DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tollo and Lrrtm2

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_821072.1	Gene:	Lrrtm2 / 107065	MGIID:	2389174	Length:	515	Species:	Mus musculus

Alignment Length:	368	Identity:	97/368 - (26%)
Similarity:	163/368 - (44%)	Gaps:	71/368 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 GMVCPLK-----------------------------SLQHLNASYNKIQDISNFYFSASLSSRKA 205
            ||.||.|                             ||:|     |.|..:....|::.
Mouse    31 GMACPPKCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRH-----NHITALERDQFASF------ 84

  Fly   206 RVCGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLRVVDLSANRL 270
                |.|..|.|..|::.::.......|.:|..|.::.|.:.:|.:..|..|::|:.:|||.|:|
Mouse    85 ----SQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQL 145

  Fly   271 TSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFVGLKRLM 335
            :||.||||...::||.::||:||:..:...:|.:...|..|||::|.|.|...|.  |.||.:|.
Mouse   146 SSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNG--FAGLIKLR 208

  Fly   336 MLDLSANKISRLE-AHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRT 399
            .|.|..|:::::. ||..| |:||..|.|:.|.|..|..|:....:.|..|.|:.|.|..|:...
Mouse   209 ELHLEHNQLTKINFAHFLR-LSSLHTLFLQWNKISNLTCGMDWTWSTLEKLDLTGNEIKAIDLTV 272

  Fly   400 LQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALA-------------HVQ 451
            .:.:.||.:|.:|.|:::.:|.:.|.:...|..:.|:.|..:..|...|             |..
Mouse   273 FETMPNLKILLMDNNKLNSLDSKILNSLKSLTTVGLSGNLWECSPRVCALASWLGSFQGRWEHSI 337

  Fly   452 LLKTLD--VGENMISQIE--------NTSITQLESLYGLRMTE 484
            |..:.|  .||:::..:.        :|::|.:.:.|....||
Mouse   338 LCHSPDHTQGEDILDAVHGFQLCWNLSTTVTAMATTYRDPTTE 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	35/139 (25%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566	16/80 (20%)
		leucine-rich repeat	154..177	CDD:275380	5/35 (14%)
		leucine-rich repeat	178..201	CDD:275380	5/22 (23%)
		LRR	210..656	CDD:227223	86/299 (29%)
		leucine-rich repeat	212..235	CDD:275380	5/22 (23%)
		leucine-rich repeat	236..259	CDD:275380	6/22 (27%)
		leucine-rich repeat	260..283	CDD:275380	12/22 (55%)
		LRR_RI	276..558	CDD:238064	65/233 (28%)
		leucine-rich repeat	284..307	CDD:275380	7/22 (32%)
		leucine-rich repeat	308..333	CDD:275380	11/24 (46%)
		leucine-rich repeat	334..357	CDD:275380	8/23 (35%)
		leucine-rich repeat	358..381	CDD:275380	7/22 (32%)
		leucine-rich repeat	382..405	CDD:275380	6/22 (27%)
		leucine-rich repeat	406..429	CDD:275380	6/22 (27%)
		leucine-rich repeat	430..452	CDD:275380	6/34 (18%)
		leucine-rich repeat	453..500	CDD:275380	8/42 (19%)
		leucine-rich repeat	501..521	CDD:275380
		leucine-rich repeat	525..547	CDD:275380
		leucine-rich repeat	548..573	CDD:275380
		leucine-rich repeat	604..640	CDD:275380
		leucine-rich repeat	641..688	CDD:275380
		leucine-rich repeat	689..816	CDD:275380
		LRR_8	815..875	CDD:290566
		leucine-rich repeat	817..864	CDD:275380
		LRR_8	864..921	CDD:290566
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
Lrrtm2	NP_821072.1	LRR 1	63..83		6/24 (25%)
		LRR	<65..312	CDD:227223	79/264 (30%)
		leucine-rich repeat	66..86	CDD:275380	6/34 (18%)
		LRR 2	86..107		4/20 (20%)
		leucine-rich repeat	87..110	CDD:275380	5/22 (23%)
		LRR 3	110..131		5/20 (25%)
		leucine-rich repeat	111..134	CDD:275380	6/22 (27%)
		LRR 4	134..155		12/20 (60%)
		leucine-rich repeat	135..158	CDD:275380	12/22 (55%)
		LRR 5	158..179		7/20 (35%)
		leucine-rich repeat	159..182	CDD:275380	7/22 (32%)
		LRR 6	182..203		9/22 (41%)
		leucine-rich repeat	183..206	CDD:275380	11/24 (46%)
		LRR 7	206..227		6/20 (30%)
		leucine-rich repeat	207..230	CDD:275380	8/23 (35%)
		LRR 8	230..251		8/20 (40%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		LRR 9	254..275		6/20 (30%)
		leucine-rich repeat	255..278	CDD:275380	6/22 (27%)
		LRR 10	278..299		7/20 (35%)
		leucine-rich repeat	279..300	CDD:275380	6/20 (30%)
		PCC	284..>351	CDD:188093	14/66 (21%)
		Involved in DLG4-binding. /evidence=ECO:0000250	512..515
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910