DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uba2 and uba1

DIOPT Version :9

Sequence 1:	NP_524756.2	Gene:	Uba2 / 44496	FlyBaseID:	FBgn0029113	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_998227.1	Gene:	uba1 / 406335	ZFINID:	ZDB-GENE-040426-2009	Length:	1058	Species:	Danio rerio

Alignment Length:	493	Identity:	143/493 - (29%)
Similarity:	218/493 - (44%)	Gaps:	87/493 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VFPPTLQELVKKSKVLVVGAGGIGCEVLKNLVL----SGFTDIEIIDLDTIDLSNLNRQFLFHRE 68
            ||...||||:.|.:..:||||.||||:|||..:    ||..::.:.|:|||:.|||||||||...
Zfish   458 VFGSKLQELLAKQRYFLVGAGAIGCELLKNFAMMGLASGEGEVIVTDMDTIEKSNLNRQFLFRPW 522

  Fly    69 HVGKSKARVARESALSFNPDAKITAYHDSV---TSTDYGVNFFKKFDLVLSALDNRAARNHVNRM 130
            .|.|.|:..|..:....||..:||.:.:.|   |...|..:||:..|.|.:||||..||.:::|.
Zfish   523 DVTKMKSETAAAAVKQMNPSVRITGHQNRVGPDTEKVYDDDFFECLDGVANALDNVDARMYMDRR 587

  Fly   131 CLNADVPLIESGTAGYNGQVELIKRGLTQCYECTPKDKQRSFPGCTIRNTPSEPIHCIVWAKHLF 195
            |:....||:||||.|..|.|:::...:|:.|..:....::|.|.||::|.|:...|.:.||:..|
Zfish   588 CVYYRKPLLESGTLGTKGNVQVVIPFITESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEF 652

  Fly   196 NQLFGESLEDEDISPDAADPDAKEKDGGDGNGEPKGDGKEKGEESKEEKEAKEDTANGNIMRINT 260
            ..||.:..  |:......|....|:           ..|..|.:..|..|    :...:::....
Zfish   653 EGLFKQPA--ENALQYLTDSKFMER-----------TLKLPGAQPLEVVE----SVYKSLVTDRP 700

  Fly   261 RQWAKDC------------NYDAGKLFNKFFNEDIT----------------------------Y 285
            |.| .||            |.:..:|.:.|..:.:|                            |
Zfish   701 RNW-DDCVTWARNHWQCQYNNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLEFSTNNDLHMDY 764

  Fly   286 LLRMSNLW---------KTRKAPVPVQWDTLLPEGSSGDQKDVAKQHHKVWSIEEC-AQVFANSL 340
            :|..:||:         ..|.|...:..|..:||.:   .|...|.|.....::.. |.|..:.|
Zfish   765 ILAAANLYALSYGLPSCNDRSALTKLLQDIKVPEFT---PKSGVKIHVSDQELQSANASVDDSRL 826

  Fly   341 KELSANFLKLEGDD-----TLAWDKDDQP--AMDFVAACANVRSHIFDIERKSRFEIKSMAGNII 398
            :||......||...     .:.::|||..  .|||:.|.:|:|:..:||....|.:.|.:||.||
Zfish   827 EELKTLLPSLEASSQFKLCPIEFEKDDDTNFHMDFIVAASNLRAENYDIPPADRHKSKLIAGKII 891

  Fly   399 PAIATTNAITAGISVMRAFKVLEA--KWEQCKAVYARL 434
            ||||||.|...|:..:...|:::.  |.|..|..:..|
Zfish   892 PAIATTTAAVVGLVCLELLKIVQGHKKLESYKNGFMNL 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba2	NP_524756.2	ThiF	7..>177	CDD:279270	70/175 (40%)
		Uba2_SUMO	21..459	CDD:238766	136/480 (28%)
		UAE_UbL	467..552	CDD:291402
		UBA2_C	573..691	CDD:292812
uba1	NP_998227.1	Ube1	49..1055	CDD:273603	143/493 (29%)
		Ube1_repeat1	54..436	CDD:238768
		E1_4HB	303..366	CDD:292809
		Ube1_repeat2	471..1011	CDD:238767	136/480 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810