DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uba2 and uba2

DIOPT Version :9

Sequence 1:	NP_524756.2	Gene:	Uba2 / 44496	FlyBaseID:	FBgn0029113	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001017091.1	Gene:	uba2 / 549845	XenbaseID:	XB-GENE-977709	Length:	641	Species:	Xenopus tropicalis

Alignment Length:	682	Identity:	326/682 - (47%)
Similarity:	438/682 - (64%)	Gaps:	65/682 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AINGVFPPTLQELVKKSKVLVVGAGGIGCEVLKNLVLSGFTDIEIIDLDTIDLSNLNRQFLFHRE 68
            |:.|..|..|.|.|..|::|||||||||||:||||||:||.::::|||||||:|||||||||.::
Frog     2 AMIGALPKELAEAVSTSRLLVVGAGGIGCELLKNLVLTGFINLDVIDLDTIDVSNLNRQFLFQKK 66

  Fly    69 HVGKSKARVARESALSFNPDAKITAYHDSVTSTDYGVNFFKKFDLVLSALDNRAARNHVNRMCLN 133
            |||:|||:||:||.|.|.|:|.|||||||:.:.||.|.|||:|.:|::||||.|||||||||||.
Frog    67 HVGRSKAQVAKESVLQFCPEANITAYHDSIMNPDYNVEFFKQFTMVMNALDNNAARNHVNRMCLA 131

  Fly   134 ADVPLIESGTAGYNGQVELIKRGLTQCYECTPKDKQRSFPGCTIRNTPSEPIHCIVWAKHLFNQL 198
            |.:||||||||||.|||.::|:|:|:||||.||..|::|||||||||||||||||||||:|||||
Frog   132 AGIPLIESGTAGYLGQVTVVKKGVTECYECQPKPTQKTFPGCTIRNTPSEPIHCIVWAKYLFNQL 196

  Fly   199 FGESLEDEDISPDAADPDAKEKDGGDGNGEPKGDGKEKGEESKEEKEAKEDTANGNIMRINTRQW 263
            |||...|::::||.|||:|                  ..:.::..:.|.....:|:|.|::|:||
Frog   197 FGEEDADQEVAPDIADPEA------------------AWDPTQAAERANASNVDGDIKRVSTKQW 243

  Fly   264 AKDCNYDAGKLFNKFFNEDITYLLRMSNLWKTRKAPVPVQWDTL-LPEGSSGDQKDVAKQ---HH 324
            ||...||..|||||.|.:||.|||.|..||:.||.|||::|.:| ..|..|..|.:.:.|   ..
Frog   244 AKSTGYDPIKLFNKLFRDDIKYLLTMDRLWRKRKPPVPLEWSSLHNKENCSETQNESSLQGLKDQ 308

  Fly   325 KVWSIEECAQVFANSLKELSANFLKLEGDDTLAWDKDDQPAMDFVAACANVRSHIFDIERKSRFE 389
            ||..:..|||:|:.|::.|.....:......|.|||||.||||||.|.||:|.|||.:..||||:
Frog   309 KVLDVTSCAQLFSKSVETLREQLREKGNGAELVWDKDDPPAMDFVTAAANLRMHIFSMNMKSRFD 373

  Fly   390 IKSMAGNIIPAIATTNAITAGISVMRAFKVLEAKWEQCKAVYARLRPNARNHFLVPDASLPGPNP 454
            :||||||||||||||||:.:|:.|:...|:|....|||:.|:...:||.|...||| .||..|||
Frog   374 VKSMAGNIIPAIATTNAVISGLIVLEGLKILSGNTEQCRTVFLNKQPNPRKKLLVP-CSLDPPNP 437

  Fly   455 NCHVCASDPAITLKIDTKRMRIKELRDEVLVKTLNMLNPDVTVQ-SNGSILISSEEGETECNDGK 518
            :|:|||..|.:|:|::..::.::.|:|::|.:...|:.|||.:: ..|:||||||.|||:.|:.:
Frog   438 SCYVCAIKPEVTVKLNVHKVTVQMLQDKILKEKFAMVAPDVQIEDGKGTILISSEAGETDANNNR 502

  Fly   519 LLSELNIVDGVILKCDDFFQNYELSIIISHFDAERDENLFEVVADASQLKPKDEDQKEAVKDKED 583
            .:||..|.:...|:.|||.|:|.|.|.|.|.|....:..||||.|..:..|:...::..
Frog   503 KISEFGIRNSSQLQADDFLQDYTLMINILHSDEMEKDVDFEVVGDVPEKGPQKPSEQSV------ 561

  Fly   584 EPKSAKKRSTNGEGDSKDDG--PSTSKRSRPNEVVEEDDDDCLVIEEDED-----QADVVVVATD 641
                  |..|||    .|||  |||||        .:|.||.|:::.||:     .||:.:   |
Frog   562 ------KNITNG----SDDGAQPSTSK--------AQDQDDVLIVDSDEESPSSSNADINM---D 605

  Fly   642 KLSVQS--PPK---SGSKRKPCE--VIEDEDI 666
            ..|::.  |.:   |.:|||..|  |.||:||
Frog   606 SASLKRKLPEEETISSTKRKRLEPPVEEDDDI 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba2	NP_524756.2	ThiF	7..>177	CDD:279270	113/169 (67%)
		Uba2_SUMO	21..459	CDD:238766	242/441 (55%)
		UAE_UbL	467..552	CDD:291402	33/85 (39%)
		UBA2_C	573..691	CDD:292812	33/108 (31%)
uba2	NP_001017091.1	Uba2_SUMO	19..442	CDD:238766	242/441 (55%)
		UBA_e1_thiolCys	179..360	CDD:371150	86/198 (43%)
		UAE_UbL	450..536	CDD:373253	33/85 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	546..641		35/119 (29%)
		UBA2_C	549..636	CDD:374424	32/113 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	486	1.000	Domainoid score	I393
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4018
Inparanoid	1	1.050	603	1.000	Inparanoid score	I928
OMA	1	1.010	-	-		QHG54272
OrthoDB	1	1.010	-	-		D436007at33208
OrthoFinder	1	1.000	-	-		FOG0004682
OrthoInspector	1	1.000	-	-		oto104386
Panther	1	1.100	-	-	LDO	PTHR10953
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2782
SonicParanoid	1	1.000	-	-		X3290
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110