DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uba2 and ula-1

DIOPT Version :9

Sequence 1:	NP_524756.2	Gene:	Uba2 / 44496	FlyBaseID:	FBgn0029113	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001348740.1	Gene:	ula-1 / 266650	WormBaseID:	WBGene00006735	Length:	543	Species:	Caenorhabditis elegans

Alignment Length:	554	Identity:	98/554 - (17%)
Similarity:	182/554 - (32%)	Gaps:	161/554 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 QELVKKSKVLVVGAGGIGCEVLKNLVLSGFTDIEIIDLDTIDLSNLNRQFLFHREHVGKSKARVA 78
            |..:..:...|:|:..:..|:||:|||:|.....::|...::.:::.:.|..|.:.:|:|:|...
Worm    22 QASIGSTSACVLGSDSLATEILKSLVLAGVQSFYVVDDAKVEQADIGQNFFLHADDIGRSRAEAT 86

  Fly    79 RESALSFNPDAKITAYHDSVTSTDY-GVNFFKKFDLVLSALDNRAARNHVNRMCLNADVPLIESG 142
            .|.....||....:|.....|:... .|.....|.:|::|..|........::..|..||.|...
Worm    87 LEKLTELNPSVSGSASSQPPTALAMEDVEKLTTFSVVVAANQNEEIDTTFAKVLYNIRVPFICIK 151

  Fly   143 TAGYNGQVELI--KRGLTQCYECTPK-DKQRSFPGC-----------------TIRNTPSEPIHC 187
            |.|..|.:.:.  :..:...:|..|: |.:...|..                 .:|:||    :.
Worm   152 TFGLIGTIRICIKEHTIANSHEENPRPDLRLDAPFSKLIEMINETNLDEMTLEQLRHTP----YI 212

  Fly   188 IVWAKHLFNQLFGESLEDEDISPDAADPDAKEKDGGDGNGEPKGDGKE----------KGEESKE 242
            ::..|.|  ::|.:...|.:..|...                 .:.||          ..|||..
Worm   213 LLHFKAL--EVFRKQRNDPEAFPSTT-----------------AERKELQAILMSFRRSSEESGT 258

  Fly   243 EKEAKEDTANGNIMR-----------------------INTRQWAKDCNYDAGKLFNKFFNEDIT 284
            :.....|.|...::|                       .:||.:...|     :...:|..|:
Worm   259 KDSENFDEAKAAVIRAFQRTTFQIGSSVKSILSSPQCSTSTRPFWLIC-----EALRRFVTEN-- 316

  Fly   285 YLLRMSNLWKTRKAPVPVQWD--------TLLPEGSSGDQKDVAKQHHKVWSIEECAQVFANSL- 340
                 :||...|.....:..|        ||..|.:..|.::|.:...:|........|.::.:
Worm   317 -----NNLLPLRGTLPDMTSDSSRYTRLATLFHEKALSDAQEVLRLTREVEKERGVGDVISDDVC 376

  Fly   341 ----KELSANFLKLEGDDTLAWDKDDQPAMDFVAACANVRSHIFDIERKSRFEIKSMAGNIIPAI 401
                |  :|:.::::..|.|.::::.:      |....:|....|.|.:::
Worm   377 YRFCK--NADRIRVQYGDVLDYNEETK------AIVEKIRESNIDEETRNQ-------------- 419

  Fly   402 ATTNAITAGISVMRAFKVLEAKWEQCKAVYARLRPNARNHFLVPDASLPGPNPNCHVCASDPAIT 466
                            ||.||.|        .|...|...|.......||.|          .:.
Worm   420 ----------------KVDEATW--------MLLMRAVGRFQKEKGRYPGTN----------GVP 450

  Fly   467 LKIDTKRMRIKELRDEVLVKTLNMLNPDVTVQSN 500
            :.||.:.::   .|.|||::.......|.|..||
Worm   451 VSIDAQDLK---KRVEVLIREALKDEQDFTSISN 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba2	NP_524756.2	ThiF	7..>177	CDD:279270	37/183 (20%)
		Uba2_SUMO	21..459	CDD:238766	87/504 (17%)
		UAE_UbL	467..552	CDD:291402	10/34 (29%)
		UBA2_C	573..691	CDD:292812
ula-1	NP_001348740.1	APPBP1_RUB	8..541	CDD:238770	98/554 (18%)
ula-1	NP_001348740.1	E1_enzyme_family	<443..541	CDD:304554	13/52 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810