DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tollo and Tlr6

DIOPT Version :9

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:XP_030110224.1 Gene:Tlr6 / 21899 MGIID:1341296 Length:806 Species:Mus musculus


Alignment Length:1075 Identity:237/1075 - (22%)
Similarity:389/1075 - (36%) Gaps:346/1075 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   182 NASYNKIQDISNFYFSASLSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSM 246
            |.|.::...:.:|:|          ||                   |:...:|.:|..:....||
Mouse    11 NMSQDRKPIVGSFHF----------VC-------------------ALALIVGSMTPFSNELESM 46

  Fly   247 SFLADRAFEGLLSLRVVDLSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVL 311
                            ||.|...||.:|.:|...||.|.   |..|||:.|.......|:||.||
Mouse    47 ----------------VDYSNRNLTHVPKDLPPRTKALS---LSQNSISELRMPDISFLSELRVL 92

  Fly   312 DLASNELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIF 376
            .|:.|.:.|  ::...|:..:.|..||:|.|::..:..   .|:|||:.|.|..|..|.||  :.
Mouse    93 RLSHNRIRS--LDFHVFLFNQDLEYLDVSHNRLQNISC---CPMASLRHLDLSFNDFDVLP--VC 150

  Fly   377 ADLTNLHTLILSRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQ 441
            .:..||..|             |..||.......||...::.              |||:...|.
Mouse   151 KEFGNLTKL-------------TFLGLSAAKFRQLDLLPVAH--------------LHLSCILLD 188

  Fly   442 AVPEALAHVQLLKTLDVGENMISQIENTSITQL----ESLYGLR--MTENSLTHIRRGVFDRMSS 500
            .|.   .|::      .||....||.||::..|    .||:.::  |:.|:|.|           
Mouse   189 LVS---YHIK------GGETESLQIPNTTVLHLVFHPNSLFSVQVNMSVNALGH----------- 233

  Fly   501 LQILNLSQNK---------LKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISG- 555
            ||:.|:..|.         |..:..|....|..||.|.........:...|...| :.:|||.. 
Mouse   234 LQLSNIKLNDENCQRLMTFLSELTRGPTLLNVTLQHIETTWKCSVKLFQFFWPRP-VEYLNIYNL 297

  Fly   556 ---NRLEKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIPNSV 617
               .|:::.::::....|:.|.:.           .:::::.|.:.:|.|::..|:       ::
Mouse   298 TITERIDREEFTYSETALKSLMIE-----------HVKNQVFLFSKEALYSVFAEM-------NI 344

  Fly   618 EVLYLNDNQ-ISKIQP-----YTFFKKPNLTRVDLVRNRLTTLEPNALRLSPIAEDRE-IPEFYI 675
            ::|.::|.. |..:.|     :||.........|.|....:||:    ||..:...|. :..|: 
Mouse   345 KMLSISDTPFIHMVCPPSPSSFTFLNFTQNVFTDSVFQGCSTLK----RLQTLILQRNGLKNFF- 404

  Fly   676 GHNAYECDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCF 740
                           ||...::....|..||              |||....         ||.:
Mouse   405 ---------------KVALMTKNMSSLETLD--------------VSLNSLN---------SHAY 431

  Fly   741 ALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFRE 805
                              || :|    :|..::               :.::.:...|.|:.||.
Mouse   432 ------------------DR-TC----AWAESI---------------LVLNLSSNMLTGSVFRC 458

  Fly   806 LQSHAFIGRKRLKVLHLNHSRI-----EVLHNRTFYGLLELEVLQLQSNQLKALNG-NEFQGLDN 864
            |.       .::|||.|:::||     :|.|      |..|:.|.:.||.|..|.| ..|..   
Mouse   459 LP-------PKVKVLDLHNNRIMSIPKDVTH------LQALQELNVASNSLTDLPGCGAFSS--- 507

  Fly   865 LQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAITSFAVWNFLPSYLN--ELRLASNPWTCSCE 927
                                    |.:|.:|||:: |....:|..|..|  .|...:||:.|:||
Mouse   508 ------------------------LSVLVIDHNSV-SHPSEDFFQSCQNIRSLTAGNNPFQCTCE 547

  Fly   928 FIDKLRDYINRHEYVVDKLKMKCDVISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNNFNY 992
                |||::....:|..      :|:.|........||.|.:..:|.....|   ||..|.    
Mouse   548 ----LRDFVKNIGWVAR------EVVEGWPDSYRCDYPESSKGTALRDFHMS---PLSCDT---- 595

  Fly   993 AEQAGGENASNATSTKMILNQPPKLDYIPILVAILTAFIFVMICISLVFI--------FRQEMRV 1049
                                         :|:.:......:::.::..|:        :.:.:..
Mouse   596 -----------------------------VLLTVTIGATMLVLAVTGAFLCLYFDLPWYVRMLCQ 631

