DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tollo and Tlr1

DIOPT Version :10

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_109607.1 Gene:Tlr1 / 21897 MGIID:1341295 Length:795 Species:Mus musculus


Alignment Length:971 Identity:215/971 - (22%)
Similarity:350/971 - (36%) Gaps:312/971 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   337 LDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQ 401
            ||||.|.||.|:......|:.|::|.:..|.:..|...:|...|.|..|.||.|.:.||......
Mouse    53 LDLSQNNISELQTSDILSLSKLRVLIMSYNRLQYLNISVFKFNTELEYLDLSHNELKVILCHPTV 117

  Fly   402 GLKNLLVLSLDFNRISRMD-QRSLVNCSQLQDLHLNDNKLQAVP-EALAHVQLLKTLDVGENMIS 464
            .||:   |.|.||....:. .:...|.||||.|.|:.:::|:.. :.:||:.:.|.|.|      
Mouse   118 SLKH---LDLSFNAFDALPICKEFGNMSQLQFLGLSGSRVQSSSVQLIAHLNISKVLLV------ 173

  Fly   465 QIENTSITQLESLYGLRMTENSLTHIR--------------RGVFDRMSSLQI-LNLSQNKLKSI 514
                     |...||.:....||.|:.              |.:.|...|..| |.||..|....
Mouse   174 ---------LGDAYGEKEDPESLRHVSTETLHIVFPSKREFRFLLDVSVSTTIGLELSNIKCVLE 229

  Fly   515 EAG---------SLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISGNRLEKFDYSHIPIGL 570
            :.|         .|.:|.:|..:.|  |.:::....|..:..:||              |.|:  
Mouse   230 DQGCSYFLRALSKLGKNLKLSNLTL--NNVETTWNSFINILQIVW--------------HTPV-- 276

  Fly   571 QWLDVRANRITQLGNYFEI-----ESELSLSTFDAS---------YNLLTEITASSIPNS-VEVL 620
                          .||.|     :.:|:...|:.|         :.::|::  .|.|.| :..:
Mouse   277 --------------KYFSISNVKLQGQLAFRMFNYSDTSLKALSIHQVVTDV--FSFPQSYIYSI 325

  Fly   621 YLNDNQISKIQPYTFF------------KKPNLTRVDLVRNRLTTLE----PNALRLSPIAEDRE 669
            :.|.|    ||.:|..            ..|.| .||...|.||.:.    .|.:||..::..:.
Mouse   326 FANMN----IQNFTMSGTHMVHMLCPSQVSPFL-HVDFTDNLLTDMVFKDCRNLVRLKTLSLQKN 385

  Fly   670 IPEFYIGHNAYECDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCK 734
                           .|..|:.:...|.....|..||.....|.|:.|.                
Mouse   386 ---------------QLKNLENIILTSAKMTSLQKLDISQNSLRYSDGG---------------- 419

  Fly   735 YASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTLPSHIPMDSTQLYLD 799
                                :.|          :||.::               :.::.:...|.
Mouse   420 --------------------IPC----------AWTQSL---------------LVLNLSSNMLT 439

  Fly   800 GNNFRELQSHAFIGRKRLKVLHLNHSRI-----EVLHNRTFYGLLELEVLQLQSNQLKALNG-NE 858
            |:.||.|.       .::|||.|:::||     :|.|      |..|:.|.:.||.|..|.| ..
Mouse   440 GSVFRCLP-------PKVKVLDLHNNRIMSIPKDVTH------LQALQELNVASNSLTDLPGCGA 491

  Fly   859 FQGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAITSFAVWNFLPSYLN--ELRLASNP 921
            |..                           |.:|.:|||:: |....:|..|..|  .|...:||
Mouse   492 FSS---------------------------LSVLVIDHNSV-SHPSEDFFQSCQNIRSLTAGNNP 528

  Fly   922 WTCSCEFIDKLRDYINRHEYVVDKLKMKCDVISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGL 986
            :.|:||    |||::....:|..      :|:.|........||.|....:|.....|   ||..
Mouse   529 FQCTCE----LRDFVKNIGWVAR------EVVEGWPDSYRCDYPESSRGTALRDFHMS---PLSC 580

  Fly   987 DNNFNYAEQAGGENASNATSTKMILNQPPKLDYIPILVAILTAFIFVMICISLVFI--------F 1043
            |.                                 :|:.:......:::.::..|:        :
Mouse   581 DT---------------------------------VLLTVTIGATMLVLAVTGAFLCLYFDLPWY 612

  Fly  1044 RQEMRVWCHSRFGVRLFYNAQKDVDKNEREKLFDAFVSYSSKDELFVNEELAPMLEMGEHRYKLC 1108
            .:.:..|..:|...|     ...:::.:|...|.||||||..|..:|..||.|.||..:  .::|
Mouse   613 VRMLCQWTQTRHRAR-----HIPLEELQRNLQFHAFVSYSGHDSAWVKNELLPNLEKDD--IQIC 670

