DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uba2 and ULA1

DIOPT Version :9

Sequence 1:	NP_524756.2	Gene:	Uba2 / 44496	FlyBaseID:	FBgn0029113	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_015322.1	Gene:	ULA1 / 856104	SGDID:	S000005924	Length:	462	Species:	Saccharomyces cerevisiae

Alignment Length:	468	Identity:	89/468 - (19%)
Similarity:	158/468 - (33%)	Gaps:	139/468 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 QELVKKSKVLVVG-AGGIGCEVLKNLVLSGFTDIEIIDLDTI-------------DLSNLNRQFL 64
            |:.:.:|:|.||| |..:..||.|||||:|.:.:..:.::..             ||..|..:.|
Yeast    16 QDSLNRSRVCVVGPATPLLQEVFKNLVLAGISSLTWLKVECAVQSGSLFLAELKKDLEPLASKQL 80

  Fly    65 FHREHVGKSKARVARESALSFNPDAKITAYHDSVTSTDYGVNFFKKFDLVLSALDNRAAR---NH 126
            .:.|:                  |.:.|........|.:.|       ::|:.:..:.|.   |.
Yeast    81 EYEEN------------------DLRKTLQQPQYDWTRFSV-------VILTCIGEQTAMLDLNE 120

  Fly   127 VNRMCLNADVPLIESGTAGYNGQVELIKRGLTQCYECTPKDKQRSFPGCTIRNTPSEPIHCIVWA 191
            :.|.......|::.:..:|:.|.:.|:........:..|..|:...   .::|.         |.
Yeast   121 IRRQRGTKFPPVLNTFVSGFYGYIYLVLSETHFVLQAHPDSKKYDL---RLQNP---------WP 173

  Fly   192 KHLFNQLFGESLEDEDISPDAADP--------DAK-EKDGGDGNGEPKGDGKEK---------GE 238
            : |.|.:....|...|.:..:..|        .|| |:||  .||....|..:|         |.
Yeast   174 E-LINYVDTFDLSKMDTATFSGIPYTVLLMKCIAKLERDG--NNGRITIDQMKKVLDQICLPLGN 235

  Fly   239 ESKEEK---EAK----------------EDTANGNIMRINTRQWAKDCNYDAGKLFNKFFNEDIT 284
            :...|.   |||                ||......:......|....||           |.:|
Yeast   236 DVIYEPNYVEAKRYAYLACSQNDCCKELEDLLRNLEISDYGNDWHDTYNY-----------EILT 289

  Fly   285 YLLRMSNLWKTRKAPVPVQWDTLLPEGSSGDQKDVAKQHHKVWSIEEC-AQVFANSLKELSANFL 348
            .||.:.|:.|...   .:.:..|  .|:..|.:...:.:.::..:.|. |::..:.::|..|...
Yeast   290 LLLTLKNIAKENG---ELSFQPL--TGTLPDMESTTENYIRLKKLYEVKAKLDKSRVEESLARSK 349

  Fly   349 KLEGDDTLAWDKDDQPAMDFVAACANVRSHIFDIERKSRFEIKSMAGNIIPAIATTNAITAGISV 413
            |:...|.|.            ..|    ||..::.:     |.....:::...:|:||:...: |
Yeast   350 KIVSQDVLE------------TFC----SHYGEVRK-----ILPPKSDLLGIFSTSNALLDAL-V 392

  Fly   414 MRAFKVLEAKWEQ 426
            |..|      |||
Yeast   393 MVQF------WEQ 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba2	NP_524756.2	ThiF	7..>177	CDD:279270	34/179 (19%)
		Uba2_SUMO	21..459	CDD:238766	87/461 (19%)
		UAE_UbL	467..552	CDD:291402
		UBA2_C	573..691	CDD:292812
ULA1	NP_015322.1	E1_enzyme_family	2..460	CDD:304554	89/468 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810