DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tollo and Lrrc66

DIOPT Version :10

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_705796.1 Gene:Lrrc66 / 231296 MGIID:2387634 Length:872 Species:Mus musculus


Alignment Length:853 Identity:174/853 - (20%)
Similarity:291/853 - (34%) Gaps:278/853 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   133 NGD----WSTM-----SLEMASNSFVEFRQL--------------ERLDLSLNNIWLIPDGMVCP 174
            |||    ||::     :.:....||..||.|              :|....::.:.|.|      
Mouse    39 NGDLLVNWSSIRHVSQNTDAMDRSFYFFRVLFQPHTQKERHIKPPDRTHHRISKVTLDP------ 97

  Fly   175 LKSLQHLNASYNKIQDISN---FYFSASL----SSRKARVCGST------LQSLDLSANKMVSLP 226
               |.||:|.  :|.::||   .|||...    ||.:.|..|.:      ||.|.|..|::...|
Mouse    98 ---LAHLHAL--EILNLSNKAIHYFSLDQPLPPSSHQKRHGGHSHSRLPRLQVLILQRNQLSGTP 157

  Fly   227 TAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLRVVDLSANRLTSLPPELFAETKQLQEIYLRN 291
            .. |..|..|..|:::.|.:..:....|.|.|.|..:.|.:|::.::.|:.|...|:||.:.||:
Mouse   158 KG-LWKLKSLRSLDLSFNRIVHIGLSDFHGCLQLESIYLKSNKICTIHPKAFKGLKKLQVVDLRS 221

  Fly   292 NSINVLAPGIFGELAEL--LVLDLASNE-------LNSQWINAATFVGLKRLMMLDLSANKISRL 347
            |::..|.| |.....||  |.|.||.|:       :|.|.|.::::..:.:.:......||....
Mouse   222 NALTTLVP-IVTIALELPHLELGLADNQWQCSESNVNFQNITSSSWREIWKAICNMSVENKRPNA 285

  Fly   348 EAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQGL-KNLLVLSL 411
            |.|        ||.|..|.::      :.:..::|.:||.|:      .:|...|: .:|..|..
Mouse   286 ETH--------QIRKSRDTHL------LLSPPSDLKSLIQSK------AERPQAGMDMHLSALGK 330

  Fly   412 D----FNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAHVQLLKTLDV-------------- 458
            :    :..:..|..:|.|.....||..:.|.| ...|.||   :|...|.|              
Mouse   331 EAKDGYGDLRGMWPQSPVELRDSQDEQVTDRK-DDKPPAL---ELAICLSVFITFVVAFCLGAFA 391

  Fly   459 ------------------GENMIS--------------QIENTSITQLESLYGLRMTENS----- 486
                              .:|..|              :.:.|.:.|  :.:.|.::||.     
Mouse   392 RPYIDRLRQQRCSNKRPGSDNAYSNKGFHGDIEGAQHMEYQGTDLHQ--TTHHLHLSENQNPSWV 454

  Fly   487 ---LTHIRRGVFDRMSSLQILNLSQNKLKS--IEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELP 546
               :.|         |::|    |:..|.|  .:.|..|...||:    |.|:.:|  |....||
Mouse   455 AEPIPH---------SAVQ----SEQMLGSNGTDPGHQQSPEQLK----DSNESRS--GDSIVLP 500

  Fly   547 NLVWLNISGNRLEKFDYSHIPI-GLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEI-T 609
                   ||      ..:|:.: ||...|.. ..|:.:.::.:...|....|....|:|:.:: .
Mouse   501 -------SG------PVAHLALHGLPNADAH-KAISPVQHHHDFLEEAHYDTVAQEYSLIDDVMD 551

  Fly   610 ASSI-------PNSVE---------------------VLYLN----------------------- 623
            .|||       |:|||                     :.:.|                       
Mouse   552 RSSITGPLGTFPSSVESRRDDLHPSQPRDVVASFSKTLAHANTREAEGSMETGCPEPLGAMDSQM 616

