leucine-rich repeat	604..640	CDD:275380	8/62 (13%)
		leucine-rich repeat	641..688	CDD:275380	12/55 (22%)
		leucine-rich repeat	689..816	CDD:275380
		LRR_8	815..875	CDD:290566
		leucine-rich repeat	817..864	CDD:275380
		LRR_8	864..921	CDD:290566
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
LRRTM2	NP_056379.1	LRR 1	63..83		7/22 (32%)
		LRR	<65..312	CDD:227223	82/275 (30%)
		leucine-rich repeat	66..86	CDD:275380	7/22 (32%)
		LRR 2	86..107		6/20 (30%)
		leucine-rich repeat	87..110	CDD:275380	6/22 (27%)
		LRR 3	110..131		7/22 (32%)
		leucine-rich repeat	111..134	CDD:275380	8/24 (33%)
		LRR 4	134..155		9/20 (45%)
		leucine-rich repeat	135..158	CDD:275380	10/22 (45%)
		LRR 5	158..179		7/20 (35%)
		leucine-rich repeat	159..182	CDD:275380	8/22 (36%)
		LRR 6	182..203		6/20 (30%)
		leucine-rich repeat	183..206	CDD:275380	8/22 (36%)
		LRR 7	206..227		4/20 (20%)
		leucine-rich repeat	207..230	CDD:275380	4/22 (18%)
		LRR 8	230..251		7/39 (18%)
		leucine-rich repeat	231..254	CDD:275380	8/41 (20%)
		LRR 9	254..275		8/24 (33%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		LRR 10	278..299		8/20 (40%)
		leucine-rich repeat	279..300	CDD:275380	8/20 (40%)
		PCC	284..>351	CDD:188093	19/69 (28%)
		Involved in DLG4-binding. /evidence=ECO:0000250	513..516
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910