DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tollo and let-4

DIOPT Version :9

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_510425.2 Gene:let-4 / 181554 WormBaseID:WBGene00002282 Length:773 Species:Caenorhabditis elegans


Alignment Length:528 Identity:134/528 - (25%)
Similarity:246/528 - (46%) Gaps:35/528 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly   188 IQDISNFYFSASLS---SRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFL 249
            :.|.||...|..|.   :.:|:|  ..:|||.::..::|.||....|.| .:..|::::|.:..:
 Worm    39 VLDCSNSSASGILQIIRTNQAQV--GLIQSLTMNQAELVELPPNFFSGL-FIRRLDLSQNKIKKI 100

  Fly   250 ADRAFEGLLS-LRVVDLSANRLTSLPPELFAETKQLQEIYLRNNSI-NVLAPGIFGELAELLVLD 312
            .|.||.|:.. |..|.|:.|.:..:|....|....|..:.|.|||| .:....||..|.:|..::
 Worm   101 DDAAFAGINPVLEEVVLNHNLIEKVPAAALAGLPNLLRLDLSNNSIVEIQEQEIFPNLNKLYDIN 165

  Fly   313 LASNELNSQWINAATFVGLKR-LMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIF 376
            |.||::.|  |:.:||..:|. :..::|..|.::.:.:...|.|..||.|.|..|.|:||....|
 Worm   166 LGSNKIFS--IHTSTFQNVKNSIQTINLGHNNMTAVPSSAIRGLKQLQSLHLHKNRIEQLDALNF 228

  Fly   377 ADLTNLHTLILSRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQ 441
            .:|..|:.|.|:.|:|..:.::....:.:|..|.|..|:|:::.........||:.|.|.:|::.
 Worm   229 LNLPVLNLLNLAGNQIHELNRQAFLNVPSLRYLYLSGNKITKLTAYQFQTFEQLEMLDLTNNEIG 293

  Fly   442 AVP-EALAHVQLLKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILN 505
            |:| .:|:.::.|:.|.:..|.||.|.:.:.|. .|:..|.::.|.|..:..|:...:.:||.::
 Worm   294 AIPANSLSGLKQLRQLYLAHNKISNISSNAFTN-SSIVVLVLSSNELKTLTAGIISGLPNLQQVS 357

  Fly   506 LSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIA-GLFTELPNLVWLNISGNRLEKFDYSHIPIG 569
            ...|::|:|...:....:.|..:.|..|||..|| ..|....||:.:::|.|:|.|..||.....
 Worm   358 FRDNQIKTINRNAFYDAASLVMLDLAKNQLTEIAPTTFLAQLNLLLVDLSENKLPKTPYSAFNSR 422

  Fly   570 LQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIPNSVEVLYLNDNQISKIQPYT 634
            :..:.::.|.:....|...::....:...| |.:::.....:..|..|.|..:.|:.||..:|..
 Worm   423 VGTVLLKENPLVCTENLHMLQQGTGVYVRD-SPDIICGRKPTPKPEPVLVPIVTDSLISTQRPAL 486

  Fly   635 FFKKPNLTRVDLVRNRLTT-------LEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKV 692
            .    .:.::.:.||..||       :...|.:...:.:.|.:|.   ||:.:..|      :..
 Worm   487 V----QIPKMQIHRNVHTTTGDQAPQIPSGAFQQIDLGKSRSLPR---GHSRFILD------KPS 538

  Fly   693 NRESRTQP 700
            .||...:|
 Worm   539 TREQSVEP 546

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR_RI <85..281 CDD:238064 27/96 (28%)
leucine-rich repeat 100..123 CDD:275380
leucine-rich repeat 124..144 CDD:275380
LRR_8 152..222 CDD:290566 10/36 (28%)
leucine-rich repeat 154..177 CDD:275380
leucine-rich repeat 178..201 CDD:275380 4/12 (33%)
LRR 210..656 CDD:227223 118/457 (26%)
leucine-rich repeat 212..235 CDD:275380 8/22 (36%)
leucine-rich repeat 236..259 CDD:275380 6/22 (27%)
leucine-rich repeat 260..283 CDD:275380 6/22 (27%)
LRR_RI 276..558 CDD:238064 80/285 (28%)
leucine-rich repeat 284..307 CDD:275380 9/23 (39%)
leucine-rich repeat 308..333 CDD:275380 8/24 (33%)
leucine-rich repeat 334..357 CDD:275380 4/22 (18%)
leucine-rich repeat 358..381 CDD:275380 10/22 (45%)
leucine-rich repeat 382..405 CDD:275380 5/22 (23%)
leucine-rich repeat 406..429 CDD:275380 5/22 (23%)
leucine-rich repeat 430..452 CDD:275380 7/22 (32%)
leucine-rich repeat 453..500 CDD:275380 12/46 (26%)
leucine-rich repeat 501..521 CDD:275380 5/19 (26%)
leucine-rich repeat 525..547 CDD:275380 8/22 (36%)
leucine-rich repeat 548..573 CDD:275380 7/24 (29%)
leucine-rich repeat 604..640 CDD:275380 7/35 (20%)
leucine-rich repeat 641..688 CDD:275380 10/53 (19%)
leucine-rich repeat 689..816 CDD:275380 3/12 (25%)
LRR_8 815..875 CDD:290566
leucine-rich repeat 817..864 CDD:275380
LRR_8 864..921 CDD:290566
leucine-rich repeat 865..888 CDD:275380
leucine-rich repeat 889..910 CDD:275380
TIR 1076..1211 CDD:214587
let-4NP_510425.2 leucine-rich repeat 66..86 CDD:275380 7/20 (35%)
LRR_RI <71..275 CDD:238064 59/206 (29%)
LRR_8 88..146 CDD:290566 16/57 (28%)
leucine-rich repeat 88..111 CDD:275380 6/22 (27%)
leucine-rich repeat 112..135 CDD:275380 6/22 (27%)
leucine-rich repeat 136..160 CDD:275380 9/23 (39%)
LRR_8 156..220 CDD:290566 19/65 (29%)
leucine-rich repeat 161..184 CDD:275380 8/24 (33%)
leucine-rich repeat 186..209 CDD:275380 4/22 (18%)
leucine-rich repeat 210..257 CDD:275380 15/46 (33%)
LRR_RI <250..411 CDD:238064 42/161 (26%)
LRR_8 256..316 CDD:290566 16/59 (27%)
leucine-rich repeat 258..281 CDD:275380 5/22 (23%)
leucine-rich repeat 282..305 CDD:275380 7/22 (32%)
leucine-rich repeat 306..328 CDD:275380 7/22 (32%)
LRR_8 327..387 CDD:290566 13/59 (22%)
leucine-rich repeat 329..350 CDD:275380 4/20 (20%)
leucine-rich repeat 353..400 CDD:275380 13/46 (28%)
leucine-rich repeat 356..376 CDD:275380 3/19 (16%)
leucine-rich repeat 401..419 CDD:275380 7/17 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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