DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and Tlr4

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_067272.1	Gene:	Tlr4 / 21898	MGIID:	96824	Length:	835	Species:	Mus musculus

Alignment Length:	1086	Identity:	252/1086 - (23%)
Similarity:	402/1086 - (37%)	Gaps:	294/1086 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 WLIPDGMVCPL----KSLQHLNASYNKIQDISNFYFSASLSSRKARVCGSTLQSLDLSANKMVSL 225
            ||:...::..|    .:...||.....:.:|:.......||.....:..|| :::|||.|.:..|
Mouse     5 WLLARTLIMALFFSCLTPGSLNPCIEVVPNITYQCMDQKLSKVPDDIPSST-KNIDLSFNPLKIL 68

  Fly   226 PTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLRVVDLSANRLTSLPPELFAETKQLQEIYLR 290
            .:...|....|..|::::..:..:.|:|:.||..|..:.|:.|.:.|..|..|:....|:.:...
Mouse    69 KSYSFSNFSELQWLDLSRCEIETIEDKAWHGLHHLSNLILTGNPIQSFSPGSFSGLTSLENLVAV 133

  Fly   291 NNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPL 355
            ...:..|.....|:|..|..|::|.|.::|..: .|.|..|..|:.:|||.|.|..:..:
Mouse   134 ETKLASLESFPIGQLITLKKLNVAHNFIHSCKL-PAYFSNLTNLVHVDLSYNYIQTITVN----- 192

  Fly   356 ASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQGLK-NLLVLSLDFNRISRM 419
             .||.|: |:..:            || :|.:|.|.|..|:.:..||:| :.|.|..:||..:.|
Mouse   193 -DLQFLR-ENPQV------------NL-SLDMSLNPIDFIQDQAFQGIKLHELTLRGNFNSSNIM 242

  Fly   420 DQRSLVNCSQ-LQDLHLNDNKLQAVPEALAHVQLLKTLDVGENMISQIENTSITQLESLYGLRMT 483
            .     .|.| |..||:             |..:|.......|:  :|...||  :|.|..:.:.
Mouse   243 K-----TCLQNLAGLHV-------------HRLILGEFKDERNL--EIFEPSI--MEGLCDVTID 285

  Fly   484 ENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNL 548
            |..||:..             :.|.:.:|                             |..|.|:
Mouse   286 EFRLTYTN-------------DFSDDIVK-----------------------------FHCLANV 308

  Fly   549 VWLNISGNRLEKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSI 613
            ..::::|..::..:  .:|...:|..:...| .||..:         .|.|..:  |..:|
Mouse   309 SAMSLAGVSIKYLE--DVPKHFKWQSLSIIR-CQLKQF---------PTLDLPF--LKSLT---- 355

  Fly   614 PNSVEVLYLNDNQISKIQPYTFFKK---PNLTRVDLVRNRL--------TTLEPNALRLSPIAED 667
                  |.:|...||       |||   |:|:.:||.||.|        :.|..|:||
Mouse   356 ------LTMNKGSIS-------FKKVALPSLSYLDLSRNALSFSGCCSYSDLGTNSLR------- 400

  Fly   668 REIPEFYIGHNAYECDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFL 732
                             :||  ...|.........|.|:::          .|:
Mouse   401 -----------------HLD--LSFNGAIIMSANFMGLEEL----------QHL----------- 425

  Fly   733 CKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSR-ASYEQTLPSHIPMDSTQL 796
                          |||                 .|....|.:.|. .|.|:.|...|...:|::
Mouse   426 --------------DFQ-----------------HSTLKRVTEFSAFLSLEKLLYLDISYTNTKI 459

  Fly   797 YLDGNNFRELQSHAFIGRKRLKVLHL--NHSRIEVLHNRTFYGLLELEVLQLQSNQLKALNGNEF 859
            ..||         .|:|...|..|.:  |..:...|.| .|.....|..|.|...||:.::...|
Mouse   460 DFDG---------IFLGLTSLNTLKMAGNSFKDNTLSN-VFANTTNLTFLDLSKCQLEQISWGVF 514

  Fly   860 QGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAI-TSFAVWNFLPSYLNELRLASNPWT 923
            ..|..||.|.:.||.:..:|:..:..||.|..|....|.| ||..:....|..|....|.:|...
Mouse   515 DTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRIETSKGILQHFPKSLAFFNLTNNSVA 579

  Fly   924 CSCEFIDKLRDYINRHEYVVDKLKMKCDVISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDN 988
            |.||....|:....:.:::|:..:|.|                     :.| |:.:.:|.|..:|
Mouse   580 CICEHQKFLQWVKEQKQFLVNVEQMTC---------------------ATP-VEMNTSLVLDFNN 622

  Fly   989 NFNYAEQAGGENASNATSTKMILNQPPKLDYIPILVAILTAFIFVMICISLVFIFRQEMRVWCHS 1053
            :..|             ..|.|::    :..:.::|....||:..                  |.
Mouse   623 STCY-------------MYKTIIS----VSVVSVIVVSTVAFLIY------------------HF 652

  Fly  1054 RFGVRLFYNAQKDVDKNEREKLFDAFVSYSSKDELFVNEELAPMLEMGEHRYKLCLHQRDFPVGG 1118
            .|.:.|....:|   .:..|.::||||.|||::|.:|..||...||.|..|:.||||.|||..|.
Mouse   653 YFHLILIAGCKK---YSRGESIYDAFVIYSSQNEDWVRNELVKNLEEGVPRFHLCLHYRDFIPGV 714

