Protein Alignment Uba2 and Nae1

DIOPT Version :9

• Sequence 1: NP_524756.2
• Gene: Uba2 / 44496
• FlyBaseID: FBgn0029113
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_659180.1
• Gene: Nae1 / 234664
• MGIID: 2384561
• Length: 534
• Species: Mus musculus
• Alignment Length: 591
• Identity: 121/591 - (20%)
• Similarity: 204/591 - (34%)
• Gaps: 179/591 - (30%)

  Fly    14 QELVKKSKVLVVGAGGIGCEVLKNLVLSGFTDIEIIDLDTIDLSNLNRQFLFHREHVGKSKARVA 78
            ||.::.:.|.::.|...|.|:||||||.|.....|||.:.:...:....|...:..:||::|:.|
Mouse    25 QEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNLVSGEDAGNNFFLQKSSIGKNRAQAA 89

  Fly    79 RESALSFNPDAKITAYHDSVTS-TDYGVNFFKKFDLVLSA--LDNRAARNHVNRMCLNADVPLIE 140
            .|.....|.|...:...:|..: .|...:||.:|.:|::.  |::...|  :..:..|:.:||:.
Mouse    90 MEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTIVVATQLLESTLLR--LADVLWNSQIPLLI 152

  Fly   141 SGTAGYNGQVELIKRGLTQCYECTPKDKQRSFPGCTIRNTPSEPIHCIVWAKHLFNQLFGESLED 205
            ..|.|..|.:.:|                       |:..|       |...|..|.|
Mouse   153 CRTYGLVGYMRII-----------------------IKEHP-------VIESHPDNAL------- 180

  Fly   206 EDISPDAADPDAKEKDGGDGNGEPKGDGKEKGEESKEEKEAKEDTANGNIMRINTRQWAKDCNYD 270
            ||:..|...|:.:|.             .:..:....||:....|....|:.....||..:.|..
Mouse   181 EDLRLDKPFPELREH-------------LQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYNETNGR 232

  Fly   271 AGKLFNKFFNEDITYLLRMSNLWKTRKAPVPVQ-------------WDTLLP---EGSSGDQK-- 317
            ..|.:.:  .||...|:|...|.....||...:             ..|.:|   |....|.:
Mouse   233 IPKSYKE--KEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCI 295

  Fly   318 DVAKQHHKVWSIEECAQVFANSLKELSANFLKLEGDDTLAWDKDDQPAMDFVAACANVRSHIFDI 382
            ::.||....|       :.|.:|||    |:..||...|.                 ||..|.|:
Mouse   296 NITKQTPTFW-------ILARALKE----FVAKEGQGNLP-----------------VRGTIPDM 332

  Fly   383 ERKSRFEIKSMAGNIIPAIATTNAITAGISVMRAFKVLEAKWEQCKAVYARLRPNARNHFLVPDA 447
            ...|...||..  |:....|..:|...|..|.   |:|::..:..:::..:            :.
Mouse   333 IADSNKYIKLQ--NVYREKAKKDAAAVGNHVA---KLLQSVGQAPESISEK------------EL 380

  Fly   448 SLPGPNPNCHVCASDPAITLKIDTKRMRIKELRDEVLVKTLN-------MLNPDVTVQSNGSIL- 504
            .|        :|::...:.:      :|.:.|.:|..:.|:|       |.|||     |..:|
Mouse   381 KL--------LCSNSAFLRV------VRCRSLAEEYGLDTVNKDEIISSMDNPD-----NEIVLY 426

  Fly   505 --------ISSEEG--------ETECNDGKLLSELNIVDGVILKCDDFFQNYELSIIISHFDAER 553
                    ...:.|        :.|.:.|||.|.|.          .|.|.|.||:::      :
Mouse   427 LMLRAVDRFHKQHGRYPGVSNYQVEEDIGKLKSCLT----------GFLQEYGLSVMV------K 475

  Fly   554 DENLFE 559
            |:.:.|
Mouse   476 DDYVHE 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uba2	NP_524756.2	ThiF	7..>177	CDD:279270	39/165 (24%)
		Uba2_SUMO	21..459	CDD:238766	93/458 (20%)
		UAE_UbL	467..552	CDD:291402	23/108 (21%)
		UBA2_C	573..691	CDD:292812
Nae1	NP_659180.1	ThiF	9..>193	CDD:223552	49/206 (24%)
		APPBP1_RUB	11..532	CDD:238770	121/591 (20%)
		Interaction with UBA3. /evidence=ECO:0000250	331..344		4/14 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900