DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uba2 and UBA5

DIOPT Version :9

Sequence 1:	NP_524756.2	Gene:	Uba2 / 44496	FlyBaseID:	FBgn0029113	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_079094.1	Gene:	UBA5 / 79876	HGNCID:	23230	Length:	404	Species:	Homo sapiens

Alignment Length:	384	Identity:	89/384 - (23%)
Similarity:	146/384 - (38%)	Gaps:	106/384 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ELVKKSKVLVVGAGGIGCEVLKNLVLSGFTDIEIIDLDTIDLSNLNRQFLFHREHVGKSKARVAR 79
            |.::...|.:||.||:|....:.|...|...:.:.|.|.::|:|:||.| |.....|.||.:.|.
Human    69 EKIRTFAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLF-FQPHQAGLSKVQAAE 132

  Fly    80 ESALSFNPDAKITAYHDSVTSTDYGVNFF-----------KKFDLVLSALDNRAARNHVNRMCLN 133
            .:..:.|||.....::.::|:.:...:|.           |..|||||.:||..||..:|..|..
Human   133 HTLRNINPDVLFEVHNYNITTVENFQHFMDRISNGGLEEGKPVDLVLSCVDNFEARMTINTACNE 197

  Fly   134 ADVPLIESGTA--GYNGQVELIKRGLTQCYECTP----------KDKQR------SFP------- 173
            .....:|||.:  ..:|.::||..|.:.|:.|.|          |..:|      |.|
Human   198 LGQTWMESGVSENAVSGHIQLIIPGESACFACAPPLVVAANIDEKTLKREGVCAASLPTTMGVVA 262

  Fly   174 GCTIRNTPSEPIHCIVWAKHLFNQLFG--------ESLED------EDISPDAADPDAKEKDGGD 224
            |..::|.          .|.|.|  ||        .:::|      ...:|...|.:.:::   .
Human   263 GILVQNV----------LKFLLN--FGTVSFYLGYNAMQDFFPTMSMKPNPQCDDRNCRKQ---Q 312

  Fly   225 GNGEPKGDGKEKGEESKEEKE-AKEDTANGNIMRINTRQWAKDCNYDAGKLFNKFFNEDITYLLR 288
            ...:.|.....|.|..:||:| ..||           .:|..:       |.::...|::
Human   313 EEYKKKVAALPKQEVIQEEEEIIHED-----------NEWGIE-------LVSEVSEEEL----- 354

  Fly   289 MSNLWKTRKAPVPVQWDTLLPEGSSGDQKDVAKQHHKV--WSIEECAQVFANSLKELSA 345
                 |....|||.     ||||.:.......||...|  .::|:..:    ||::|.|
Human   355 -----KNFSGPVPD-----LPEGITVAYTIPKKQEDSVTELTVEDSGE----SLEDLMA 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba2	NP_524756.2	ThiF	7..>177	CDD:279270	53/197 (27%)
		Uba2_SUMO	21..459	CDD:238766	88/378 (23%)
		UAE_UbL	467..552	CDD:291402
		UBA2_C	573..691	CDD:292812
UBA5	NP_079094.1	ThiF_MoeB_HesA_family	52..297	CDD:238386	60/240 (25%)
UBA5	NP_079094.1	UFM1-interacting sequence (UIS). /evidence=ECO:0000269\|PubMed:26929408, ECO:0000269\|PubMed:27653677	334..346		3/29 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810