DRSC/TRiP Functional Genomics Resources

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Protein Alignment Uba2 and Uba3

DIOPT Version :10

Sequence 1:NP_524756.2 Gene:Uba2 / 44496 FlyBaseID:FBgn0029113 Length:700 Species:Drosophila melanogaster
Sequence 2:NP_035796.2 Gene:Uba3 / 22200 MGIID:1341217 Length:462 Species:Mus musculus


Alignment Length:571 Identity:143/571 - (25%)
Similarity:208/571 - (36%) Gaps:222/571 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 FPP---TLQELVKKSKVLVVGAGGIGCEVLKNLVLSGFTDIEIIDLDTIDLSNLNRQFLFHREHV 70
            |.|   :||.|:...||||:||||:|||:||||.||||..|.:||:||||:|||||||||..:.|
Mouse    56 FEPSTESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDV 120

  Fly    71 GKSKARVARESALSFNPDAKITAYHDSVTSTDYGVNFFKKFDLVLSALDNRAARNHVNRMCL--- 132
            |:.||.||.|......|:..:..:.:.:  .|:...|:::|.:::..||:..||..:|.|.:   
Mouse   121 GRPKAEVAAEFLNDRVPNCNVVPHFNKI--QDFNDTFYRQFHIIVCGLDSIIARRWINGMLISLL 183

  Fly   133 ---------NADVPLIESGTAGYNGQVELIKRGLTQCYECTPK--DKQRSFPGCTIRNTPSEPIH 186
                     ::.||||:.||.|:.|...:|..|:|.|.|||.:  ..|.:||.|||.:.|..|.|
Mouse   184 NYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIASMPRLPEH 248

  Fly   187 CIVWAKHLFNQLFGESLEDEDISPDAADPDAKEKDGGDGNGEPKGDGKEKGEESKEEKEAKEDTA 251
            ||.:.:.|                                                         
Mouse   249 CIEYVRML--------------------------------------------------------- 256

  Fly   252 NGNIMRINTRQWAKDCNYDAGKLFNKFFNEDITYLLRMSNLWKTRKAPVPVQWDTLLPEGSSGDQ 316
                      ||.|:..:..|                           ||:..|.  ||      
Mouse   257 ----------QWPKEQPFGDG---------------------------VPLDGDD--PE------ 276

  Fly   317 KDVAKQHHKVWSIEECAQVFANSLKELSANFLKLEGDDTLAWDKDDQPAMDFVAACANVRSHIFD 381
                   |..|       :|..|                                          
Mouse   277 -------HIQW-------IFQKS------------------------------------------ 285

  Fly   382 IERKSRFEIK--------SMAGNIIPAIATTNAITAGISVMRAFKVLEAKWEQCKAVYARLRPNA 438
            |||.|::.|:        .:...||||:|:|||:.|.:.....||:       ..:.|..|    
Mouse   286 IERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFKI-------ATSAYIPL---- 339

  Fly   439 RNHFLVPDASLPG---------PNPNCHVCASDPA-ITLKIDTKRMRI---------KELRDEVL 484
             |::||.: .:.|         ...||..|:..|. |......|...:         .:::...:
Mouse   340 -NNYLVFN-DVDGLYTYTFEAERKENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAI 402

  Fly   485 VKTLNMLNPDVTVQSNGSILISSEEGETECNDGKLLSELNIVDGVILKCDD 535
            ..||...|..:.:||     ::|.|..|..|..|.|.||.:|||..|...|
Mouse   403 TATLEGKNRTLYLQS-----VTSIEERTRPNLSKTLKELGLVDGQELAVAD 448

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Uba2NP_524756.2 Uba2_SUMO 21..459 CDD:238766 116/468 (25%)
UAE_UbL 467..552 CDD:464286 19/78 (24%)
Uba3NP_035796.2 Interaction with UBE2M N-terminus. /evidence=ECO:0000250 53..70 5/13 (38%)
Uba3_RUB 71..368 CDD:238765 116/469 (25%)
Interaction with UBE2M N-terminus. /evidence=ECO:0000250 157..161 1/3 (33%)
Interaction with UBE2M N-terminus. /evidence=ECO:0000250 192..217 9/24 (38%)
Interaction with NEDD8. /evidence=ECO:0000250 227..229 0/1 (0%)
Interaction with NAE1. /evidence=ECO:0000250 242..248 2/5 (40%)
Interaction with NAE1. /evidence=ECO:0000250 292..295 0/2 (0%)
Interaction with UBE2M N-terminus. /evidence=ECO:0000250 331..338 1/13 (8%)
Interaction with NEDD8. /evidence=ECO:0000250 352..357 0/4 (0%)
Interaction with UBE2M core domain. /evidence=ECO:0000250 368..462 21/86 (24%)
E2_bind 376..461 CDD:462611 19/78 (24%)

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