DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uba2 and Uba2

DIOPT Version :9

Sequence 1:	NP_524756.2	Gene:	Uba2 / 44496	FlyBaseID:	FBgn0029113	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_057891.1	Gene:	Uba2 / 50995	MGIID:	1858313	Length:	638	Species:	Mus musculus

Alignment Length:	705	Identity:	333/705 - (47%)
Similarity:	448/705 - (63%)	Gaps:	76/705 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AINGVFPPTLQELVKKSKVLVVGAGGIGCEVLKNLVLSGFTDIEIIDLDTIDLSNLNRQFLFHRE 68
            |::...|..|.|.|...:||||||||||||:||||||:||:.|::|||||||:|||||||||.::
Mouse     2 ALSRGLPRELAEAVSGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKK 66

  Fly    69 HVGKSKARVARESALSFNPDAKITAYHDSVTSTDYGVNFFKKFDLVLSALDNRAARNHVNRMCLN 133
            |||:|||:||:||.|.|:|.|.|.|:|||:.:.||.|.||::|.||::||||||||||||||||.
Mouse    67 HVGRSKAQVAKESVLQFHPQANIEAHHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRMCLA 131

  Fly   134 ADVPLIESGTAGYNGQVELIKRGLTQCYECTPKDKQRSFPGCTIRNTPSEPIHCIVWAKHLFNQL 198
            |||||||||||||.|||..||:|:|:||||.||..||:|||||||||||||||||||||:|||||
Mouse   132 ADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPSEPIHCIVWAKYLFNQL 196

  Fly   199 FGESLEDEDISPDAADPDAKEKDGGDGNGEPKGDGKEKGEESKEEKEAKEDTANGNIMRINTRQW 263
            |||...|:::|||.|||:|                  ..|.::.|..|:....:|:|.||:|::|
Mouse   197 FGEEDADQEVSPDRADPEA------------------AWEPTEAEARARASNEDGDIKRISTKEW 243

  Fly   264 AKDCNYDAGKLFNKFFNEDITYLLRMSNLWKTRKAPVPVQWDTLLPEG-SSGDQKD---VAKQHH 324
            ||...||..|||.|.|.:||.|||.|..||:.||.|||:.|..:..:| ::.||::   :..:..
Mouse   244 AKSTGYDPVKLFTKLFKDDIRYLLTMDKLWRKRKPPVPLDWAEVQSQGEANADQQNEPQLGLKDQ 308

  Fly   325 KVWSIEECAQVFANSLKELSANFLKLEGDDT-LAWDKDDQPAMDFVAACANVRSHIFDIERKSRF 388
            :|..::..|.:|:.|::.|..: |..:||.. |.|||||.||||||.:.||:|.|||.:..||||
Mouse   309 QVLDVKSYASLFSKSIETLRVH-LAEKGDGAELIWDKDDPPAMDFVTSAANLRMHIFSMNMKSRF 372

  Fly   389 EIKSMAGNIIPAIATTNAITAGISVMRAFKVLEAKWEQCKAVYARLRPNARNHFLVPDASLPGPN 453
            :|||||||||||||||||:.||:.|:...|:|..|.:||:.::...:||.|...||| .:|..||
Mouse   373 DIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNKQPNPRKKLLVP-CALDPPN 436

  Fly   454 PNCHVCASDPAITLKIDTKRMRIKELRDEVLVKTLNMLNPDVTVQ-SNGSILISSEEGETECNDG 517
            .||:||||.|.:|::::..::.:..|:|:::.:...|:.|||.:: ..|:|||||||||||.|:.
Mouse   437 TNCYVCASKPEVTVRLNVHKVTVLTLQDKIVKEKFAMVAPDVQIEDGKGTILISSEEGETEANNP 501

  Fly   518 KLLSELNIVDGVILKCDDFFQNYELSIIISHFDAERDENLFEVVADASQLKPKDEDQKEAVKDKE 582
            |.||:..|.:|..|:.|||.|:|.|.|.|.|.:....:..||||.|:        .:|...|..|
Mouse   502 KKLSDFGIRNGSRLQADDFLQDYTLLINILHSEDLGKDVEFEVVGDS--------PEKVGPKQAE 558

  Fly   583 DEPKSAKKRSTNGEGDSKDDG--PSTSKRSRPNEVVEEDDDDCLVIEEDEDQADVVVVATDKLSV 645
            |..||.    .||    .|||  ||||        ..::.||.|:::.||:...   .:||
Mouse   559 DAAKSI----ANG----SDDGAQPSTS--------TAQEQDDVLIVDSDEEGPS---NSTD---- 600

  Fly   646 QSPPKSGSKRKPCEVIEDEDITEILESSDDEPAGPTKCKRSRLDDSNPVAVISID 700
            .|......|||             ||  ::|.|...||:..:::|  |..||::|
Mouse   601 CSGDDKARKRK-------------LE--ENEAASTKKCRLEQMED--PDDVIALD 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba2	NP_524756.2	ThiF	7..>177	CDD:279270	116/169 (69%)
		Uba2_SUMO	21..459	CDD:238766	246/442 (56%)
		UAE_UbL	467..552	CDD:291402	34/85 (40%)
		UBA2_C	573..691	CDD:292812	32/119 (27%)
Uba2	NP_057891.1	ThiF	9..>175	CDD:279270	115/165 (70%)
		Uba2_SUMO	19..442	CDD:238766	238/427 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..233		8/30 (27%)
		UAE_UbL	450..536	CDD:291402	38/86 (44%)
		UBA2_C	547..633	CDD:292812	25/87 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	548..638		25/91 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850010
Domainoid	1	1.000	482	1.000	Domainoid score	I407
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4018
Inparanoid	1	1.050	591	1.000	Inparanoid score	I986
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54272
OrthoDB	1	1.010	-	-		D686413at2759
OrthoFinder	1	1.000	-	-		FOG0004682
OrthoInspector	1	1.000	-	-		oto94180
orthoMCL	1	0.900	-	-		OOG6_101769
Panther	1	1.100	-	-	LDO	PTHR10953
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2782
SonicParanoid	1	1.000	-	-		X3290
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800