DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tollo and Cd180

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_032559.2	Gene:	Cd180 / 17079	MGIID:	1194924	Length:	661	Species:	Mus musculus

Alignment Length:	742	Identity:	171/742 - (23%)
Similarity:	270/742 - (36%)	Gaps:	210/742 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 LSANRLTSLPPELFAETKQLQEIY-LRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAATF 328
            |::.|.|:...:...| |::.:.| ..|..:|.: ||......|  .|:.:.|.|.:  |...||
Mouse    15 LASCRATTSSDQKCIE-KEVNKTYNCENLGLNEI-PGTLPNSTE--CLEFSFNVLPT--IQNTTF 73

  Fly   329 VGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRIS 393
            ..|..|..|||:..:|..:.               ||.:..|         ..|.||:|:.|.:.
Mouse    74 SRLINLTFLDLTRCQIYWIH---------------EDTFQSQ---------HRLDTLVLTANPLI 114

  Fly   394 VIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAV--PEALAHVQLLKTL 456
            .:.:..|.|.|.|..|......||.:|...|.|...|:.|:|..|.:.::  |:... .:.||.|
Mouse   115 FMAETALSGPKALKHLFFIQTGISSIDFIPLHNQKTLESLYLGSNHISSIKLPKGFP-TEKLKVL 178

  Fly   457 DVGENMI---SQIENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNL--SQNKLKSIEA 516
            |...|.|   |:.:.:|:.|..:| .|.:..|.:..|..|.|| .:..|.||.  :||.|...:.
Mouse   179 DFQNNAIHYLSKEDMSSLQQATNL-SLNLNGNDIAGIELGAFD-SAVFQSLNFGGTQNLLVIFKG 241

  Fly   517 GSLQRNSQLQAIRL------DGNQL-----KSIAGLFTELPNL---VWLNISGNRLEKFDYSHIP 567
               .:||.:|::.|      |...:     :.:..:..|..||   .:.|||.|....|.
Mouse   242 ---LKNSTIQSLWLGTFEDMDDEDISPAVFEGLCEMSVESINLQKHYFFNISSNTFHCFS----- 298

  Fly   568 IGLQWLDVRANRITQLGNYFEIESELSLSTFDAS-YNLLTEITASSIPNSVEVLYLNDNQISKIQ 631
             |||.||:.|..:::|.:.....|.|......|: :..|.:|:||:.|:...:..
Mouse   299 -GLQELDLTATHLSELPSGLVGLSTLKKLVLSANKFENLCQISASNFPSLTHLSI---------- 352

  Fly   632 PYTFFKKPNLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYE-CDC------NLDWL 689
                  |.|..|::|....|..||             .:.|..:.|:..| .||      ||..|
Mouse   353 ------KGNTKRLELGTGCLENLE-------------NLRELDLSHDDIETSDCCNLQLRNLSHL 398

  Fly   690 QKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCK 754
            |.:|                  |:|   :..:||   |::.|
Mouse   399 QSLN------------------LSY---NEPLSL---KTEAF----------------------- 416

  Fly   755 MECPDRCSCYHDQSWTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFRELQSHAFIGRKRLKV 819
            .|||.                               ::...|.......::.|| .|.....|||
Mouse   417 KECPQ-------------------------------LELLDLAFTRLKVKDAQS-PFQNLHLLKV 449

  Fly   820 LHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKALN---GNEFQGLDNLQELYLQHNAIATIDTL 881
            |:|:||.:::...:.|.||..|:.|.||.|.....|   .|..|.|..|:.|.|....:::||..
Mouse   450 LNLSHSLLDISSEQLFDGLPALQHLNLQGNHFPKGNIQKTNSLQTLGRLEILVLSFCDLSSIDQH 514

  Fly   882 TFTHLYHLKILRLDHNAITSFAVWN------------------FLPSYL------NELRLASNPW 922
            .||.|..:..:.|.||.:||.::..                  .|||.|      ..:.|..||.
Mouse   515 AFTSLKMMNHVDLSHNRLTSSSIEALSHLKGIYLNLASNRISIILPSLLPILSQQRTINLRQNPL 579

