DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and Tlr3

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_001344245.1	Gene:	Tlr3 / 142980	MGIID:	2156367	Length:	905	Species:	Mus musculus

Alignment Length:	1103	Identity:	265/1103 - (24%)
Similarity:	415/1103 - (37%)	Gaps:	259/1103 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 CGSTLQSLDLSANKMVSLPTAMLSALGRLT-HLNMAKNSMSFLADRAFEGLLSLRVVDLSANRLT 271
            |.|.|.   .|...::||...::|:..:.| ..|:|..|...|.....:...::.|::|:.|:|.
Mouse     4 CSSYLM---YSFGGLLSLWILLVSSTNQCTVRYNVADCSHLKLTHIPDDLPSNITVLNLTHNQLR 65

  Fly   272 SLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFVGLKRLMM 336
            .|||..|....||..:....|||:.|.|.:...|..|.||:|..|||:.  |:..|||....|..
Mouse    66 RLPPTNFTRYSQLAILDAGFNSISKLEPELCQILPLLKVLNLQHNELSQ--ISDQTFVFCTNLTE 128

  Fly   337 LDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQ 401
            |||.:|.|.:::::.|:...:|..|.|..|.:.....|....|.||..|:|::|:|..:....|:
Mouse   129 LDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLSSTKLGTGVQLENLQELLLAKNKILALRSEELE 193

  Fly   402 GLKNLLVLSLD-------------FNRISRMDQRSLVNCSQLQD-------LHLNDNKLQAVPEA 446
            .|.|..:..||             |..|.:: ...|:|.:||..       ..|::..:|.:  :
Mouse   194 FLGNSSLRKLDLSSNPLKEFSPGCFQTIGKL-FALLLNNAQLNPHLTEKLCWELSNTSIQNL--S 255

  Fly   447 LAHVQLLKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKL 511
            ||:.|||.|   .|:..|.::.|::|||:..|      |:|..:..|.|..:.||:.|:|..|.:
Mouse   256 LANNQLLAT---SESTFSGLKWTNLTQLDLSY------NNLHDVGNGSFSYLPSLRYLSLEYNNI 311

  Fly   512 KSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNL-----VWLNISGNRLE--KFDYSHIPIG 569
            :.:...|....|.|:.:.|.....|....|.:. ||:     .||..    ||  ..|.::||
Mouse   312 QRLSPRSFYGLSNLRYLSLKRAFTKQSVSLASH-PNIDDFSFQWLKY----LEYLNMDDNNIP-- 369

  Fly   570 LQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIPNS-VEVLYLNDNQISKIQPY 633
                ..::|..|.|.:.    ..||||....|...||..|..|:.:| :..|.|..|.||||...
Mouse   370 ----STKSNTFTGLVSL----KYLSLSKTFTSLQTLTNETFVSLAHSPLLTLNLTKNHISKIANG 426

  Fly   634 TFFKKPNLTRVDL----VRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNR 694
            ||.....|..:||    :..:|:..|...|        |.|.|.|:.:|.|        ||....
Mouse   427 TFSWLGQLRILDLGLNEIEQKLSGQEWRGL--------RNIFEIYLSYNKY--------LQLSTS 475

  Fly   695 ESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPD 759
            .....|.|.       ||...|       :..|:
Mouse   476 SFALVPSLQ-------RLMLRR-------VALKN------------------------------- 495

  Fly   760 RCSCYHDQSWTSNVVDCSRASYEQTLPSHIPM-DSTQLYLDGNNFRELQSHAFIGRKRLKVLHLN 823
                          ||.|.:.:.       |: :.|.|.|..||...:......|.:.|::|...
Mouse   496 --------------VDISPSPFR-------PLRNLTILDLSNNNIANINEDLLEGLENLEILDFQ 539

