DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tollo and sym-1

DIOPT Version :9

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_510426.1 Gene:sym-1 / 181555 WormBaseID:WBGene00006366 Length:680 Species:Caenorhabditis elegans


Alignment Length:441 Identity:113/441 - (25%)
Similarity:201/441 - (45%) Gaps:49/441 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   129 IRTHNGDWSTMSLEMASNSFVEFRQLERLDLSLNNIWLIPDGMVCPLKSL--QHLNASYNKIQDI 191
            |:....|...|..::::.:.:|.|     :|:|.|..:|..|... .|:|  :.|..|.|:|:.|
 Worm    40 IKCSGHDGLRMVEKLSTTTTMEVR-----ELALENADIIEVGPKA-FKTLRIKKLILSNNRIEKI 98

  Fly   192 SNFYFSASLSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLADRAFEG 256
            .:..|:.         ..:.:|.|.||.|.:..:||:.|:.|..|..|::..|.:..:..:||..
 Worm    99 HDHAFTG---------LENVMQELSLSENNLKEVPTSALAGLRVLNILSLKCNKIENITTKAFVN 154

  Fly   257 LLSLRVVDLSANRLTSLPPELFAETK-QLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNS 320
            :.||..|:|..|::.|:..:.||..| .||.:.|.||.:                     .|..|
 Worm   155 MTSLIDVNLGCNQICSMAADTFANVKMSLQNLILDNNCM---------------------TEFPS 198

  Fly   321 QWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTL 385
            :.:.     .:..|:.|.:..|||:.:..:.|..|.||.:|.|..|.|.::.||...:..|||.|
 Worm   199 KAVR-----NMNNLIALHIKYNKINAIRQNDFVNLTSLSMLSLNGNNISEIKGGALQNTPNLHYL 258

  Fly   386 ILSRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAV-PEALAH 449
            .|:.|.:..::...|:..|.|.||.|.||..:.:.:........:|.|:|:.|::.|| |.|.|.
 Worm   259 YLNENNLQTLDNGVLEQFKQLQVLDLSFNNFTDITKEMFEGLESIQHLNLDSNRISAVAPGAFAG 323

  Fly   450 VQLLKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSI 514
            ..|| .|.:..|.::::...::.....|..:.::.|::..:....||.:.:|..|:|:.||:.|:
 Worm   324 TPLL-LLWLPNNCLTEVSQQTLKGAPFLRMVSLSNNNIREVHELSFDHLPNLHTLDLANNKIMSL 387

  Fly   515 EAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPN--LVWLNISGNRLEKFDY 563
            :..||.....| |:||..|.:..:...|..|.:  .:||....|.:.|.::
 Worm   388 QNKSLSGPENL-AVRLQENPVVCVKNGFHVLNSGEAIWLTNEANTICKGEW 437

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR_RI <85..281 CDD:238064 40/153 (26%)
leucine-rich repeat 100..123 CDD:275380
leucine-rich repeat 124..144 CDD:275380 3/14 (21%)
LRR_8 152..222 CDD:290566 19/71 (27%)
leucine-rich repeat 154..177 CDD:275380 5/22 (23%)
leucine-rich repeat 178..201 CDD:275380 7/24 (29%)
LRR 210..656 CDD:227223 95/358 (27%)
leucine-rich repeat 212..235 CDD:275380 9/22 (41%)
leucine-rich repeat 236..259 CDD:275380 5/22 (23%)
leucine-rich repeat 260..283 CDD:275380 8/23 (35%)
LRR_RI 276..558 CDD:238064 74/285 (26%)
leucine-rich repeat 284..307 CDD:275380 5/22 (23%)
leucine-rich repeat 308..333 CDD:275380 2/24 (8%)
leucine-rich repeat 334..357 CDD:275380 7/22 (32%)
leucine-rich repeat 358..381 CDD:275380 7/22 (32%)
leucine-rich repeat 382..405 CDD:275380 6/22 (27%)
leucine-rich repeat 406..429 CDD:275380 6/22 (27%)
leucine-rich repeat 430..452 CDD:275380 9/22 (41%)
leucine-rich repeat 453..500 CDD:275380 7/46 (15%)
leucine-rich repeat 501..521 CDD:275380 8/19 (42%)
leucine-rich repeat 525..547 CDD:275380 7/21 (33%)
leucine-rich repeat 548..573 CDD:275380 4/16 (25%)
leucine-rich repeat 604..640 CDD:275380
leucine-rich repeat 641..688 CDD:275380
leucine-rich repeat 689..816 CDD:275380
LRR_8 815..875 CDD:290566
leucine-rich repeat 817..864 CDD:275380
LRR_8 864..921 CDD:290566
leucine-rich repeat 865..888 CDD:275380
leucine-rich repeat 889..910 CDD:275380
TIR 1076..1211 CDD:214587
sym-1NP_510426.1 leucine-rich repeat 62..81 CDD:275380 6/24 (25%)
LRR_5 74..208 CDD:290045 39/169 (23%)
LRR_RI 81..384 CDD:238064 88/338 (26%)
leucine-rich repeat 86..108 CDD:275380 6/30 (20%)
leucine-rich repeat 110..133 CDD:275380 9/22 (41%)
leucine-rich repeat 134..157 CDD:275380 5/22 (23%)
leucine-rich repeat 158..182 CDD:275380 8/23 (35%)
LRR_8 182..241 CDD:290566 19/84 (23%)
leucine-rich repeat 183..206 CDD:275380 7/48 (15%)
leucine-rich repeat 207..230 CDD:275380 7/22 (32%)
leucine-rich repeat 231..254 CDD:275380 7/22 (32%)
LRR_8 253..313 CDD:290566 18/59 (31%)
leucine-rich repeat 255..278 CDD:275380 6/22 (27%)
leucine-rich repeat 279..302 CDD:275380 6/22 (27%)
LRR_8 302..384 CDD:290566 21/82 (26%)
leucine-rich repeat 303..323 CDD:275380 8/19 (42%)
leucine-rich repeat 350..373 CDD:275380 4/22 (18%)
leucine-rich repeat 374..394 CDD:275380 8/19 (42%)
leucine-rich repeat 399..410 CDD:275378 4/10 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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