  Fly   923 TCSCE---FIDKLRDYINRHEYVVDKL 946
            .|:|.   |::..::.:.:.|...|.|
Mouse   580 DCTCSNIYFLEWYKENMQKLEDTEDTL 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	3/15 (20%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223	102/413 (25%)
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380
		leucine-rich repeat	260..283	CDD:275380	4/17 (24%)
		LRR_RI	276..558	CDD:238064	77/303 (25%)
		leucine-rich repeat	284..307	CDD:275380	5/23 (22%)
		leucine-rich repeat	308..333	CDD:275380	7/24 (29%)
		leucine-rich repeat	334..357	CDD:275380	5/22 (23%)
		leucine-rich repeat	358..381	CDD:275380	3/22 (14%)
		leucine-rich repeat	382..405	CDD:275380	7/22 (32%)
		leucine-rich repeat	406..429	CDD:275380	7/22 (32%)
		leucine-rich repeat	430..452	CDD:275380	5/23 (22%)
		leucine-rich repeat	453..500	CDD:275380	16/49 (33%)
		leucine-rich repeat	501..521	CDD:275380	6/21 (29%)
		leucine-rich repeat	525..547	CDD:275380	4/32 (13%)
		leucine-rich repeat	548..573	CDD:275380	9/27 (33%)
		leucine-rich repeat	604..640	CDD:275380	6/35 (17%)
		leucine-rich repeat	641..688	CDD:275380	12/53 (23%)
		leucine-rich repeat	689..816	CDD:275380	16/126 (13%)
		LRR_8	815..875	CDD:290566	22/62 (35%)
		leucine-rich repeat	817..864	CDD:275380	19/49 (39%)
		LRR_8	864..921	CDD:290566	18/80 (23%)
		leucine-rich repeat	865..888	CDD:275380	8/22 (36%)
		leucine-rich repeat	889..910	CDD:275380	6/38 (16%)
		TIR	1076..1211	CDD:214587
Cd180	NP_032559.2	leucine-rich repeat	38..57	CDD:275380	5/21 (24%)
		LRR 1	54..75		7/24 (29%)
		leucine-rich repeat	58..78	CDD:275380	7/21 (33%)
		LRR 2	78..99		7/35 (20%)
		leucine-rich repeat	79..102	CDD:275380	8/46 (17%)
		LRR 3	102..123		6/20 (30%)
		leucine-rich repeat	103..126	CDD:275380	7/22 (32%)
		LRR 4	126..147		6/20 (30%)
		leucine-rich repeat	127..150	CDD:275380	7/22 (32%)
		LRR 5	150..171		5/20 (25%)
		leucine-rich repeat	151..174	CDD:275380	5/23 (22%)
		LRR 6	174..195		7/20 (35%)
		leucine-rich repeat	175..201	CDD:275380	9/25 (36%)
		LRR 7	201..221		7/21 (33%)
		leucine-rich repeat	224..275	CDD:275380	11/53 (21%)
		LRR 8	275..296		7/20 (35%)
		leucine-rich repeat	276..299	CDD:275380	8/28 (29%)
		LRR 9	299..321		7/21 (33%)
		leucine-rich repeat	300..322	CDD:275380	6/21 (29%)
		LRR_8	321..382	CDD:290566	17/89 (19%)
		LRR 10	322..343		5/20 (25%)
		leucine-rich repeat	323..346	CDD:275380	6/22 (27%)
		LRR_RI	345..>541	CDD:238064	63/303 (21%)
		LRR 11	346..366		4/35 (11%)
		leucine-rich repeat	347..371	CDD:275380	7/52 (13%)
		LRR_8	371..432	CDD:290566	20/138 (14%)
		LRR 12	371..391		5/19 (26%)
		leucine-rich repeat	372..397	CDD:275380	7/24 (29%)
		LRR 13	397..418		9/67 (13%)
		leucine-rich repeat	398..421	CDD:275380	11/69 (16%)
		LRR_8	420..481	CDD:290566	20/92 (22%)
		LRR 14	421..442		3/52 (6%)
		leucine-rich repeat	422..446	CDD:275380	4/24 (17%)
		LRR 15	446..466		7/19 (37%)
		leucine-rich repeat	447..470	CDD:275380	10/22 (45%)
		LRR 16	470..493		7/22 (32%)
		leucine-rich repeat	471..497	CDD:275380	9/25 (36%)
		LRR_8	497..555	CDD:290566	13/57 (23%)
		LRR 17	497..518		6/20 (30%)
		leucine-rich repeat	498..521	CDD:275380	8/22 (36%)
		LRR 18	521..544		5/22 (23%)
		leucine-rich repeat	522..545	CDD:275380	5/22 (23%)
		LRR 19	546..566		4/19 (21%)
		LRRCT	577..626	CDD:214507	8/30 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820