  Fly  1050 WCHSRFGVRLFYNAQKDVDKNEREKLFDAFVSYSSKDELFVNEELAPMLEMGEHRYKLCLHQRDF 1114
            |..:|...|     ...:::.:|...|.||||||..|..:|..||.|.||..:.|  :|||:|:|
Mouse   632 WTQTRHRAR-----HIPLEELQRNLQFHAFVSYSEHDSAWVKNELLPNLEKDDIR--VCLHERNF 689

  Fly  1115 PVGGYLPETIVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQKE 1179
            ..|..:.|.|:..|:.|.:.|.|:|.:||:||||.:|...||.::..:....||:|:|..:.|..
Mouse   690 VPGKSIVENIINFIEKSYKAIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLILILLEPILQNN 754

  Fly  1180 LDP---DLRLYLKTNTYLQWGDK-----LFWQKLR 1206
            :..   .||..:...|||:|..:     |||..||
Mouse   755 IPSRYHKLRALMAQRTYLEWPTEKGKRGLFWANLR 789

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR_RI <85..281 CDD:238064 18/98 (18%)
leucine-rich repeat 100..123 CDD:275380
leucine-rich repeat 124..144 CDD:275380
LRR_8 152..222 CDD:290566 6/39 (15%)
leucine-rich repeat 154..177 CDD:275380
leucine-rich repeat 178..201 CDD:275380 4/18 (22%)
LRR 210..656 CDD:227223 103/470 (22%)
leucine-rich repeat 212..235 CDD:275380 1/22 (5%)
leucine-rich repeat 236..259 CDD:275380 3/22 (14%)
leucine-rich repeat 260..283 CDD:275380 8/22 (36%)
LRR_RI 276..558 CDD:238064 75/300 (25%)
leucine-rich repeat 284..307 CDD:275380 7/22 (32%)
leucine-rich repeat 308..333 CDD:275380 7/24 (29%)
leucine-rich repeat 334..357 CDD:275380 6/22 (27%)
leucine-rich repeat 358..381 CDD:275380 7/22 (32%)
leucine-rich repeat 382..405 CDD:275380 5/22 (23%)
leucine-rich repeat 406..429 CDD:275380 2/22 (9%)
leucine-rich repeat 430..452 CDD:275380 6/21 (29%)
leucine-rich repeat 453..500 CDD:275380 13/52 (25%)
leucine-rich repeat 501..521 CDD:275380 6/28 (21%)
leucine-rich repeat 525..547 CDD:275380 4/21 (19%)
leucine-rich repeat 548..573 CDD:275380 5/28 (18%)
leucine-rich repeat 604..640 CDD:275380 7/41 (17%)
leucine-rich repeat 641..688 CDD:275380 8/47 (17%)
leucine-rich repeat 689..816 CDD:275380 19/126 (15%)
LRR_8 815..875 CDD:290566 17/65 (26%)
leucine-rich repeat 817..864 CDD:275380 17/52 (33%)
LRR_8 864..921 CDD:290566 10/58 (17%)
leucine-rich repeat 865..888 CDD:275380 0/22 (0%)
leucine-rich repeat 889..910 CDD:275380 7/20 (35%)
TIR 1076..1211 CDD:214587 53/139 (38%)
Tlr6XP_030110224.1 leucine-rich repeat 47..64 CDD:275380 7/16 (44%)
PLN00113 50..>540 CDD:215061 146/687 (21%)
leucine-rich repeat 65..88 CDD:275378 9/25 (36%)
LRR_8 87..144 CDD:404697 20/61 (33%)
leucine-rich repeat 89..112 CDD:275378 7/24 (29%)
leucine-rich repeat 113..133 CDD:275378 6/22 (27%)
leucine-rich repeat 134..158 CDD:275378 9/25 (36%)
leucine-rich repeat 184..206 CDD:275380 7/30 (23%)
leucine-rich repeat 207..230 CDD:275380 5/22 (23%)
leucine-rich repeat 290..314 CDD:275380 4/23 (17%)
leucine-rich repeat 315..343 CDD:275380 6/45 (13%)
leucine-rich repeat 344..365 CDD:275380 4/20 (20%)
leucine-rich repeat 390..415 CDD:275380 5/40 (13%)
leucine-rich repeat 416..440 CDD:275380 12/69 (17%)
leucine-rich repeat 441..462 CDD:275380 5/42 (12%)
leucine-rich repeat 463..485 CDD:275380 9/27 (33%)
leucine-rich repeat 486..508 CDD:275380 8/48 (17%)
leucine-rich repeat 510..531 CDD:275380 7/21 (33%)
LRRCT 540..594 CDD:214507 18/66 (27%)
TIR 652..791 CDD:214587 53/140 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X221
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.920

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