  Fly   824 HSRIEVLHNRT--------FYGLLELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIATIDT 880
            |:.:..|..|.        ..||..|.:|.|:||.|..:....|:.|..|:.:.|..|.:..::.
Mouse   540 HNNLARLWKRANPGGPVNFLKGLSHLHILNLESNGLDEIPVGVFKNLFELKSINLGLNNLNKLEP 604

  Fly   881 LTFTHLYHLKILRLDHNAITSFAVWNFLPSY--LNELRLASNPWTCSCEFIDKLRDYINRHEYVV 943
            ..|.....|:.|.|..|.|||.....|.|.:  ||.|.:..||:.|:||.|....::||:....:
Mouse   605 FIFDDQTSLRSLNLQKNLITSVEKDVFGPPFQNLNSLDMRFNPFDCTCESISWFVNWINQTHTNI 669

  Fly   944 DKLKMKCDVISGNSTQQMVIYPGS--GEPASL-PVVQCSQTLPLGLDNNFNYAEQAGGENASNAT 1005
            .:|          ||..:...|..  |.|..| ....|..:.|..|
Mouse   670 SEL----------STHYLCNTPHHYYGFPLKLFDTSSCKDSAPFEL------------------- 705

  Fly  1006 STKMILNQPPKLDYIPILVAILTAFIFVMICISLVFIFRQEMRVWCHSRFGVRLFYNAQ------ 1064
                             |..|.|:.:.|.|.:.|:.    .:..|     .:..::|..
Mouse   706 -----------------LFIISTSMLLVFILVVLLI----HIEGW-----RISFYWNVSVHRILG 744

  Fly  1065 -KDVDKNEREKLFDAFVSYSSKDELFVNEELAPMLEMGEHRYKLCLHQRDFPVGGYLPETIVQAI 1128
             |::|....:..:.|::.::.||..:|.|..:||.|. :...|.||.:|||..|....|.||.:|
Mouse   745 FKEIDTQAEQFEYTAYIIHAHKDRDWVWEHFSPMEEQ-DQSLKFCLEERDFEAGVLGLEAIVNSI 808

  Fly  1129 DSSRRTIMVVSENFIKSEWC-RFEFKSAHQSVLRDRRRRLIVIVLGEVPQKELDPDL---RLYLK 1189
            ..||:.|.|::.:.:|...| ||:...|.|..:......:|:|.|..:|..:|:..|   |...|
Mouse   809 KRSRKIIFVITHHLLKDPLCRRFKVHHAVQQAIEQNLDSIILIFLQNIPDYKLNHALCLRRGMFK 873

