DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and Tlr7

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_001277687.1	Gene:	Tlr7 / 170743	MGIID:	2176882	Length:	1053	Species:	Mus musculus

Alignment Length:	1224	Identity:	272/1224 - (22%)
Similarity:	461/1224 - (37%)	Gaps:	336/1224 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 PQNTVRLRLECNDALFFQSSLSPDSFRSLVELRDLTIEYCKLGNLTDGSFRGLQELRNLTIRTHN 133
            |.||..|.|..|..    .|:||||||.|..|.::.:. |....:..||               .
Mouse    67 PTNTTNLTLTINHI----PSISPDSFRRLNHLEEIDLR-CNCVPVLLGS---------------K 111

  Fly   134 GDWSTMSLEMASNSFVEFRQLERLDLSLNNIWLIPDGMVCPLKSLQHLNASYNKIQDISNFYFSA 198
            .:..|..|::...||.....|:.|.|..|.:..||                    ||:.
Mouse   112 ANVCTKRLQIRPGSFSGLSDLKALYLDGNQLLEIP--------------------QDLP------ 150

  Fly   199 SLSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKN-------SMSFLADR-AFE 255
                       |:|..|.|.||.:.|:....|:.|..:..|.:.:|       ::|:..:: ||.
Mouse   151 -----------SSLHLLSLEANNIFSITKENLTELVNIETLYLGQNCYYRNPCNVSYSIEKDAFL 204

  Fly   256 GLLSLRVVDLSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASN---- 316
            .:.:|:|:.|..|.:|::|..|   ...|.|:||.||.|..:....|..|.||.||||:.|
Mouse   205 VMRNLKVLSLKDNNVTAVPTTL---PPNLLELYLYNNIIKKIQENDFNNLNELQVLDLSGNCPRC 266

  Fly   317 ----------ELNSQWINAATFVGLKRLMMLDLSANKISRLEAH--IFRPLASLQILKLEDNYID 369
                      |.||.                         |:.|  .|..|..|::|:|..|.:.
Mouse   267 YNVPYPCTPCENNSP-------------------------LQIHDNAFNSLTELKVLRLHSNSLQ 306

  Fly   370 QLPGGIFADLTNLHTLILSRNRIS--VIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQD 432
            .:|...|.::.||..|.||:|.::  :.|.:.|..|.||:.|...||             .:||.
Mouse   307 HVPPTWFKNMRNLQELDLSQNYLAREIEEAKFLHFLPNLVELDFSFN-------------YELQV 358

  Fly   433 LHLNDNKLQAVPEALAHVQLLKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHIR---RGV 494
            .|.:    ..:|.:|:.::.||.|.|...:..:::|:|::.|..|..|.:.:.....|:   ..:
Mouse   359 YHAS----ITLPHSLSSLENLKILRVKGYVFKELKNSSLSVLHKLPRLEVLDLGTNFIKIADLNI 419

  Fly   495 FDRMSSLQILNLSQNKL----KSIEAG-------SLQRNSQ--LQAI---RLDGNQLKSIAGLFT 543
            |....:|::::||.||:    :|.|.|       |:.|:..  |:|:   |.| ...:|......
Mouse   420 FKHFENLKLIDLSVNKISPSEESREVGFCPNAQTSVDRHGPQVLEALHYFRYD-EYARSCRFKNK 483

  Fly   544 ELPNLVWLN-----------ISGNR---LEKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELS 594
            |.|:.:.||           :|.|.   ::..|:.|:.. |:.|::..|.|.|..|..|:.....
Mouse   484 EPPSFLPLNADCHIYGQTLDLSRNNIFFIKPSDFQHLSF-LKCLNLSGNTIGQTLNGSELWPLRE 547

  Fly   595 LSTFDASYNLLTEI--TASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLTTLEPN 657
            |...|.|.|.|..:  ||.....|:|||.|:.|.       .:|:...:|.:.....:|..|:
Mouse   548 LRYLDFSNNRLDLLYSTAFEELQSLEVLDLSSNS-------HYFQAEGITHMLNFTKKLRLLD-- 603

  Fly   658 ALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVS 722
                ..:..|.:|                         |.:..:.|:.|.:  |:...|| :|:.
Mouse   604 ----KLMMNDNDI-------------------------STSASRTMESDSL--RILEFRG-NHLD 636

  Fly   723 LIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTLPS 787
            ::....|:....:..:.|.|                             .|:|.||.|. .:||.
Mouse   637 VLWRAGDNRYLDFFKNLFNL-----------------------------EVLDISRNSL-NSLPP 671

  Fly   788 HI----PMDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQS 848
            .:    |.:...|.|..|..:..    |..|.:|    |.|                ||:|.|..
Mouse   672 EVFEGMPPNLKNLSLAKNGLKSF----FWDRLQL----LKH----------------LEILDLSH 712

  Fly   849 NQLKALNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAITSFAVWNFLPSYLN 913
            |||..:.........:|..|.|:||.|..:..........|:.|.:..|.|......:|..:.||
Mouse   713 NQLTKVPERLANCSKSLTTLILKHNQIRQLTKYFLEDALQLRYLDISSNKIQVIQKTSFPENVLN 777

  Fly   914 ELR---LASNPWTCSCE---FIDKLRDYINRHEYVVDKLKMKCDVISGNSTQQMVIYPGS--GEP 970
            .|.   |..|.:.|:|:   |:    .::|..:..:..|          :|....:.||:  |:.
Mouse   778 NLEMLVLHHNRFLCNCDAVWFV----WWVNHTDVTIPYL----------ATDVTCVGPGAHKGQS 828

