DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tollo and Nrros

DIOPT Version :9

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_001334110.1 Gene:Nrros / 224109 MGIID:2445095 Length:693 Species:Mus musculus


Alignment Length:688 Identity:158/688 - (22%)
Similarity:275/688 - (39%) Gaps:156/688 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    87 SSLSPDSFRSLVELRDLTIEYCKLGNLTDGSFRGLQELRNLTIRTHNGDWSTMSLEMASNSFVEF 151
            |||.|.|       |.|.::...|.:|.:.|.:....|.||::.:.:.|      .::..:|.|.
Mouse    53 SSLPPHS-------RMLILDANPLKDLWNHSLQAYPRLENLSLHSCHLD------RISHYAFREQ 104

  Fly   152 RQLERLDLSLNNIWLIPDGMVCPLKSLQHLNASYNKIQDISNFYFSASLSSRKARVCGSTLQSLD 216
            ..|..|.|:.|                 .|:.:|.:        .:|:|.:    :.|  |:.||
Mouse   105 GHLRNLVLADN-----------------RLSENYKE--------SAAALHT----LLG--LRRLD 138

  Fly   217 LSANKMV-SLPTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLRVVDLSANRLTSLPPELFAE 280
            ||.|.:. .:...||..|..|..:::|:|::..|.|..||||..|..:||..|.:..:....|..
Mouse   139 LSGNSLTEDMAALMLQNLSSLEVVSLARNTLMRLDDSIFEGLEHLVELDLQRNYIFEIEGGAFDG 203

  Fly   281 TKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFVGLKRLMMLDLSANKIS 345
            ..:|:.:.|..|::..:   :...|.:|..|:::.|.|  :|..||.......|.:||||.|:: 
Mouse   204 LTELRRLNLAYNNLPCI---VDFSLTQLRFLNVSYNIL--EWFLAAREEVAFELEILDLSHNQL- 262

  Fly   346 RLEAHIFRPL----ASLQILKLEDNYIDQLPGGIFADLTNLHT--------LILSRN-----RIS 393
                 :|.||    ..|..|.|:||.:     |.:.:|.|..:        |::..|     .::
Mouse   263 -----LFFPLLPQCGKLHTLLLQDNNM-----GFYRELYNTSSPQEMVAQFLLVDGNVTNITTVN 317

  Fly   394 VIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAHVQ------L 452
            :.|:.:...|..|..|.:..|:...:....|.....|..|:||.|.|:     :.|::      .
Mouse   318 LWEEFSSSDLSALRFLDMSQNQFRHLPDGFLKKTPSLSHLNLNQNCLK-----MLHIREHEPPGA 377

  Fly   453 LKTLDVGENMISQIE-NTSIT-QLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSI- 514
            |..||:..|.::::. ...:| .|.:|....::.|.|..:..|:||..||:..:::|.|::... 
Mouse   378 LTELDLSHNQLAELHLAPGLTGSLRNLRVFNLSSNQLLGVPTGLFDNASSITTIDMSHNQISLCP 442

  Fly   515 -----------EAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISGNRLEKFDYSHIPI 568
                       .....:....|:::.|||..||::.....:..:|..|::|.|    :...:..|
Mouse   443 QMVPVDWEGPPSCVDFRNMGSLRSLSLDGCGLKALQDCPFQGTSLTHLDLSSN----WGVLNGSI 503

  Fly   569 GLQW-----LDVRANRITQLGNYFEIESELSLSTF------DASYNLLTEITASSIPNSVEVLYL 622
            ...|     |.|.:.|...||:.   .:|:..|.|      |.|.|.||     |.|.       
Mouse   504 SPLWAVAPTLQVLSLRDVGLGSG---AAEMDFSAFGNLRALDLSGNSLT-----SFPK------- 553

  Fly   623 NDNQISKIQPYTFFKKPNLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYECDCNLD 687
                        |.....|..:||.||.||.|....:...|:   |.:...|:..|.|:| |.::
Mouse   554 ------------FKGSLALRTLDLRRNSLTALPQRVVSEQPL---RGLQTIYLSQNPYDC-CGVE 602

  Fly   688 WLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIE 725
            ....:.:..:|   :.||..:.|.|:    |..|.::|
Mouse   603 GWGALQQHFKT---VADLSMVTCNLS----SKIVRVVE 633

