DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and tlr6

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	XP_017950845.1	Gene:	tlr6 / 100493946	XenbaseID:	XB-GENE-492949	Length:	842	Species:	Xenopus tropicalis

Alignment Length:	1060	Identity:	216/1060 - (20%)
Similarity:	390/1060 - (36%)	Gaps:	340/1060 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 ANKMVSLPTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLRVVDLSANRLTSLPPELFAETKQ 283
            :||.:......||:|  .|.|:::.||::.:....|..:..|:|::.|.|::..|...:|....|
Frog    31 SNKFLFAVPKNLSSL--TTVLDISFNSIATMETSEFNYIFDLQVLNASYNKMKYLNSSIFKFNTQ 93

  Fly   284 LQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFVGLKRLMMLDLSANKISRLE 348
            ||.:...:|.:..:: |.|.  :.:..||::.|  |.|.::..:  |...:::|:
Frog    94 LQYLDFSHNVLRNIS-GTFP--SHIQHLDISFN--NFQTLSVCS--GFGNMVLLE---------- 141

  Fly   349 AHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLH--TLILSRNRISVIEQRTLQGLKNLLVLSL 411
               :..|.:.||||.:           |..:.:||  .:.:..|.::..|..:|. |.|...|:|
Frog   142 ---YLGLGADQILKSD-----------FEGIVHLHLKEVFIELNSLNDYENGSLL-LLNTKKLTL 191

  Fly   412 DFNRISRMDQRSL----VNCSQLQDLHLNDNKLQAVPEALAHVQLLKT-LDVGENMISQIENTSI 471
            ||..:|..|:.::    ||.:.:.:              |:|:|.... :|..:.:.:.::|:.:
Frog   192 DFGVLSNEDRYNVLFDAVNTTSVLE--------------LSHLQRWNIHIDPKKYIFNIVQNSKV 242

  Fly   472 TQLESLY---GLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSL--QRNSQLQAIRLD 531
            |.|...:   ..:|...:|.:|..      ||::.|......||.:.|.:.  ..|:.::|:.:.
Frog   243 TDLTMRHVNVEWKMIVLALQYIWH------SSVETLTFYDFSLKGLIAKTSFDYSNTSVKAVNVQ 301

  Fly   532 GNQLKSIAGLFTELPNLVWLNISGNRLEKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLS 596
            |..:    |:|                 :||.|.:......:::. |......:...:...|:.|
Frog   302 GVNV----GVF-----------------QFDQSSVYRVFSNMNIE-NLTLNFASLLFMVCPLNSS 344

  Fly   597 TF---DASYNLLTEITASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLTTLEPNA 658
            ||   |.|:|.||:......                      |...||.|:.|.:|:|..:
Frog   345 TFQSIDFSHNALTDDLFKDC----------------------FTLINLKRLKLRKNKLEKI---- 383

  Fly   659 LRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSL 723
            .:||.:.|:                               .|.|..||..|..|||
Frog   384 YKLSAMTEN-------------------------------MPSLEYLDASHNLLAY--------- 408

  Fly   724 IEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTLPSH 788
               ..:|            ||                        |:.|:|:.:.||.
Frog   409 ---DEED------------CH------------------------WSQNIVELNLASN------- 427

  Fly   789 IPMDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKA 853
                    :|..:.|:.|.                               :.:::|.|:||.:..
Frog   428 --------FLTASIFKCLP-------------------------------ISIKILILESNDITH 453

  Fly   854 LNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAITSFAVWNFLP-SYLNELRL 917
            :... ...||:|.||.|..|.:.  |....:::..|.:|.::.|.|...::.:... |.:..:..
Frog   454 VPSG-VTHLDDLVELNLSFNRLG--DLPDCSNISSLSLLGVEGNQILYPSIESIESCSRVKHISA 515

  Fly   918 ASNPWTCSCEFIDKLRDYINRHEYVVDKLKMKCDVISGNSTQQMVIYPGS--GEPASLPVVQCSQ 980
            ..||:.|:||    ||.:||:.:..                      ||:  |.|.:   ..|
Frog   516 GQNPFQCNCE----LRRFINQEKEA----------------------PGTLIGWPEA---YVC-- 549

  Fly   981 TLPLGLDNNFNYAEQAGGENASNATSTKMILNQPPKLDYIPILVAILTAFIFVMICISLV----- 1040
                      .|.:...|....:...:::..|.     :|.|.|.||...|.:.:.|.|.
Frog   550 ----------KYPDHLRGTMLKDFYISEITCNV-----FILIPVIILPIIISIALIIGLCKYLDG 599

