DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tollo and dma-1

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_492253.1	Gene:	dma-1 / 187968	WormBaseID:	WBGene00011345	Length:	603	Species:	Caenorhabditis elegans

Alignment Length:	507	Identity:	126/507 - (24%)
Similarity:	213/507 - (42%)	Gaps:	119/507 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 LRVVDLSANRLTSLPPELFAETKQLQEIYLR-NNSINVLAPGIFGELAELLVLDLASNELNSQWI 323
            |..:.|:...|...||     :.::....|| |::||        ..|:|.||.|    :|.|..
Worm    55 LNQLPLTLRSLHIQPP-----SNRIGSNKLRWNDNIN--------RFAQLRVLRL----INCQIP 102

  Fly   324 NAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILS 388
            ..:..:.|..|.:|||.:|.|.......|..:..|::|.|..|:::.||.|:|..|..|.:|.||
Worm   103 AMSRSIRLPSLEVLDLHSNNIEHATMSNFGGMPKLRVLDLSSNHLNILPTGVFTYLRALRSLSLS 167

  Fly   389 RNRISVIEQRTLQGLKNLLVLSLD------------FNRISRMDQRSLVNCS------------- 428
            .|.||.:....|:||.:|.||.||            |..:|::|:..|.:|:
Worm   168 NNTISDLSTNLLRGLNSLRVLRLDRNPIPIEHINELFTDVSQLDELYLNHCNLSSIYSLALDRIP 232

  Fly   429 QLQDLHLNDNKLQAVP-EALAHVQLLKTLDVGENMISQIE-----NTSITQLESLYGLRMTENSL 487
            ||:.|.:..|.|:.|| :.|..:..|..||:..|.|.:|.     ||:|::|:      ::.|.|
Worm   233 QLRQLGIGGNNLKMVPTKELRSLPQLSVLDLSHNSIQEITACAFCNTNISKLD------LSHNLL 291

  Fly   488 THIRRGVFD----RMSSLQILNLSQNKLKSIEAGSL-QRNSQLQAIRLDGNQLKSIAGLFT-ELP 546
            ...:...|:    |...|:.|:||.|.:...::..| ....:|.:|.|.||.||:....:| .|.
Worm   292 GISKDSPFNEDAFRTMPLRHLDLSFNHMNDFDSKWLGWAQEELTSIALSGNFLKNFEESWTYTLK 356

  Fly   547 NLVWLNISGNRLEKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITAS 611
            :|:.|.::.|.: ||    ||:.|.            ..|:.:.| |::|..:.:|
Worm   357 SLIHLELAYNHI-KF----IPVQLP------------SRYYHLIS-LNISGNELTY--------- 394

  Fly   612 SIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEFYIG 676
             :|:::..|.                 ||:...|:..||..|...     :.:|....:.:.|:.
Worm   395 -LPDNINTLL-----------------PNVKTFDITANRFHTFSH-----TDLAFLNNVEQVYVD 436

  Fly   677 HNAYECDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKS 728
            .|.::|.|.:..||...|:......:::.|.:.|        :..||:|..|
Worm   437 GNPWDCSCAIQGLQVHMRDRYAMRHILNYDNVRC--------ATPSLVEGHS 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	5/20 (25%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223	112/433 (26%)
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380
		leucine-rich repeat	260..283	CDD:275380	5/22 (23%)
		LRR_RI	276..558	CDD:238064	89/319 (28%)
		leucine-rich repeat	284..307	CDD:275380	5/23 (22%)
		leucine-rich repeat	308..333	CDD:275380	7/24 (29%)
		leucine-rich repeat	334..357	CDD:275380	7/22 (32%)
		leucine-rich repeat	358..381	CDD:275380	9/22 (41%)
		leucine-rich repeat	382..405	CDD:275380	10/22 (45%)
		leucine-rich repeat	406..429	CDD:275380	10/47 (21%)
		leucine-rich repeat	430..452	CDD:275380	7/22 (32%)
		leucine-rich repeat	453..500	CDD:275380	14/55 (25%)
		leucine-rich repeat	501..521	CDD:275380	6/20 (30%)
		leucine-rich repeat	525..547	CDD:275380	9/22 (41%)
		leucine-rich repeat	548..573	CDD:275380	8/24 (33%)
		leucine-rich repeat	604..640	CDD:275380	2/35 (6%)
		leucine-rich repeat	641..688	CDD:275380	9/46 (20%)
		leucine-rich repeat	689..816	CDD:275380	9/40 (23%)
		LRR_8	815..875	CDD:290566
		leucine-rich repeat	817..864	CDD:275380
		LRR_8	864..921	CDD:290566
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
dma-1	NP_492253.1	LRR_8	90..147	CDD:338972	18/60 (30%)
		leucine-rich repeat	91..112	CDD:275380	7/24 (29%)
		leucine-rich repeat	113..136	CDD:275380	7/22 (32%)
		LRR	136..430	CDD:227223	88/349 (25%)
		leucine-rich repeat	137..160	CDD:275380	9/22 (41%)
		leucine-rich repeat	161..184	CDD:275380	10/22 (45%)
		leucine-rich repeat	185..209	CDD:275380	6/23 (26%)
		leucine-rich repeat	210..233	CDD:275380	3/22 (14%)
		leucine-rich repeat	234..257	CDD:275380	7/22 (32%)
		leucine-rich repeat	258..280	CDD:275380	7/21 (33%)
		leucine-rich repeat	281..307	CDD:275380	6/31 (19%)
		leucine-rich repeat	309..357	CDD:275380	15/47 (32%)
		leucine-rich repeat	382..405	CDD:275380	6/50 (12%)
		leucine-rich repeat	406..429	CDD:275380	5/27 (19%)
		TPKR_C2	438..>478	CDD:387596	10/47 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910