DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uba2 and APP-BP1

DIOPT Version :9

Sequence 1:	NP_524756.2	Gene:	Uba2 / 44496	FlyBaseID:	FBgn0029113	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001261699.1	Gene:	APP-BP1 / 39244	FlyBaseID:	FBgn0261112	Length:	524	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	126/545 - (23%)
Similarity:	201/545 - (36%)	Gaps:	153/545 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 QELVKKSKVLVVGAGGIGCEVLKNLVLSGFTDIEIIDLDTIDLSNLNRQFLFHREHVGKSKARVA 78
            |.|::.:.|.:|....:|||..|.|||.|.....:.|..|:...:|...|.....::|||||...
  Fly    30 QTLLEAATVCLVNVTAVGCETAKGLVLPGIGGFTVADGSTVKEEDLGNNFFLDSSYLGKSKALAC 94

  Fly    79 RESALSFNPDAKITAYHDSVTSTDYGV----NFFKKFDLVLSALDNRAARNHVNRMCLNADVPLI 139
            .:.....|||.. ..|.|.  |.|:.:    |||..||||:::..|......:.......:||||
  Fly    95 MQLLQELNPDVN-GDYVDE--SADFLLANRPNFFDSFDLVIASNLNEQTLLLLAERLWELNVPLI 156

  Fly   140 ESGTAGYNGQVELIKRGLTQCYECTPKDKQRSFPGCTIRNTPSEPIHCIVWAKHLFNQLFGESLE 204
            ...:.|..|.:.|                       .||.      ||||.| |..|:.|...||
  Fly   157 YCRSLGMLGTIRL-----------------------QIRE------HCIVEA-HPDNRQFDLRLE 191

  Fly   205 D------EDISPDAADPDAK--------------EKDGGDGNGEPKGDGKEKG---EESKEEKEA 246
            .      |.:  |..:..:|              :|...||...|: :.|||.   |..:||.:|
  Fly   192 HPFDALREHL--DGTEVTSKVPWLLVLHKYLNVWQKQQADGTQTPR-NYKEKNQLKETIREEMKA 253

  Fly   247 KEDTANGNIMRINTRQWAKDCNYDAG---KLFNKFFNED-ITYLLRMSNL-WKTRKA-------- 298
            .|:.....|..:||.       :.||   |.....|.:| ...|.:.||: |...||
  Fly   254 DEENYEEAIKAVNTA-------FGAGQVPKSLKAIFEDDACEQLNKKSNVFWIMAKALKHFVIHE 311

  Fly   299 -----PVPVQWDTLLPEGSSGDQKDVAKQH-HKVWSIEECAQVF---ANSLKELSANFLKLEGDD 354
                 |:|    .:||:.::.....:|.|| ::..::::..||:   ...||:|:
  Fly   312 NEGHLPLP----GVLPDMTANTDSYIALQHIYRQQALQDADQVYHKCQEYLKQLA---------- 362

  Fly   355 TLAWDKDDQPAMDFV----AACANVRSHIF--DIERKSRF----EIKSMAGNIIPAIATTNAITA 409
             |..|..|:.::..:    |..|.:|....  :.|:.||.    |...:.||          :||
  Fly   363 -LPADSIDERSVRLICKEAAGLAVIRGTRIAEEYEKSSRLLPLVEDNELQGN----------LTA 416

  Fly   410 GISVMRAFK-------------VLEAKWEQCKAVYARLRPNARNHFLVPD-----------ASLP 450
            ....:||::             ::|....:.|::.|::..:...|..:.|           |.|.
  Fly   417 YNFALRAYERFLSECGNIPGECIVEQDIGRLKSIAAKMLSDLGMHATISDDVLHEICRYGGAELH 481

  Fly   451 GPNPNCHVCASDPAITLKIDTKRMR 475
            ..:.....||:...|  ||.||:.:
  Fly   482 AVSAFIGGCAAQEVI--KIITKQYK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba2	NP_524756.2	ThiF	7..>177	CDD:279270	43/166 (26%)
		Uba2_SUMO	21..459	CDD:238766	117/520 (23%)
		UAE_UbL	467..552	CDD:291402	4/9 (44%)
		UBA2_C	573..691	CDD:292812
APP-BP1	NP_001261699.1	APPBP1_RUB	16..522	CDD:238770	126/545 (23%)
APP-BP1	NP_001261699.1	ThiF	17..>171	CDD:223552	43/166 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446856
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10953
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840