DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uba2 and UBA2

DIOPT Version :9

Sequence 1:	NP_524756.2	Gene:	Uba2 / 44496	FlyBaseID:	FBgn0029113	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_010678.3	Gene:	UBA2 / 851998	SGDID:	S000002798	Length:	636	Species:	Saccharomyces cerevisiae

Alignment Length:	694	Identity:	225/694 - (32%)
Similarity:	362/694 - (52%)	Gaps:	111/694 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VKKSKVLVVGAGGIGCEVLKNLVLSGFTDIEIIDLDTIDLSNLNRQFLFHREHVGKSKARVARES 81
            ::.|:.|:|||||||.|:||:::|..|.:|.|:||||||||||||||||.::.:.:.|:..|.::
Yeast    19 LRSSRCLLVGAGGIGSELLKDIILMEFGEIHIVDLDTIDLSNLNRQFLFRQKDIKQPKSTTAVKA 83

  Fly    82 ALSFNPDAKITAYHDSVTS-TDYGVNFFKKFDLVLSALDNRAARNHVNRMCLNADVPLIESGTAG 145
            ...|| ::|:..|..:|.. :.:.:::|::||::.:||||.|||.:||::.....:|||||||||
Yeast    84 VQHFN-NSKLVPYQGNVMDISTFPLHWFEQFDIIFNALDNLAARRYVNKISQFLSLPLIESGTAG 147

  Fly   146 YNGQVELIKRGLTQCYECTPKDKQRSFPGCTIRNTPSEPIHCIVWAKH-LFNQLFGESLEDEDIS 209
            ::|.::.|..|.|:|:|||.|:..::||.||||:|||:|||||||||: ||||||.        |
Yeast   148 FDGYMQPIIPGKTECFECTKKETPKTFPVCTIRSTPSQPIHCIVWAKNFLFNQLFA--------S 204

  Fly   210 PDAADPDAKEKDGGDGNGEPKGDGKEKGEESKEEKEAKEDTANGNIMRINTRQWAKDCNYDAGKL 274
            ..:.:.|...:|.|..:.|   :.|...:|:.|..|.::...:.:..||             .::
Yeast   205 ETSGNEDDNNQDWGTDDAE---EIKRIKQETNELYELQKIIISRDASRI-------------PEI 253

  Fly   275 FNKFFNEDITYLLRMSNLWKTRKAPVPVQWDTLLPEGSSGDQKDVAKQHHKVWSIEECAQVFANS 339
            .||.|.:||..||.:.||||||..|||:. |:.:    :...|......:.|.:|:|....|.|.
Yeast   254 LNKLFIQDINKLLAIENLWKTRTKPVPLS-DSQI----NTPTKTAQSASNSVGTIQEQISNFINI 313

  Fly   340 LKELSANFLKLEGDDTLAWDKDDQPAMDFVAACANVRSHIFDIERKSRFEIKSMAGNIIPAIATT 404
            .::|...:.|.:  :.:.:||||...::|||..||:|||||:|..||.|:||.:|||||||||||
Yeast   314 TQKLMDRYPKEQ--NHIEFDKDDADTLEFVATAANIRSHIFNIPMKSVFDIKQIAGNIIPAIATT 376

  Fly   405 NAITAGISVMRAFKVLE-------AKWEQCKAVYARLRPNARNHFLVPDASLPGPNPNCHVCASD 462
            |||.||.|.:.:.:||.       .|:......:.....|...:..:.:..|..||.||.||:..
Yeast   377 NAIVAGASSLISLRVLNLLKYAPTTKYTDLNMAFTAKASNLSQNRYLSNPKLAPPNKNCPVCSKV 441

  Fly   463 PAITLKIDTKRMRIKELRD-EVLVKTLNMLNPDVTV--QSNGSILISSEEGETECNDGKLLSELN 524
            ....:|:.:..:...:|.| .||::.......|:::  .||..:|...:  ..:.|| :.|||:|
Yeast   442 CRGVIKLSSDCLNKMKLSDFVVLIREKYSYPQDISLLDASNQRLLFDYD--FEDLND-RTLSEIN 503

  Fly   525 IVDGVILKCDDFFQNYELSIIISHFDAERDE------NLFEVVADASQLKPKDEDQKEAVKDKED 583
            :.:|.|:...|...:..:...|..|....||      :|.:|  :...:|..:...|     .|:
Yeast   504 LGNGSIILFSDEEGDTMIRKAIELFLDVDDELPCNTCSLPDV--EVPLIKANNSPSK-----NEE 561

  Fly   584 EPKSAK----KRSTNGEGDSKDDGPSTSKRSRPNEVVEEDDDDCLVIEEDEDQADVVVVATDKLS 644
            |.|:.|    ..:||..|                      .|..:::::||.:          ::
Yeast   562 EEKNEKGADVVATTNSHG----------------------KDGIVILDDDEGE----------IT 594

  Fly   645 VQSPPKSGSKRKPCEVIEDEDITEILESSDDEPAGPTKCKRSRL 688
            :.:.|.:|||::|.:       |||.|:..:        ||::|
Yeast   595 IDAEPINGSKKRPVD-------TEISEAPSN--------KRTKL 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba2	NP_524756.2	ThiF	7..>177	CDD:279270	72/160 (45%)
		Uba2_SUMO	21..459	CDD:238766	174/446 (39%)
		UAE_UbL	467..552	CDD:291402	20/87 (23%)
		UBA2_C	573..691	CDD:292812	23/120 (19%)
UBA2	NP_010678.3	Uba2_SUMO	23..438	CDD:238766	174/446 (39%)
		UBA_e1_thiolCys	183..>370	CDD:402288	76/217 (35%)
		UAE_UbL	453..518	CDD:423033	17/67 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346471
Domainoid	1	1.000	286	1.000	Domainoid score	I246
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4018
Inparanoid	1	1.050	305	1.000	Inparanoid score	I491
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54272
OrthoFinder	1	1.000	-	-		FOG0004682
OrthoInspector	1	1.000	-	-		oto99885
orthoMCL	1	0.900	-	-		OOG6_101769
Panther	1	1.100	-	-	LDO	PTHR10953
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2782
SonicParanoid	1	1.000	-	-		X3290
TreeFam	1	0.960	-	-
	15	14.790