Protein Alignment Uba2 and Nae1

DIOPT Version :10

• Sequence 1: NP_524756.2
• Gene: Uba2 / 44496
• FlyBaseID: FBgn0029113
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_114461.3
• Gene: Nae1 / 84019
• RGDID: 619945
• Length: 534
• Species: Rattus norvegicus
• Alignment Length: 591
• Identity: 121/591 - (20%)
• Similarity: 205/591 - (34%)
• Gaps: 179/591 - (30%)

  Fly    14 QELVKKSKVLVVGAGGIGCEVLKNLVLSGFTDIEIIDLDTIDLSNLNRQFLFHREHVGKSKARVA 78
            ||.::.:.|.::.|...|.|:||||||.|.....|||.:.:...::...|...:..:||::|:.|
  Rat    25 QEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDVGNNFFLQKCSIGKNRAQAA 89

  Fly    79 RESALSFNPDAKITAYHDSVTS-TDYGVNFFKKFDLVLSA--LDNRAARNHVNRMCLNADVPLIE 140
            .|.....|.|...:...:|..: .|...:||.:|.:|::.  |::...|  :..:..|:.:||:.
  Rat    90 MEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTIVVATQLLESTLLR--LADVLWNSQIPLLI 152

  Fly   141 SGTAGYNGQVELIKRGLTQCYECTPKDKQRSFPGCTIRNTPSEPIHCIVWAKHLFNQLFGESLED 205
            ..|.|..|.:.:|                       |:..|       |...|..|.|
  Rat   153 CRTYGLVGYMRII-----------------------IKEHP-------VIESHPDNAL------- 180

  Fly   206 EDISPDAADPDAKEKDGGDGNGEPKGDGKEKGEESKEEKEAKEDTANGNIMRINTRQWAKDCNYD 270
            ||:..|...|:.:|.             .:..:....||:....|....|:.....||..:.|..
  Rat   181 EDLRLDKPFPELREH-------------FQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGR 232

  Fly   271 AGKLFNKFFNEDITYLLRMSNLWKTRKAPVPVQ-------------WDTLLP---EGSSGDQK-- 317
            ..|.:.:  .||...|:|...|.....||...:             ..|.:|   |....|.:
  Rat   233 IPKSYKE--KEDFRELIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCI 295

  Fly   318 DVAKQHHKVWSIEECAQVFANSLKELSANFLKLEGDDTLAWDKDDQPAMDFVAACANVRSHIFDI 382
            ::.||....|       :.|.:|||    |:..||...|.                 ||..|.|:
  Rat   296 NITKQTPSFW-------ILARALKE----FVAKEGQGNLP-----------------VRGTIPDM 332

  Fly   383 ERKSRFEIKSMAGNIIPAIATTNAITAGISVMRAFKVLEAKWEQCKAVYARLRPNARNHFLVPDA 447
            ...|...||..  |:....|..:|...|..|.   |:|::..:..:::..:            :.
  Rat   333 IADSSKYIKLQ--NVYREKAKKDAAAVGNHVA---KLLQSVGQAPESISEK------------EL 380

  Fly   448 SLPGPNPNCHVCASDPAITLKIDTKRMRIKELRDEVLVKTLN-------MLNPDVTVQSNGSIL- 504
            .|        :|::...:.:      :|.:.|.:|..:.|:|       |.|||     |..:|
  Rat   381 KL--------LCSNSAFLRV------VRCRSLAEEYGLHTVNKDEIISSMDNPD-----NEIVLY 426

  Fly   505 --------ISSEEG--------ETECNDGKLLSELNIVDGVILKCDDFFQNYELSIIISHFDAER 553
                    ...:.|        :.|.:.|||.|.|.          .|.|.|.||:::      :
  Rat   427 LMLRAVDRFHKQHGRYPGVSNYQVEEDIGKLKSCLT----------GFLQEYGLSVMV------K 475

  Fly   554 DENLFE 559
            |:.:.|
  Rat   476 DDYVHE 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uba2	NP_524756.2	Uba2_SUMO	21..459	CDD:238766	93/458 (20%)
		UAE_UbL	467..552	CDD:464286	23/108 (21%)
Nae1	NP_114461.3	APPBP1_RUB	11..532	CDD:238770	121/591 (20%)
		Interaction with UBA3. /evidence=ECO:0000250	331..344		4/14 (29%)