DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and CHADL

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	XP_011528235.1	Gene:	CHADL / 150356	HGNCID:	25165	Length:	830	Species:	Homo sapiens

Alignment Length:	822	Identity:	181/822 - (22%)
Similarity:	286/822 - (34%)	Gaps:	230/822 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 NASYNKIQDISNFYFSASLSSRKARVC---------------GSTLQSLDLSANKMVSLPTAMLS 231
            |||::.:..:.........|.:....|               |...|.|||..|.:..:|.|...
Human    87 NASHSALSQLPGLRAVEGGSCQAGTACPCAAPPGWTSSSRRHGGLTQRLDLQGNLLKVIPAAAFQ 151

  Fly   232 ALGRLTHLNMAKNSMSFLADRAFEGLLSLRVVDLSANRLTSLPPELFAETKQLQEIYLRNNSINV 296
            .:..||||::....:..:|:.||.||..|.:::|::|.|..||.|.......|:.:.|..|::..
Human   152 GVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNALEE 216

  Fly   297 LAPGIFGELAELLVLDLASNELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQIL 361
            |.||.||.|..|..|:||.|.|  .::.|..|.||.|:..|.||.|.:|.|.......|.:|:.|
Human   217 LRPGTFGALGALATLNLAHNAL--VYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRL 279

  Fly   362 KLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQR---TLQGLKNLLVLSLDFNRISRMDQRS 423
            .|..|.:..|||.:.:....|..|.|..|.::...:.   .|.||:.||   ||...:..:..|:
Human   280 SLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELL---LDGGALQALGPRA 341

  Fly   424 LVNCSQLQDLHLNDNKLQAVPEALAHVQLLKTLDVGENMISQIENTSITQLESLYGLRMTENSLT 488
            ..:|.:|..|.|..|:|..:|......||.:                         ||:..|.|
Human   342 FAHCPRLHTLDLRGNQLDTLPPLQGPGQLRR-------------------------LRLQGNPL- 380

  Fly   489 HIRRGVFDRMSSLQILN-LSQNKLKSIEAGSLQRNSQLQAIRLDGNQ---LKSIAGLFTELPNLV 549
                  :....:..:|. |::.:::|  .|:.|...:|:...||..:   |:.......|...|.
Human   381 ------WCGCQARPLLEWLARARVRS--DGACQGPRRLRGEALDALRPWDLRCPGDAAQEEEELE 437

  Fly   550 WLNISGNR---------------------------------LEKFDYSHIPIGL----QWLDVRA 577
            ...::|.|                                 .|......:|.|.    |.||:|.
Human   438 ERAVAGPRAPPRGPPRGPGEERAVAPCPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRR 502

  Fly   578 NRITQ--------LGNYFEIESELSLSTFDASYNLLTEITASSIP--NSVEVLYLNDNQISKIQP 632
            |....        ||:         |.:....:..:.|:.|.::.  ..:..|||:|||::.:..
Human   503 NHFPSVPRAAFPGLGH---------LVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSA 558

  Fly   633 YTFFKKPNLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNRESR 697
            ......|.|..:.|.|||...:...|||..|     .:...::..||.:
Human   559 AALEGAPRLGYLYLERNRFLQVPGAALRALP-----SLFSLHLQDNAVD---------------- 602

  Fly   698 TQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCS 762
                         |||                                            |....
Human   603 -------------RLA--------------------------------------------PGDLG 610

  Fly   763 CYHDQSWTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRI 827
            ......|                          :||.||...|:...|....:.|:.|||:.:::
Human   611 RTRALRW--------------------------VYLSGNRITEVSLGALGPARELEKLHLDRNQL 649

  Fly   828 EVLHNRTFYGLLELEVLQLQSNQLKALNGNEFQGLD-NLQELYLQHNAIATIDTLTFTHL-YHLK 890
            ..:......||..|..|||..|.|:||....||.:. :||.|:|..:.:..|....|:.| ..|:
Human   650 REVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQ 714

