DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and Tlr2

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	XP_006501523.1	Gene:	Tlr2 / 24088	MGIID:	1346060	Length:	794	Species:	Mus musculus

Alignment Length:	1000	Identity:	227/1000 - (22%)
Similarity:	380/1000 - (38%)	Gaps:	304/1000 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 VVDLSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAA 326
            |.|..:...||:|..|.|..|.|.   |..|.|..:..|.....|.|.||.|.|:.:|:  |...
Mouse    45 VCDGRSRSFTSIPSGLTAAMKSLD---LSFNKITYIGHGDLRACANLQVLMLKSSRINT--IEGD 104

  Fly   327 TFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQL-PGGIFADLTNLHTLILSRN 390
            .|..|..|..||||.|.:|.|.:..|.||:||:.|.|..|....| ...:|.:||||.||
Mouse   105 AFYSLGSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTL----- 164

  Fly   391 RISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAHVQLLKT 455
            ||..:|               .|:.|.|:|...|.:.::|:                     :|.
Mouse   165 RIGNVE---------------TFSEIRRIDFAGLTSLNELE---------------------IKA 193

  Fly   456 LDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVF------DRMSSLQILNLSQNKLKSI 514
            |.: .|..||          ||..:|...:...|:....|      |.:||::.|.|....|...
Mouse   194 LSL-RNYQSQ----------SLKSIRDIHHLTLHLSESAFLLEIFADILSSVRYLELRDTNLARF 247

  Fly   515 EAGSL---QRNSQLQAIRLDG--------NQLKSIAGLFTELPNLVWLNISGNRLEKFDYSHIPI 568
            :...|   :.:|.::.:...|        |:|..:.....||..:.:.:.:.|.|..|:.|...:
Mouse   248 QFSPLPVDEVSSPMKKLAFRGSVLTDESFNELLKLLRYILELSEVEFDDCTLNGLGDFNPSESDV 312

  Fly   569 -----GLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIPNSVEVLYLNDNQIS 628
                 .::.:.:|...|.|...:::      |||.   |:||.::...::.||...|.
Mouse   313 VSELGKVETVTIRRLHIPQFYLFYD------LSTV---YSLLEKVKRITVENSKVFLV------- 361

  Fly   629 KIQPYTFFKK-PNLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKV 692
               |.:|.:. .:|..:||..|.:.                   |.|:.::|    |...|
Mouse   362 ---PCSFSQHLKSLEFLDLSENLMV-------------------EEYLKNSA----CKGAW---- 396

  Fly   693 NRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMEC 757
                 ...|.:.|.|.|.|.....|...::|
Mouse   397 -----PSLQTLVLSQNHLRSMQKTGEILLTL---------------------------------- 422

  Fly   758 PDRCSCYHDQSWTSNVVDCSRASYEQTLPSHIPM-DSTQLYLDGNNFRELQSHAFIGRKRLKVLH 821
                     ::.||  :|.||.::.       || ||.|                 ..::::.|:
Mouse   423 ---------KNLTS--LDISRNTFH-------PMPDSCQ-----------------WPEKMRFLN 452

  Fly   822 LNHSRIEVLHN---RTFYGLLELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIATI-DTLT 882
            |:.:.|.|:..   :|      ||||.:.:|.|.:.:    ..|..|||||:..|.:.|: |...
Mouse   453 LSSTGIRVVKTCIPQT------LEVLDVSNNNLDSFS----LFLPRLQELYISRNKLKTLPDASL 507

  Fly   883 FTHLYHLKILRLDHNAITSFAVWNFLPSY--LNELRLASNPWTCSCEFIDKLRDYINRHEYVVDK 945
            |..|.   ::::..||:::|:. :.|.|:  |..|....|.:.||||.:               .
Mouse   508 FPVLL---VMKIRENAVSTFSK-DQLGSFPKLETLEAGDNHFVCSCELL---------------S 553

  Fly   946 LKMKCDVISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNNFNYAEQAGGENASNATSTKMI 1010
            ..|:...::    |.:|.:|.|                                         .:
Mouse   554 FTMETPALA----QILVDWPDS-----------------------------------------YL 573