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR_RI <85..281 CDD:238064 48/194 (25%)
leucine-rich repeat 100..123 CDD:275380 5/22 (23%)
leucine-rich repeat 124..144 CDD:275380 4/19 (21%)
LRR_8 152..222 CDD:290566 15/69 (22%)
leucine-rich repeat 154..177 CDD:275380 4/22 (18%)
leucine-rich repeat 178..201 CDD:275380 3/22 (14%)
LRR 210..656 CDD:227223 118/494 (24%)
leucine-rich repeat 212..235 CDD:275380 9/23 (39%)
leucine-rich repeat 236..259 CDD:275380 9/22 (41%)
leucine-rich repeat 260..283 CDD:275380 5/22 (23%)
LRR_RI 276..558 CDD:238064 70/318 (22%)
leucine-rich repeat 284..307 CDD:275380 4/22 (18%)
leucine-rich repeat 308..333 CDD:275380 7/24 (29%)
leucine-rich repeat 334..357 CDD:275380 9/26 (35%)
leucine-rich repeat 358..381 CDD:275380 7/22 (32%)
leucine-rich repeat 382..405 CDD:275380 4/35 (11%)
leucine-rich repeat 406..429 CDD:275380 4/22 (18%)
leucine-rich repeat 430..452 CDD:275380 7/27 (26%)
leucine-rich repeat 453..500 CDD:275380 12/48 (25%)
leucine-rich repeat 501..521 CDD:275380 2/31 (6%)
leucine-rich repeat 525..547 CDD:275380 6/21 (29%)
leucine-rich repeat 548..573 CDD:275380 6/29 (21%)
leucine-rich repeat 604..640 CDD:275380 5/35 (14%)
leucine-rich repeat 641..688 CDD:275380 15/46 (33%)
leucine-rich repeat 689..816 CDD:275380 8/37 (22%)
LRR_8 815..875 CDD:290566
leucine-rich repeat 817..864 CDD:275380
LRR_8 864..921 CDD:290566
leucine-rich repeat 865..888 CDD:275380
leucine-rich repeat 889..910 CDD:275380
TIR 1076..1211 CDD:214587
NrrosNP_001334110.1 LRR 1. /evidence=ECO:0000255 58..79 6/27 (22%)
PLN00113 60..>439 CDD:215061 102/436 (23%)
leucine-rich repeat 60..82 CDD:275380 5/21 (24%)
LRR 2. /evidence=ECO:0000255 82..103 5/26 (19%)
leucine-rich repeat 83..106 CDD:275380 6/28 (21%)
LRR 3. /evidence=ECO:0000255 106..127 6/45 (13%)
leucine-rich repeat 107..133 CDD:275380 8/54 (15%)
LRR 4. /evidence=ECO:0000255 133..155 9/23 (39%)
leucine-rich repeat 134..158 CDD:275380 9/23 (39%)
LRR_8 157..217 CDD:404697 17/59 (29%)
LRR 5. /evidence=ECO:0000255 158..179 6/20 (30%)
leucine-rich repeat 159..182 CDD:275380 9/22 (41%)
LRR 6. /evidence=ECO:0000255 182..203 5/20 (25%)
leucine-rich repeat 183..206 CDD:275380 5/22 (23%)
LRR 7. /evidence=ECO:0000255 206..227 4/23 (17%)
leucine-rich repeat 207..251 CDD:275380 11/48 (23%)
LRR 8. /evidence=ECO:0000255 228..239 4/12 (33%)
leucine-rich repeat 230..249 CDD:275380 6/20 (30%)
LRR 9. /evidence=ECO:0000255 251..272 9/26 (35%)
leucine-rich repeat 252..273 CDD:275380 9/26 (35%)
LRR 10. /evidence=ECO:0000255 273..294 8/25 (32%)
leucine-rich repeat 274..329 CDD:275380 12/59 (20%)
PLN00113 309..>638 CDD:215061 81/372 (22%)
LRR 11. /evidence=ECO:0000255 329..350 4/20 (20%)
leucine-rich repeat 330..353 CDD:275380 4/22 (18%)
LRR 12. /evidence=ECO:0000255 353..374 7/25 (28%)
leucine-rich repeat 354..377 CDD:275380 7/27 (26%)
LRR 13. /evidence=ECO:0000255 377..398 4/20 (20%)
leucine-rich repeat 378..403 CDD:275380 6/24 (25%)
LRR 14. /evidence=ECO:0000255 403..424 5/20 (25%)
leucine-rich repeat 404..427 CDD:275380 6/22 (27%)
LRR 15. /evidence=ECO:0000255 427..448 3/20 (15%)
leucine-rich repeat 428..463 CDD:275380 2/34 (6%)
LRR 16. /evidence=ECO:0000255 463..484 6/20 (30%)
leucine-rich repeat 464..486 CDD:275380 6/21 (29%)
LRR 17. /evidence=ECO:0000255 486..507 5/24 (21%)
leucine-rich repeat 487..512 CDD:275380 6/28 (21%)
LRR 18. /evidence=ECO:0000255 512..533 6/23 (26%)
leucine-rich repeat 513..537 CDD:275380 8/26 (31%)
LRR 19. /evidence=ECO:0000255 537..558 8/44 (18%)
leucine-rich repeat 538..559 CDD:275380 8/44 (18%)
LRR 20. /evidence=ECO:0000255 559..580 8/20 (40%)
LRR 21. /evidence=ECO:0000255 585..605 5/20 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.