  Fly  1119 YLPETIVQ-AIDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQKELDP 1182
            .:...|:| ....||:.|:|||.:||:|.||.||::.|........|..:|.|||.:|.:..|..
Mouse   715 AIAANIIQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAQTWQFLSSRSGIIFIVLEKVEKSLLRQ 779

  Fly  1183 DLRLY--LKTNTYLQWGDK-----LFWQKLRFALPDVSSSQRSNVA 1221
            .:.||  |..||||:|.|.     :||::|:.||.|..:|.....|
Mouse   780 QVELYRLLSRNTYLEWEDNPLGRHIFWRRLKNALLDGKASNPEQTA 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	28/119 (24%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566	14/60 (23%)
		leucine-rich repeat	154..177	CDD:275380	3/15 (20%)
		leucine-rich repeat	178..201	CDD:275380	3/22 (14%)
		LRR	210..656	CDD:227223	103/458 (22%)
		leucine-rich repeat	212..235	CDD:275380	6/22 (27%)
		leucine-rich repeat	236..259	CDD:275380	6/22 (27%)
		leucine-rich repeat	260..283	CDD:275380	6/22 (27%)
		LRR_RI	276..558	CDD:238064	60/283 (21%)
		leucine-rich repeat	284..307	CDD:275380	4/22 (18%)
		leucine-rich repeat	308..333	CDD:275380	8/24 (33%)
		leucine-rich repeat	334..357	CDD:275380	6/22 (27%)
		leucine-rich repeat	358..381	CDD:275380	4/22 (18%)
		leucine-rich repeat	382..405	CDD:275380	9/23 (39%)
		leucine-rich repeat	406..429	CDD:275380	6/22 (27%)
		leucine-rich repeat	430..452	CDD:275380	4/21 (19%)
		leucine-rich repeat	453..500	CDD:275380	10/46 (22%)
		leucine-rich repeat	501..521	CDD:275380	2/19 (11%)
		leucine-rich repeat	525..547	CDD:275380	2/21 (10%)
		leucine-rich repeat	548..573	CDD:275380	2/24 (8%)
		leucine-rich repeat	604..640	CDD:275380	9/38 (24%)
		leucine-rich repeat	641..688	CDD:275380	11/54 (20%)
		leucine-rich repeat	689..816	CDD:275380	19/127 (15%)
		LRR_8	815..875	CDD:290566	18/61 (30%)
		leucine-rich repeat	817..864	CDD:275380	13/48 (27%)
		LRR_8	864..921	CDD:290566	17/57 (30%)
		leucine-rich repeat	865..888	CDD:275380	7/22 (32%)
		leucine-rich repeat	889..910	CDD:275380	6/21 (29%)
		TIR	1076..1211	CDD:214587	60/142 (42%)
Tlr4	NP_067272.1	LRR_8	53..113	CDD:290566	17/60 (28%)
		LRR 1	54..75		7/21 (33%)
		leucine-rich repeat	58..78	CDD:275380	6/19 (32%)
		LRR 2	78..99		4/20 (20%)
		leucine-rich repeat	79..102	CDD:275380	6/22 (27%)
		LRR 3	102..123		6/20 (30%)
		leucine-rich repeat	103..126	CDD:275380	6/22 (27%)
		LRR 4	126..147		2/20 (10%)
		leucine-rich repeat	127..150	CDD:275380	4/22 (18%)
		LRR_8	150..214	CDD:290566	23/84 (27%)
		LRR 5	150..171		6/21 (29%)
		leucine-rich repeat	151..175	CDD:275380	8/24 (33%)
		LRR 6	175..198		8/28 (29%)
		leucine-rich repeat	176..204	CDD:275380	10/46 (22%)
		LRR 7	204..224		7/20 (35%)
		leucine-rich repeat	205..226	CDD:275380	8/21 (38%)
		LRR 8	226..247		7/25 (28%)
		LRR 9	248..269		6/35 (17%)
		LRR 10	329..349		6/29 (21%)
		leucine-rich repeat	331..350	CDD:275380	5/28 (18%)
		LRR 11	350..370		9/38 (24%)
		leucine-rich repeat	351..372	CDD:275380	9/37 (24%)
		LRR_RI	<369..555	CDD:238064	56/273 (21%)
		LRR 12	372..392		6/19 (32%)
		leucine-rich repeat	373..398	CDD:275380	7/24 (29%)
		LRR 13	398..420		6/47 (13%)
		leucine-rich repeat	399..421	CDD:275380	7/47 (15%)
		LRR 14	421..442		7/72 (10%)
		leucine-rich repeat	422..446	CDD:275380	8/75 (11%)
		LRR 15	446..467		6/29 (21%)
		leucine-rich repeat	447..470	CDD:275380	7/31 (23%)
		LRR 16	470..490		5/20 (25%)
		leucine-rich repeat	471..495	CDD:275380	6/24 (25%)
		LRR_8	494..554	CDD:290566	18/59 (31%)
		LRR 17	495..516		6/20 (30%)
		leucine-rich repeat	496..519	CDD:275380	7/22 (32%)
		LRR 18	519..540		6/20 (30%)
		leucine-rich repeat	520..543	CDD:275380	7/22 (32%)
		LRR 19	543..564		6/20 (30%)
		Interaction with SCIMP. /evidence=ECO:0000269\|PubMed:28098138	670..835		63/156 (40%)
		TIR	672..813	CDD:214587	58/140 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6133
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.770