  Fly  1190 TNTYLQWGDKLFWQKLRFALPDVSSSQRSNVAGQSCHVPINHASYHHHHHVHQQAMPLPHSVH 1252
            ::..|.|                               |:.....:..||..|.|:...:|.|
Mouse   874 SHCILNW-------------------------------PVQKERINAFHHKLQVALGSRNSAH 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	20/73 (27%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566	4/13 (31%)
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223	133/478 (28%)
		leucine-rich repeat	212..235	CDD:275380	5/22 (23%)
		leucine-rich repeat	236..259	CDD:275380	5/23 (22%)
		leucine-rich repeat	260..283	CDD:275380	8/22 (36%)
		LRR_RI	276..558	CDD:238064	84/306 (27%)
		leucine-rich repeat	284..307	CDD:275380	7/22 (32%)
		leucine-rich repeat	308..333	CDD:275380	11/24 (46%)
		leucine-rich repeat	334..357	CDD:275380	7/22 (32%)
		leucine-rich repeat	358..381	CDD:275380	6/22 (27%)
		leucine-rich repeat	382..405	CDD:275380	7/22 (32%)
		leucine-rich repeat	406..429	CDD:275380	6/35 (17%)
		leucine-rich repeat	430..452	CDD:275380	5/28 (18%)
		leucine-rich repeat	453..500	CDD:275380	13/46 (28%)
		leucine-rich repeat	501..521	CDD:275380	5/19 (26%)
		leucine-rich repeat	525..547	CDD:275380	4/21 (19%)
		leucine-rich repeat	548..573	CDD:275380	7/31 (23%)
		leucine-rich repeat	604..640	CDD:275380	14/36 (39%)
		leucine-rich repeat	641..688	CDD:275380	12/50 (24%)
		leucine-rich repeat	689..816	CDD:275380	18/127 (14%)
		LRR_8	815..875	CDD:290566	18/67 (27%)
		leucine-rich repeat	817..864	CDD:275380	15/54 (28%)
		LRR_8	864..921	CDD:290566	16/58 (28%)
		leucine-rich repeat	865..888	CDD:275380	4/22 (18%)
		leucine-rich repeat	889..910	CDD:275380	8/20 (40%)
		TIR	1076..1211	CDD:214587	39/138 (28%)
Tlr3	NP_001344245.1	leucine-rich repeat	37..53	CDD:275380	2/15 (13%)
		LRR 1	53..74		8/20 (40%)
		leucine-rich repeat	54..77	CDD:275380	8/22 (36%)
		PLN00113	70..>543	CDD:215061	144/583 (25%)
		LRR 2	77..98		7/20 (35%)
		leucine-rich repeat	78..101	CDD:275380	7/22 (32%)
		LRR 3	101..122		10/22 (45%)
		leucine-rich repeat	102..125	CDD:275380	11/24 (46%)
		LRR 4	125..146		7/20 (35%)
		leucine-rich repeat	126..149	CDD:275380	7/22 (32%)
		LRR 5	149..170		5/20 (25%)
		leucine-rich repeat	150..199	CDD:275380	15/48 (31%)
		LRR 6	173..196		7/22 (32%)
		LRR 7	199..220		3/20 (15%)
		leucine-rich repeat	200..250	CDD:275380	9/50 (18%)
		LRR 8	250..271		8/25 (32%)
		leucine-rich repeat	251..276	CDD:275380	9/29 (31%)
		LRR 9	276..297		8/26 (31%)
		leucine-rich repeat	277..300	CDD:275380	8/28 (29%)
		LRR 10	300..321		6/20 (30%)
		leucine-rich repeat	301..324	CDD:275380	5/22 (23%)
		LRR 11	324..345		4/21 (19%)
		leucine-rich repeat	325..381	CDD:275380	16/66 (24%)
		LRR 12	357..378		6/30 (20%)
		LRR 13	381..401		7/23 (30%)
		leucine-rich repeat	382..433	CDD:275380	19/54 (35%)
		LRR 14	409..430		9/20 (45%)
		LRR 15	433..454		5/20 (25%)
		leucine-rich repeat	434..458	CDD:275380	6/31 (19%)
		LRR 16	458..479		7/28 (25%)
		leucine-rich repeat	459..482	CDD:275380	7/30 (23%)
		LRR 17	482..502		8/78 (10%)
		leucine-rich repeat	483..508	CDD:275380	9/90 (10%)
		PPP1R42	503..>649	CDD:411060	40/152 (26%)
		LRR 18	508..529		5/20 (25%)
		leucine-rich repeat	509..532	CDD:275380	6/22 (27%)
		LRR 19	532..553		5/20 (25%)
		leucine-rich repeat	533..564	CDD:275380	7/30 (23%)
		LRR 20	564..585		7/20 (35%)
		leucine-rich repeat	565..586	CDD:275380	7/20 (35%)
		LRR 21	588..609		4/20 (20%)
		leucine-rich repeat	589..610	CDD:275378	4/20 (20%)
		LRR 22	612..633		8/20 (40%)
		leucine-rich repeat	613..637	CDD:275380	9/23 (39%)
		LRRCT	646..698	CDD:214507	15/61 (25%)
		Tlr3_TMD	699..731	CDD:407816	9/76 (12%)
		TIR	756..901	CDD:214587	44/176 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20696
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.780