Protein Alignment Tollo and LRFN5

DIOPT Version :10

• Sequence 1: NP_524757.1
• Gene: Tollo / 44497
• FlyBaseID: FBgn0029114
• Length: 1346
• Species: Drosophila melanogaster
• Sequence 2: NP_689660.2
• Gene: LRFN5 / 145581
• HGNCID: 20360
• Length: 719
• Species: Homo sapiens
• Alignment Length: 238
• Identity: 67/238 - (28%)
• Similarity: 111/238 - (46%)
• Gaps: 30/238 - (12%)

  Fly   361 LKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLV 425
            |:|.||::..:....||::|:|..|.||||.||.|.......|:||..|.|:.||::::......
Human    56 LRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFS 120

  Fly   426 NCSQLQDLHLNDNKLQAVPE-ALAHVQLLKTLDVGENMISQIENTSITQLESLYGLRMTENSLTH 489
            ..|.|..|.||:|:|..:.. |...|..|:.||:..|.:..|...::.::.||:.|.:..|.:.:
Human   121 GLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDN 185

  Fly   490 IRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWLNIS 554
            |.:|.|..:..:..|:::.|||:.:....|.:.:|:.|          .:|:.:  |:...|:..
Human   186 IPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLA----------TSGIIS--PSTFALSFG 238

  Fly   555 GNRLEKFDYSHIPIGLQWLDVRANRITQL----------GNYF 587
            ||.|      |....|.||. |.:|...|          |.||
Human   239 GNPL------HCNCELLWLR-RLSREDDLETCASPPLLTGRYF 274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR	54..400	CDD:443914	16/38 (42%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380
		LRR	239..634	CDD:443914	67/238 (28%)
		leucine-rich repeat	260..283	CDD:275380
		leucine-rich repeat	284..307	CDD:275380
		leucine-rich repeat	308..333	CDD:275380
		leucine-rich repeat	334..357	CDD:275380
		leucine-rich repeat	358..381	CDD:275380	6/19 (32%)
		leucine-rich repeat	382..405	CDD:275380	10/22 (45%)
		leucine-rich repeat	406..429	CDD:275380	5/22 (23%)
		leucine-rich repeat	430..452	CDD:275380	8/22 (36%)
		leucine-rich repeat	453..500	CDD:275380	12/46 (26%)
		leucine-rich repeat	501..521	CDD:275380	5/19 (26%)
		leucine-rich repeat	525..547	CDD:275380	2/21 (10%)
		leucine-rich repeat	548..573	CDD:275380	6/24 (25%)
		leucine-rich repeat	604..640	CDD:275380
		LRR_8	616..>660	CDD:404697
		leucine-rich repeat	641..688	CDD:275380
		leucine-rich repeat	689..816	CDD:275380
		LRR	<794..>920	CDD:443914
		leucine-rich repeat	817..864	CDD:275380
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
LRFN5	NP_689660.2	LRR 1	52..73		5/16 (31%)
		leucine-rich repeat	53..76	CDD:275380	6/19 (32%)
		LRR	<69..>211	CDD:443914	44/141 (31%)
		LRR 2	76..97		9/20 (45%)
		leucine-rich repeat	77..100	CDD:275380	10/22 (45%)
		LRR 3	100..121		6/20 (30%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		LRR 4	124..145		7/20 (35%)
		leucine-rich repeat	125..148	CDD:275380	8/22 (36%)
		LRR 5	148..169		5/20 (25%)
		leucine-rich repeat	149..172	CDD:275380	5/22 (23%)
		LRR 6	172..193		7/20 (35%)
		leucine-rich repeat	173..196	CDD:275380	6/22 (27%)
		LRR 7	196..217		5/20 (25%)
		leucine-rich repeat	197..215	CDD:275380	4/17 (24%)
		LRRCT	240..>272	CDD:214507	9/38 (24%)
		IgI_SALM5_like	287..374	CDD:409421
		Ig strand A	287..290	CDD:409421
		Ig strand A'	294..297	CDD:409421
		Ig strand B	303..311	CDD:409421
		Ig strand C	317..322	CDD:409421
		Ig strand C'	325..327	CDD:409421
		Ig strand D	333..337	CDD:409421
		Ig strand E	340..344	CDD:409421
		Ig strand F	354..361	CDD:409421
		Ig strand G	364..374	CDD:409421
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	385..414
		FN3	421..494	CDD:473895
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	615..694