Protein Alignment Tollo and sym-1

DIOPT Version :10

• Sequence 1: NP_524757.1
• Gene: Tollo / 44497
• FlyBaseID: FBgn0029114
• Length: 1346
• Species: Drosophila melanogaster
• Sequence 2: NP_510426.1
• Gene: sym-1 / 181555
• WormBaseID: WBGene00006366
• Length: 680
• Species: Caenorhabditis elegans
• Alignment Length: 441
• Identity: 113/441 - (25%)
• Similarity: 201/441 - (45%)
• Gaps: 49/441 - (11%)

  Fly   129 IRTHNGDWSTMSLEMASNSFVEFRQLERLDLSLNNIWLIPDGMVCPLKSL--QHLNASYNKIQDI 191
            |:....|...|..::::.:.:|.|     :|:|.|..:|..|... .|:|  :.|..|.|:|:.|
 Worm    40 IKCSGHDGLRMVEKLSTTTTMEVR-----ELALENADIIEVGPKA-FKTLRIKKLILSNNRIEKI 98

  Fly   192 SNFYFSASLSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLADRAFEG 256
            .:..|:.         ..:.:|.|.||.|.:..:||:.|:.|..|..|::..|.:..:..:||..
 Worm    99 HDHAFTG---------LENVMQELSLSENNLKEVPTSALAGLRVLNILSLKCNKIENITTKAFVN 154

  Fly   257 LLSLRVVDLSANRLTSLPPELFAETK-QLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNS 320
            :.||..|:|..|::.|:..:.||..| .||.:.|.||.:                     .|..|
 Worm   155 MTSLIDVNLGCNQICSMAADTFANVKMSLQNLILDNNCM---------------------TEFPS 198

  Fly   321 QWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTL 385
            :.:.     .:..|:.|.:..|||:.:..:.|..|.||.:|.|..|.|.::.||...:..|||.|
 Worm   199 KAVR-----NMNNLIALHIKYNKINAIRQNDFVNLTSLSMLSLNGNNISEIKGGALQNTPNLHYL 258

  Fly   386 ILSRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAV-PEALAH 449
            .|:.|.:..::...|:..|.|.||.|.||..:.:.:........:|.|:|:.|::.|| |.|.|.
 Worm   259 YLNENNLQTLDNGVLEQFKQLQVLDLSFNNFTDITKEMFEGLESIQHLNLDSNRISAVAPGAFAG 323

  Fly   450 VQLLKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSI 514
            ..|| .|.:..|.::::...::.....|..:.::.|::..:....||.:.:|..|:|:.||:.|:
 Worm   324 TPLL-LLWLPNNCLTEVSQQTLKGAPFLRMVSLSNNNIREVHELSFDHLPNLHTLDLANNKIMSL 387

  Fly   515 EAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPN--LVWLNISGNRLEKFDY 563
            :..||.....| |:||..|.:..:...|..|.:  .:||....|.:.|.::
 Worm   388 QNKSLSGPENL-AVRLQENPVVCVKNGFHVLNSGEAIWLTNEANTICKGEW 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR	54..400	CDD:443914	69/273 (25%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380	3/14 (21%)
		leucine-rich repeat	154..177	CDD:275380	5/22 (23%)
		leucine-rich repeat	178..201	CDD:275380	7/24 (29%)
		leucine-rich repeat	212..235	CDD:275380	9/22 (41%)
		leucine-rich repeat	236..259	CDD:275380	5/22 (23%)
		LRR	239..634	CDD:443914	85/329 (26%)
		leucine-rich repeat	260..283	CDD:275380	8/23 (35%)
		leucine-rich repeat	284..307	CDD:275380	5/22 (23%)
		leucine-rich repeat	308..333	CDD:275380	2/24 (8%)
		leucine-rich repeat	334..357	CDD:275380	7/22 (32%)
		leucine-rich repeat	358..381	CDD:275380	7/22 (32%)
		leucine-rich repeat	382..405	CDD:275380	6/22 (27%)
		leucine-rich repeat	406..429	CDD:275380	6/22 (27%)
		leucine-rich repeat	430..452	CDD:275380	9/22 (41%)
		leucine-rich repeat	453..500	CDD:275380	7/46 (15%)
		leucine-rich repeat	501..521	CDD:275380	8/19 (42%)
		leucine-rich repeat	525..547	CDD:275380	7/21 (33%)
		leucine-rich repeat	548..573	CDD:275380	4/16 (25%)
		leucine-rich repeat	604..640	CDD:275380
		LRR_8	616..>660	CDD:404697
		leucine-rich repeat	641..688	CDD:275380
		leucine-rich repeat	689..816	CDD:275380
		LRR	<794..>920	CDD:443914
		leucine-rich repeat	817..864	CDD:275380
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
sym-1	NP_510426.1	leucine-rich repeat	62..81	CDD:275380	6/24 (25%)
		LRR	<84..408	CDD:443914	95/360 (26%)
		leucine-rich repeat	86..108	CDD:275380	6/30 (20%)
		leucine-rich repeat	110..133	CDD:275380	9/22 (41%)
		leucine-rich repeat	134..157	CDD:275380	5/22 (23%)
		leucine-rich repeat	158..182	CDD:275380	8/23 (35%)
		leucine-rich repeat	183..206	CDD:275380	7/48 (15%)
		leucine-rich repeat	207..230	CDD:275380	7/22 (32%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		leucine-rich repeat	255..278	CDD:275380	6/22 (27%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		leucine-rich repeat	303..323	CDD:275380	8/19 (42%)
		leucine-rich repeat	350..373	CDD:275380	4/22 (18%)
		leucine-rich repeat	374..394	CDD:275380	8/19 (42%)
		leucine-rich repeat	399..410	CDD:275378	4/10 (40%)