  Fly  1109 LHQRDFPVGGYLPETIVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLG 1173
            ||:|:|..|..:.|.|:..|:.|.::|.|:|.:||:||||.:|...||.::..:....||:|:|.
Mouse   671 LHERNFVPGKSIVENIINFIEKSYKSIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLILILLA 735

  Fly  1174 EVPQKELDPD---LRLYLKTNTYLQWGDK-----LFWQKLRFALPDVSSSQRSNVAGQSCH 1226
            .:||..:..:   |:..:...|||:|..:     |||..||.::    :.:..|.|..:|:
Mouse   736 PIPQYSIPTNYHKLKTLMSRRTYLEWPTEKNKHGLFWANLRASI----NVKLVNQAEGTCY 792

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR 54..400 CDD:443914 22/62 (35%)
leucine-rich repeat 100..123 CDD:275380
leucine-rich repeat 124..144 CDD:275380
leucine-rich repeat 154..177 CDD:275380
leucine-rich repeat 178..201 CDD:275380
leucine-rich repeat 212..235 CDD:275380
leucine-rich repeat 236..259 CDD:275380
LRR 239..634 CDD:443914 80/337 (24%)
leucine-rich repeat 260..283 CDD:275380
leucine-rich repeat 284..307 CDD:275380
leucine-rich repeat 308..333 CDD:275380
leucine-rich repeat 334..357 CDD:275380 9/19 (47%)
leucine-rich repeat 358..381 CDD:275380 5/22 (23%)
leucine-rich repeat 382..405 CDD:275380 8/22 (36%)
leucine-rich repeat 406..429 CDD:275380 5/23 (22%)
leucine-rich repeat 430..452 CDD:275380 7/22 (32%)
leucine-rich repeat 453..500 CDD:275380 11/60 (18%)
leucine-rich repeat 501..521 CDD:275380 7/29 (24%)
leucine-rich repeat 525..547 CDD:275380 4/21 (19%)
leucine-rich repeat 548..573 CDD:275380 4/24 (17%)
leucine-rich repeat 604..640 CDD:275380 9/48 (19%)
LRR_8 616..>660 CDD:404697 14/60 (23%)
leucine-rich repeat 641..688 CDD:275380 10/50 (20%)
leucine-rich repeat 689..816 CDD:275380 16/126 (13%)
LRR <794..>920 CDD:443914 32/133 (24%)
leucine-rich repeat 817..864 CDD:275380 17/52 (33%)
leucine-rich repeat 865..888 CDD:275380 0/22 (0%)
leucine-rich repeat 889..910 CDD:275380 7/20 (35%)
TIR 1076..1211 CDD:214587 52/142 (37%)
Tlr1NP_109607.1 LRR <38..>156 CDD:443914 35/105 (33%)
leucine-rich repeat 50..73 CDD:275378 9/19 (47%)
PLN00113 52..>448 CDD:215061 108/534 (20%)
LRR 1 54..77 9/22 (41%)
leucine-rich repeat 74..97 CDD:275378 5/22 (23%)
LRR 2 78..101 5/22 (23%)
leucine-rich repeat 98..118 CDD:275378 7/19 (37%)
LRR 3 102..125 8/25 (32%)
leucine-rich repeat 119..143 CDD:275378 7/26 (27%)
LRR 4 126..150 8/23 (35%)
leucine-rich repeat 144..156 CDD:275378 4/11 (36%)
LRR 5 151..175 6/38 (16%)
LRR 6 176..199 5/22 (23%)
LRR 7 200..223 6/22 (27%)
LRR 8 224..250 4/25 (16%)
LRR 9 251..278 7/58 (12%)
LRR 10 279..308 5/28 (18%)
LRR 11 309..337 9/33 (27%)
Interaction with bacterial lipopeptide. /evidence=ECO:0000250 316..319 1/2 (50%)
LRR 12 338..361 4/23 (17%)
leucine-rich repeat 355..376 CDD:275380 6/20 (30%)
LRR <356..>529 CDD:443914 53/289 (18%)
LRR 13 362..388 5/40 (13%)
leucine-rich repeat 377..402 CDD:275380 4/39 (10%)
LRR 14 389..414 5/24 (21%)
leucine-rich repeat 403..427 CDD:275380 9/69 (13%)
LRR 15 415..437 5/82 (6%)
leucine-rich repeat 428..449 CDD:275380 5/42 (12%)
LRR 16 438..457 9/25 (36%)
leucine-rich repeat 450..472 CDD:275380 9/27 (33%)
LRR 17 458..478 7/25 (28%)
leucine-rich repeat 473..494 CDD:275380 8/20 (40%)
LRR 18 479..500 8/47 (17%)
leucine-rich repeat 495..518 CDD:275380 8/23 (35%)
LRR 19 501..524 8/23 (35%)
LRRCT 527..581 CDD:214507 18/66 (27%)
TIR 639..782 CDD:214587 52/148 (35%)
Blue background indicates that the domain is not in the aligned region.

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