  Fly  1011 LNQPPKL------DYIPILVAILTAFIFVMICISLVFIFRQEMRVWCHSRFG---VRLFY---NA 1063
            .:.||:|      |..|.::....|.:...:|.:|:.:... :...||...|   :|:.:   .|
Mouse   574 CDSPPRLHGHRLQDARPSVLECHQAALVSGVCCALLLLILL-VGALCHHFHGLWYLRMMWAWLQA 637

  Fly  1064 QKDVDKNE-REKLFDAFVSYSSKDELFVNEELAPMLEMGEHRYKLCLHQRDFPVGGYLPETIVQA 1127
            ::...|.. |:..:|||||||.:|..:|...:...||..:..:|||||:|||..|.::.:.|:.:
Mouse   638 KRKPKKAPCRDVCYDAFVSYSEQDSHWVENLMVQQLENSDPPFKLCLHKRDFVPGKWIIDNIIDS 702

  Fly  1128 IDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQKELDP---DLRLYLK 1189
            |:.|.:|:.|:||||::||||::|...:|..:..:.....|:::|..:.:|.:..   .||..:.
Mouse   703 IEKSHKTVFVLSENFVRSEWCKYELDFSHFRLFDENNDAAILVLLEPIERKAIPQRFCKLRKIMN 767

  Fly  1190 TNTYLQW-----GDKLFWQKLRFAL 1209
            |.|||:|     ..::||..||.|:
Mouse   768 TKTYLEWPLDEGQQEVFWVNLRTAI 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	7/18 (39%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223	101/417 (24%)
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380
		leucine-rich repeat	260..283	CDD:275380	7/20 (35%)
		LRR_RI	276..558	CDD:238064	75/299 (25%)
		leucine-rich repeat	284..307	CDD:275380	5/22 (23%)
		leucine-rich repeat	308..333	CDD:275380	9/24 (38%)
		leucine-rich repeat	334..357	CDD:275380	11/22 (50%)
		leucine-rich repeat	358..381	CDD:275380	7/23 (30%)
		leucine-rich repeat	382..405	CDD:275380	6/22 (27%)
		leucine-rich repeat	406..429	CDD:275380	5/22 (23%)
		leucine-rich repeat	430..452	CDD:275380	1/21 (5%)
		leucine-rich repeat	453..500	CDD:275380	11/52 (21%)
		leucine-rich repeat	501..521	CDD:275380	4/22 (18%)
		leucine-rich repeat	525..547	CDD:275380	5/29 (17%)
		leucine-rich repeat	548..573	CDD:275380	4/29 (14%)
		leucine-rich repeat	604..640	CDD:275380	7/36 (19%)
		leucine-rich repeat	641..688	CDD:275380	8/46 (17%)
		leucine-rich repeat	689..816	CDD:275380	17/127 (13%)
		LRR_8	815..875	CDD:290566	18/62 (29%)
		leucine-rich repeat	817..864	CDD:275380	12/49 (24%)
		LRR_8	864..921	CDD:290566	17/59 (29%)
		leucine-rich repeat	865..888	CDD:275380	10/23 (43%)
		leucine-rich repeat	889..910	CDD:275380	4/20 (20%)
		TIR	1076..1211	CDD:214587	50/141 (35%)
Tlr2	XP_006501523.1	internalin_A	<58..>259	CDD:380193	68/257 (26%)
		leucine-rich repeat	65..87	CDD:275378	6/24 (25%)
		LRR_8	87..145	CDD:338972	24/59 (41%)
		leucine-rich repeat	88..111	CDD:275378	9/24 (38%)
		leucine-rich repeat	112..135	CDD:275378	11/22 (50%)
		leucine-rich repeat	136..160	CDD:275378	7/23 (30%)
		leucine-rich repeat	186..212	CDD:275380	9/57 (16%)
		leucine-rich repeat	213..233	CDD:275380	3/19 (16%)
		PRK15370	<350..>568	CDD:185268	68/361 (19%)
		leucine-rich repeat	372..398	CDD:275380	9/57 (16%)
		leucine-rich repeat	399..424	CDD:275380	7/67 (10%)
		leucine-rich repeat	448..468	CDD:275380	4/19 (21%)
		leucine-rich repeat	469..488	CDD:275380	7/22 (32%)
		leucine-rich repeat	489..510	CDD:275380	9/20 (45%)
		leucine-rich repeat	511..534	CDD:275380	6/26 (23%)
		TPKR_C2	543..596	CDD:387596	15/112 (13%)
		TIR	650..794	CDD:214587	50/142 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820