Protein Alignment Uba2 and NAE1

DIOPT Version :9

• Sequence 1: NP_524756.2
• Gene: Uba2 / 44496
• FlyBaseID: FBgn0029113
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001273429.1
• Gene: NAE1 / 8883
• HGNCID: 621
• Length: 537
• Species: Homo sapiens
• Alignment Length: 592
• Identity: 120/592 - (20%)
• Similarity: 196/592 - (33%)
• Gaps: 178/592 - (30%)

  Fly    14 QELVKKSKVLVVGAGGIGCEVLKNLVLSGFTDI---EIIDLDTIDLSNLNRQFLFHREHVGKSKA 75
            ||.::.:.|.::.|...|.|:||||||.|...|   .|||.:.:...:....|...|..:||::|
Human    25 QEALESAHVCLINATATGTEILKNLVLPGNVGIGSFTIIDGNQVSGEDAGNNFFLQRSSIGKNRA 89

  Fly    76 RVARESALSFNPDAKITAYHDSVTS-TDYGVNFFKKFDLVLSALDNRAARNHVNRMCLNADVPLI 139
            ..|.|.....|.|...:...:|..: .|...:||.:|.:|::.....:....:..:..|:.:||:
Human    90 EAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTVVVATQLPESTSLRLADVLWNSQIPLL 154

  Fly   140 ESGTAGYNGQVELIKRGLTQCYECTPKDKQRSFPGCTIRNTPSEPIHCIVWAKHLFNQLFGESLE 204
            ...|.|..|.:.:|                       |:..|       |...|..|.|
Human   155 ICRTYGLVGYMRII-----------------------IKEHP-------VIESHPDNAL------ 183

  Fly   205 DEDISPDAADPDAKEKDGGDGNGEPKGDGKEKGEESKEEKEAKEDTANGNIMRINTRQWAKDCNY 269
             ||:..|...|:.:|.             .:..:....||:....|....|:.....||..:.|.
Human   184 -EDLRLDKPFPELREH-------------FQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNG 234

  Fly   270 DAGKLFNKFFNEDITYLLRMSNLWKTRKAPVPVQ-------------WDTLLP---EGSSGDQK- 317
            ...|.:.:  .||...|:|...|.....||...:             ..|.:|   |....|.:
Human   235 RIPKTYKE--KEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRC 297

  Fly   318 -DVAKQHHKVWSIEECAQVFANSLKELSANFLKLEGDDTLAWDKDDQPAMDFVAACANVRSHIFD 381
             ::.||....|       :.|.:|||    |:..||...|.                 ||..|.|
Human   298 INITKQTPSFW-------ILARALKE----FVAKEGQGNLP-----------------VRGTIPD 334

  Fly   382 IERKSRFEIKSMAGNIIPAIATTNAITAGISVMRAFKVLEAKWEQCKAVYARLRPNARNHFLVPD 446
            :...|...||..  |:....|..:|...|..|.:..:.:....|.......:|
Human   335 MIADSGKYIKLQ--NVYREKAKKDAAAVGNHVAKLLQSIGQAPESISEKELKL------------ 385

  Fly   447 ASLPGPNPNCHVCASDPAITLKIDTKRMRIKELRDEVLVKTLN-------MLNPDVTVQSNGSIL 504
                       :|::...:.:      :|.:.|.:|..:.|:|       |.|||     |..:|
Human   386 -----------LCSNSAFLRV------VRCRSLAEEYGLDTINKDEIISSMDNPD-----NEIVL 428

  Fly   505 ---------ISSEEG--------ETECNDGKLLSELNIVDGVILKCDDFFQNYELSIIISHFDAE 552
                     ...::|        :.|.:.|||.|.|.          .|.|.|.||:::
Human   429 YLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLT----------GFLQEYGLSVMV------ 477

  Fly   553 RDENLFE 559
            :|:.:.|
Human   478 KDDYVHE 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uba2	NP_524756.2	ThiF	7..>177	CDD:279270	39/166 (23%)
		Uba2_SUMO	21..459	CDD:238766	92/459 (20%)
		UAE_UbL	467..552	CDD:291402	23/108 (21%)
		UBA2_C	573..691	CDD:292812
NAE1	NP_001273429.1	ThiF	9..>196	CDD:223552	49/207 (24%)
		APPBP1_RUB	11..535	CDD:238770	120/592 (20%)
		Interaction with UBA3	334..347		4/14 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810