  Fly   891 ILRLDHNAITSFAVWNFLPSYLNELR---LASNPWTCSCEFI 929
            .|.|..|.:.:...   ||| |::|.   |:|||:.|.|:.:
Human   715 SLHLQKNQLRALPA---LPS-LSQLELIDLSSNPFHCDCQLL 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	29/113 (26%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566	11/54 (20%)
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380	3/18 (17%)
		LRR	210..656	CDD:227223	120/499 (24%)
		leucine-rich repeat	212..235	CDD:275380	7/22 (32%)
		leucine-rich repeat	236..259	CDD:275380	9/22 (41%)
		leucine-rich repeat	260..283	CDD:275380	7/22 (32%)
		LRR_RI	276..558	CDD:238064	73/321 (23%)
		leucine-rich repeat	284..307	CDD:275380	9/22 (41%)
		leucine-rich repeat	308..333	CDD:275380	10/24 (42%)
		leucine-rich repeat	334..357	CDD:275380	7/22 (32%)
		leucine-rich repeat	358..381	CDD:275380	7/22 (32%)
		leucine-rich repeat	382..405	CDD:275380	7/25 (28%)
		leucine-rich repeat	406..429	CDD:275380	6/22 (27%)
		leucine-rich repeat	430..452	CDD:275380	6/21 (29%)
		leucine-rich repeat	453..500	CDD:275380	4/46 (9%)
		leucine-rich repeat	501..521	CDD:275380	4/20 (20%)
		leucine-rich repeat	525..547	CDD:275380	5/24 (21%)
		leucine-rich repeat	548..573	CDD:275380	7/61 (11%)
		leucine-rich repeat	604..640	CDD:275380	8/37 (22%)
		leucine-rich repeat	641..688	CDD:275380	11/46 (24%)
		leucine-rich repeat	689..816	CDD:275380	11/126 (9%)
		LRR_8	815..875	CDD:290566	20/60 (33%)
		leucine-rich repeat	817..864	CDD:275380	16/47 (34%)
		LRR_8	864..921	CDD:290566	18/60 (30%)
		leucine-rich repeat	865..888	CDD:275380	7/23 (30%)
		leucine-rich repeat	889..910	CDD:275380	5/20 (25%)
		TIR	1076..1211	CDD:214587
CHADL	XP_011528235.1	leucine-rich repeat	132..155	CDD:275380	7/22 (32%)
		LRR_RI	<133..358	CDD:238064	74/229 (32%)
		LRR_8	133..214	CDD:290566	26/80 (33%)
		leucine-rich repeat	156..179	CDD:275380	9/22 (41%)
		leucine-rich repeat	180..203	CDD:275380	7/22 (32%)
		leucine-rich repeat	204..227	CDD:275380	9/22 (41%)
		LRR_8	228..286	CDD:290566	22/59 (37%)
		leucine-rich repeat	228..251	CDD:275380	10/24 (42%)
		leucine-rich repeat	252..275	CDD:275380	7/22 (32%)
		leucine-rich repeat	276..299	CDD:275380	7/22 (32%)
		leucine-rich repeat	300..323	CDD:275380	5/22 (23%)
		LRR_8	322..380	CDD:290566	19/85 (22%)
		leucine-rich repeat	324..347	CDD:275380	7/25 (28%)
		LRR_4	346..>380	CDD:289563	11/58 (19%)
		LRRNT	463..497	CDD:214470	3/33 (9%)
		leucine-rich repeat	478..494	CDD:275380	3/15 (20%)
		LRR_RI	492..671	CDD:238064	49/291 (17%)
		leucine-rich repeat	495..518	CDD:275380	6/22 (27%)
		LRR_8	518..577	CDD:290566	14/67 (21%)
		leucine-rich repeat	519..542	CDD:275380	3/22 (14%)
		leucine-rich repeat	543..566	CDD:275380	6/22 (27%)
		LRR_8	565..625	CDD:290566	21/163 (13%)
		leucine-rich repeat	567..590	CDD:275380	9/27 (33%)
		leucine-rich repeat	591..614	CDD:275380	6/95 (6%)
		leucine-rich repeat	615..638	CDD:275380	7/48 (15%)
		LRR_8	637..698	CDD:290566	20/60 (33%)
		leucine-rich repeat	639..662	CDD:275380	6/22 (27%)
		leucine-rich repeat	663..687	CDD:275380	10/23 (43%)
		LRR_8	686..745	CDD:290566	19/62 (31%)
		leucine-rich repeat	688..712	CDD:275380	7/23 (30%)
		LRR_4	711..>744	CDD:289563	11/36 (31%)
		LRRCT	743..791	CDD:214507	4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	171	1.000	Inparanoid score	I4103
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.960