  Fly   624 ----DNQISKIQPYTFFKKPNLTRVDLVRNRLTTL-------EPNALRL-------------SPI 664
                :.|:|........::|:...|| ...||:.:       :|.:||.             .|:
Mouse   617 GSSEERQVSNSIRELATQQPSFQGVD-AEERLSHVYSEVLHNDPPSLRPRWGSGHYVIPATGEPV 680

  Fly   665 AEDREIPEFYIGHNAYECDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHV-------- 721
            ..|......|.....||.|.:...|..::.|.....:.:..:|....   ..|:|..        
Mouse   681 ERDAPFDPHYDLVTNYESDSDEGSLFTLSSEGSEDTRSLAEEQASVE---NDGTSQPLPSRNLGE 742

  Fly   722 ---SLIEAKSDDFLCKYASHCFALCHCCDFQACDCK---MECPDRCSCYHDQSWTSNVVDCSRAS 780
               |:..|:|.:.|...     .:...|:.|....:   :..||.|.|..:|...|:.:|....|
Mouse   743 YKDSVTSAESVEDLTSQ-----RIPEKCEAQEAHLRNTLISGPDSCVCETNQENDSSSLDPENRS 802

  Fly   781 YEQTLPSH 788
            ....||.|
Mouse   803 TWPQLPGH 810

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR 54..400 CDD:443914 78/311 (25%)
leucine-rich repeat 100..123 CDD:275380
leucine-rich repeat 124..144 CDD:275380 5/19 (26%)
leucine-rich repeat 154..177 CDD:275380 4/36 (11%)
leucine-rich repeat 178..201 CDD:275380 10/29 (34%)
leucine-rich repeat 212..235 CDD:275380 8/22 (36%)
leucine-rich repeat 236..259 CDD:275380 5/22 (23%)
LRR 239..634 CDD:443914 102/521 (20%)
leucine-rich repeat 260..283 CDD:275380 5/22 (23%)
leucine-rich repeat 284..307 CDD:275380 8/22 (36%)
leucine-rich repeat 308..333 CDD:275380 9/33 (27%)
leucine-rich repeat 334..357 CDD:275380 4/22 (18%)
leucine-rich repeat 358..381 CDD:275380 4/22 (18%)
leucine-rich repeat 382..405 CDD:275380 6/23 (26%)
leucine-rich repeat 406..429 CDD:275380 5/26 (19%)
leucine-rich repeat 430..452 CDD:275380 7/21 (33%)
leucine-rich repeat 453..500 CDD:275380 10/100 (10%)
leucine-rich repeat 501..521 CDD:275380 5/21 (24%)
leucine-rich repeat 525..547 CDD:275380 6/21 (29%)
leucine-rich repeat 548..573 CDD:275380 5/25 (20%)
leucine-rich repeat 604..640 CDD:275380 11/91 (12%)
LRR_8 616..>660 CDD:404697 12/98 (12%)
leucine-rich repeat 641..688 CDD:275380 13/66 (20%)
leucine-rich repeat 689..816 CDD:275380 22/114 (19%)
LRR <794..>920 CDD:443914
leucine-rich repeat 817..864 CDD:275380
leucine-rich repeat 865..888 CDD:275380
leucine-rich repeat 889..910 CDD:275380
TIR 1076..1211 CDD:214587
Lrrc66NP_705796.1 LRR <98..>263 CDD:443914 52/168 (31%)
leucine-rich repeat 104..142 CDD:275380 10/39 (26%)
LRR 1 142..164 7/22 (32%)
leucine-rich repeat 143..165 CDD:275380 8/22 (36%)
LRR 2 165..186 4/20 (20%)
leucine-rich repeat 166..189 CDD:275380 5/22 (23%)
LRR 3 189..210 5/20 (25%)
leucine-rich repeat 190..213 CDD:275380 5/22 (23%)
LRR 4 213..234 8/21 (38%)
LRR 5 239..259 6/19 (32%)
leucine-rich repeat 240..263 CDD:275380 8/22 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 339..363 7/24 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 467..501 12/46 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 560..579 4/18 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 695..761 12/73 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 776..872 11/35 (31%)
Blue background indicates that the domain is not in the aligned region.

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