  Fly  1041 --FIFRQEMRVWCHSRFGVRL------FYNAQKDVDKNEREKLFDAFVSYSSKDELFVNEELAPM 1097
              |:    ..:|.::|...|.      :.:.|:|.|       |:||:|||..|..:|.....|.
Frog   600 PWFL----KMIWQYTRTKQRTRTSKQGYQSLQRDFD-------FNAFISYSEHDASWVKNIFLPS 653

  Fly  1098 LEMGEHRYKLCLHQRDFPVGGYLPETIVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRD 1162
            :|......::|.|:|:|..|..:.|.|:..|:.|.::|.::|.||::||||.:|...||..:..:
Frog   654 IERSNDCIRICQHERNFIPGKSIIENIINCIEKSYKSIFILSPNFVQSEWCHYELYFAHHKLYTE 718

  Fly  1163 RRRRLIVIVLGEVPQKELDPDLRLYLKT----NTYLQWGDK-----LFWQKLRFALP-------- 1210
            ....||:|:|..:|| .|.|.....|||    .|||:|..:     |||..||.|:.
Frog   719 NNDNLILILLEPIPQ-YLIPSKYYKLKTLMAQRTYLEWPSEKSKHGLFWANLRAAISIDLTHAES 782

  Fly  1211 ----DVSSSQRSNVAGQSCH 1226
                .:||....:::.::.|
Frog   783 EIPYSISSENPCSISSENPH 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	16/61 (26%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566	1/2 (50%)
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223	91/451 (20%)
		leucine-rich repeat	212..235	CDD:275380	5/15 (33%)
		leucine-rich repeat	236..259	CDD:275380	5/22 (23%)
		leucine-rich repeat	260..283	CDD:275380	6/22 (27%)
		LRR_RI	276..558	CDD:238064	56/293 (19%)
		leucine-rich repeat	284..307	CDD:275380	5/22 (23%)
		leucine-rich repeat	308..333	CDD:275380	6/24 (25%)
		leucine-rich repeat	334..357	CDD:275380	2/22 (9%)
		leucine-rich repeat	358..381	CDD:275380	5/22 (23%)
		leucine-rich repeat	382..405	CDD:275380	6/24 (25%)
		leucine-rich repeat	406..429	CDD:275380	8/26 (31%)
		leucine-rich repeat	430..452	CDD:275380	2/21 (10%)
		leucine-rich repeat	453..500	CDD:275380	7/50 (14%)
		leucine-rich repeat	501..521	CDD:275380	4/21 (19%)
		leucine-rich repeat	525..547	CDD:275380	4/21 (19%)
		leucine-rich repeat	548..573	CDD:275380	3/24 (13%)
		leucine-rich repeat	604..640	CDD:275380	3/35 (9%)
		leucine-rich repeat	641..688	CDD:275380	8/46 (17%)
		leucine-rich repeat	689..816	CDD:275380	19/126 (15%)
		LRR_8	815..875	CDD:290566	11/59 (19%)
		leucine-rich repeat	817..864	CDD:275380	5/46 (11%)
		LRR_8	864..921	CDD:290566	11/57 (19%)
		leucine-rich repeat	865..888	CDD:275380	6/22 (27%)
		leucine-rich repeat	889..910	CDD:275380	4/21 (19%)
		TIR	1076..1211	CDD:214587	51/155 (33%)
tlr6	XP_017950845.1	leucine-rich repeat	46..69	CDD:275378	5/22 (23%)
		LRR_8	70..125	CDD:404697	15/59 (25%)
		leucine-rich repeat	70..93	CDD:275378	6/22 (27%)
		leucine-rich repeat	94..114	CDD:275378	5/22 (23%)
		leucine-rich repeat	115..139	CDD:275378	6/27 (22%)
		LRR_RI	311..>478	CDD:423007	53/321 (17%)
		leucine-rich repeat	347..369	CDD:275380	6/43 (14%)
		leucine-rich repeat	370..395	CDD:275380	8/59 (14%)
		leucine-rich repeat	396..418	CDD:275380	11/69 (16%)
		leucine-rich repeat	419..440	CDD:275380	6/66 (9%)
		leucine-rich repeat	441..463	CDD:275380	5/22 (23%)
		leucine-rich repeat	464..485	CDD:275380	6/22 (27%)
		leucine-rich repeat	486..509	CDD:275380	4/22 (18%)
		LRRCT	518..570	CDD:214507	16/92 (17%)
		TIR	632..775	CDD:214587	51/143 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920