  Fly   971 A-SLPVVQCSQTLPLGLDNNFNYAEQAGGENASNATSTKMILNQPPKLDYIPILVAILTAFIFVM 1034
            . ||.:..|...|                        |.:||........:.::|.:.|:.:|..
Mouse   829 VISLDLYTCELDL------------------------TNLILFSVSISSVLFLMVVMTTSHLFFW 869

  Fly  1035 ICISLVFIFRQEMRVWCHSRFGVRLFYNAQKDVDKNEREKLFDAFVSYSSKD----ELFVNEELA 1095
            ....:.:.::.:::.:.|.:                ..|..:|||:.|.:|:    |..:.|.:|
Mouse   870 DMWYIYYFWKAKIKGYQHLQ----------------SMESCYDAFIVYDTKNSAVTEWVLQELVA 918

  Fly  1096 PMLEMGEHRYKLCLHQRDFPVGGYLPETIVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVL 1160
            .:.:..|..:.|||.:||:..|..:.|.:.|:|..|::|:.|:::.:.|:|..:..|..:||.:|
Mouse   919 KLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAKTESFKMAFYLSHQRLL 983

  Fly  1161 RDRRRRLIVIVLGEVPQKELDPDLRLYLKTNTYLQW-----GDKLFWQKLRFAL 1209
            .::...:|:|.|.:..||.....||..|..::.|:|     ....|||.|:.||
Mouse   984 DEKVDVIILIFLEKPLQKSKFLQLRKRLCRSSVLEWPANPQAHPYFWQCLKNAL 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	45/203 (22%)
		leucine-rich repeat	100..123	CDD:275380	4/22 (18%)
		leucine-rich repeat	124..144	CDD:275380	2/19 (11%)
		LRR_8	152..222	CDD:290566	14/69 (20%)
		leucine-rich repeat	154..177	CDD:275380	6/22 (27%)
		leucine-rich repeat	178..201	CDD:275380	2/22 (9%)
		LRR	210..656	CDD:227223	127/506 (25%)
		leucine-rich repeat	212..235	CDD:275380	8/22 (36%)
		leucine-rich repeat	236..259	CDD:275380	5/30 (17%)
		leucine-rich repeat	260..283	CDD:275380	7/22 (32%)
		LRR_RI	276..558	CDD:238064	81/332 (24%)
		leucine-rich repeat	284..307	CDD:275380	9/22 (41%)
		leucine-rich repeat	308..333	CDD:275380	9/38 (24%)
		leucine-rich repeat	334..357	CDD:275380	4/24 (17%)
		leucine-rich repeat	358..381	CDD:275380	6/22 (27%)
		leucine-rich repeat	382..405	CDD:275380	8/24 (33%)
		leucine-rich repeat	406..429	CDD:275380	4/22 (18%)
		leucine-rich repeat	430..452	CDD:275380	5/21 (24%)
		leucine-rich repeat	453..500	CDD:275380	11/49 (22%)
		leucine-rich repeat	501..521	CDD:275380	9/30 (30%)
		leucine-rich repeat	525..547	CDD:275380	6/24 (25%)
		leucine-rich repeat	548..573	CDD:275380	7/38 (18%)
		leucine-rich repeat	604..640	CDD:275380	10/37 (27%)
		leucine-rich repeat	641..688	CDD:275380	5/46 (11%)
		leucine-rich repeat	689..816	CDD:275380	23/130 (18%)
		LRR_8	815..875	CDD:290566	15/59 (25%)
		leucine-rich repeat	817..864	CDD:275380	10/46 (22%)
		LRR_8	864..921	CDD:290566	15/59 (25%)
		leucine-rich repeat	865..888	CDD:275380	6/22 (27%)
		leucine-rich repeat	889..910	CDD:275380	5/20 (25%)
		TIR	1076..1211	CDD:214587	43/143 (30%)
Tlr7	NP_001277687.1	PRK15370	<35..>246	CDD:185268	58/238 (24%)
		leucine-rich repeat	51..72	CDD:275380	3/4 (75%)
		leucine-rich repeat	73..93	CDD:275380	11/23 (48%)
		leucine-rich repeat	94..131	CDD:275380	8/52 (15%)
		leucine-rich repeat	132..155	CDD:275380	10/59 (17%)
		PLN00113	177..>789	CDD:215061	169/753 (22%)
		leucine-rich repeat	177..208	CDD:275380	5/30 (17%)
		leucine-rich repeat	209..229	CDD:275380	7/22 (32%)
		leucine-rich repeat	230..253	CDD:275380	9/22 (41%)
		leucine-rich repeat	254..294	CDD:275380	13/64 (20%)
		leucine-rich repeat	295..318	CDD:275380	6/22 (27%)
		leucine-rich repeat	319..344	CDD:275380	8/24 (33%)
		leucine-rich repeat	345..401	CDD:275380	17/72 (24%)
		leucine-rich repeat	402..425	CDD:275380	3/22 (14%)
		leucine-rich repeat	500..522	CDD:275380	4/21 (19%)
		leucine-rich repeat	523..547	CDD:275380	7/23 (30%)
		leucine-rich repeat	548..571	CDD:275380	7/22 (32%)
		leucine-rich repeat	572..601	CDD:275380	8/35 (23%)
		leucine-rich repeat	602..624	CDD:275380	5/52 (10%)
		leucine-rich repeat	625..655	CDD:275380	5/32 (16%)
		leucine-rich repeat	656..680	CDD:275380	9/53 (17%)
		leucine-rich repeat	681..704	CDD:275380	7/30 (23%)
		leucine-rich repeat	705..728	CDD:275380	7/22 (32%)
		leucine-rich repeat	753..778	CDD:275380	6/24 (25%)
		PCC	757..>841	CDD:188093	20/97 (21%)
		TIR	894..1039	CDD:214587	43/144 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.780