Protein Alignment Tollo and LOC1270698

DIOPT Version :10

• Sequence 1: NP_524757.1
• Gene: Tollo / 44497
• FlyBaseID: FBgn0029114
• Length: 1346
• Species: Drosophila melanogaster
• Sequence 2: XP_061512685.1
• Gene: LOC1270698 / 1270698
• VectorBaseID: AGAMI1_014276
• Length: 728
• Species: Anopheles gambiae
• Alignment Length: 891
• Identity: 185/891 - (20%)
• Similarity: 301/891 - (33%)
• Gaps: 321/891 - (36%)

  Fly   522 NSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISGNRLEK------FDYSHIPIGLQWLDVRANRI 580
            |:.|:.:.:..|            |::.:||::.|::..      |.|.     |:.||:..||:
Mosquito    58 NASLEVVPIQLN------------PDVRYLNLTANQITNVHFTLAFYYQ-----LESLDLSHNRL 105

  Fly   581 TQLGNYFEIESELSLSTFDASYNLLTEITASSIP--NSVEVLYLNDNQISKIQPYTFFKKPNLTR 643
            ..||:. ..||:..|...:.::|:|..:...|..  ..:|:|.|.|||:.::.|..|....:|.|
Mosquito   106 DTLGSK-NFESQEKLLALNLTHNVLPALLKDSFRGLRRLELLRLGDNQLEQVHPTAFQSLVSLRR 169

  Fly   644 VDLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNRESRTQPQLMDLDQI 708
            ::|..|||.:.|...||  |:.                   :||.|...|.:....|...:|:
Mosquito   170 LELPNNRLVSFEEGVLR--PLV-------------------SLDTLLLANNQLLEVPYGGNLE-- 211

  Fly   709 HCRLAYARGSSHV----SLIE-AKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQS 768
                 |.|...|:    :||| ..:|.|...:..|...|       |.:..||.        |.|
Mosquito   212 -----YLRSLRHLDLSGNLIEFVANDSFGTLHQLHTLRL-------AGNVLMEL--------DWS 256

  Fly   769 WTSNVVDCSRASYEQTLPSHIP-------MDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNH-S 825
            ..|.:.............:.||       .:.|.|.|.||:|.||...||....:|:.|||:. .
Mosquito   257 GFSGLSALQLLDLADNNLTTIPTVQLAKLYNLTTLTLSGNSFVELPPVAFQNLFQLRELHLDRLD 321

  Fly   826 RIEVLHNRTFYGLLELEVLQLQSN-QLKALNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHL 889
            |:|.:..|.|.....|:||.|..| ....|....|.|..:|.::.::.||:.|:|.:.|.
Mosquito   322 RLEHIDTRAFIDNTHLQVLTLDDNPSFSTLPVRLFHGNPHLIDISMRRNALLTLDAVQFP----- 381

  Fly   890 KILRLDHNAITSFAVWNFLPSYLNELRLASNPWTCSC------------------------EFID 930
                ||.               |..|:||.||..|:|                        .|:.
Mosquito   382 ----LDR---------------LQRLKLAGNPLVCNCTIRWLWRLVTGTLDDDDGDDPDGVAFLG 427

  Fly   931 K-LRDYIN-RHEYVVDKLKMKCDV-ISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNNFNY 992
            | |.|:.| ....::||.::.||: ..|..|::::.....|:
Mosquito   428 KALADHTNITTVLLIDKDEIGCDLNEDGLVTRRILRNMSEGD----------------------- 469

  Fly   993 AEQAGGENASNATSTKMILNQPPKLDYIPILVAILTAFIFVMICISLVFIFRQEMRVWCHSRFGV 1057
                              :|.|.   ::..::::|.:.:.:.:......::|::.|
Mosquito   470 ------------------INCPA---HLVTVLSVLLSLLLLALGAGAAIVYRRKTR--------- 504

  Fly  1058 RLFYNAQKDVDKNEREKLFDAFVSYSSKDELFVNEELAPMLEMGEHRYKLCLHQRDFPVGGYLPE 1122
                         ||:|:.        ::...|:|.:.|     :...||.|.:       ||.:
Mosquito   505 -------------ERKKIL--------QERKNVHERIVP-----QKVDKLELER-------YLAQ 536

  Fly  1123 TIVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQKELDPDLRLY 1187
               |.:.:..|.:....:..::.: .::..::|||              |...|  ::|||...|
Mosquito   537 ---QVLSNDYRELRPACDLPVRYD-LKYPDQTAHQ--------------LAVAP--DVDPDSDHY 581

  Fly  1188 LKTNTYLQWGDKLFWQKLRFALPDVSSSQRSNVAGQSCHV-PIN--------------------- 1230
             :...|||....|            .||..||...||... |.:
Mosquito   582 -ENIDYLQHQRAL------------GSSTASNATTQSIITNPFHQQPPSQYHFLAQGQHPAAYQT 633

  Fly  1231 HASYHHHHHVHQQAMPLPHSVH-HHQQQFMLPPPP----QQPGSFRRQPSLHQQQQQQQQIRGNN 1290
            |..:|||||.|.   |..|..| |||||......|    |.|..:...|  |.|.........|:
Mosquito   634 HQPHHHHHHTHH---PTHHHPHPHHQQQQQTAAAPAMTMQHPHKYAHHP--HHQHAGADGAANNS 693

  Fly  1291 NTTQQQQQQQAALLMGGGSVGGPAPQMIPLAGGIQQQSLPLPPNQQ 1336
            ||                                    ||:||.|:
Mosquito   694 NT------------------------------------LPVPPGQR 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR	54..400	CDD:443914
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380
		LRR	239..634	CDD:443914	29/119 (24%)
		leucine-rich repeat	260..283	CDD:275380
		leucine-rich repeat	284..307	CDD:275380
		leucine-rich repeat	308..333	CDD:275380
		leucine-rich repeat	334..357	CDD:275380
		leucine-rich repeat	358..381	CDD:275380
		leucine-rich repeat	382..405	CDD:275380
		leucine-rich repeat	406..429	CDD:275380
		leucine-rich repeat	430..452	CDD:275380
		leucine-rich repeat	453..500	CDD:275380
		leucine-rich repeat	501..521	CDD:275380
		leucine-rich repeat	525..547	CDD:275380	2/21 (10%)
		leucine-rich repeat	548..573	CDD:275380	6/30 (20%)
		leucine-rich repeat	604..640	CDD:275380	10/37 (27%)
		LRR_8	616..>660	CDD:404697	15/43 (35%)
		leucine-rich repeat	641..688	CDD:275380	11/46 (24%)
		leucine-rich repeat	689..816	CDD:275380	32/138 (23%)
		LRR	<794..>920	CDD:443914	38/127 (30%)
		leucine-rich repeat	817..864	CDD:275380	16/48 (33%)
		leucine-rich repeat	865..888	CDD:275380	6/22 (27%)
		leucine-rich repeat	889..910	CDD:275380	2/20 (10%)
		TIR	1076..1211	CDD:214587	23/134 (17%)
LOC1270698	XP_061512685.1	None