Protein Alignment Uba2 and UBA2

DIOPT Version :10

• Sequence 1: NP_524756.2
• Gene: Uba2 / 44496
• FlyBaseID: FBgn0029113
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_005490.1
• Gene: UBA2 / 10054
• HGNCID: 30661
• Length: 640
• Species: Homo sapiens
• Alignment Length: 712
• Identity: 336/712 - (47%)
• Similarity: 449/712 - (63%)
• Gaps: 88/712 - (12%)

  Fly     4 AINGVFPPTLQELVKKSKVLVVGAGGIGCEVLKNLVLSGFTDIEIIDLDTIDLSNLNRQFLFHRE 68
            |::...|..|.|.|...:||||||||||||:||||||:||:.|::|||||||:|||||||||.::
Human     2 ALSRGLPRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKK 66

  Fly    69 HVGKSKARVARESALSFNPDAKITAYHDSVTSTDYGVNFFKKFDLVLSALDNRAARNHVNRMCLN 133
            |||:|||:||:||.|.|.|.|.|.|||||:.:.||.|.||::|.||::||||||||||||||||.
Human    67 HVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRMCLA 131

  Fly   134 ADVPLIESGTAGYNGQVELIKRGLTQCYECTPKDKQRSFPGCTIRNTPSEPIHCIVWAKHLFNQL 198
            |||||||||||||.|||..||:|:|:||||.||..||:|||||||||||||||||||||:|||||
Human   132 ADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPSEPIHCIVWAKYLFNQL 196

  Fly   199 FGESLEDEDISPDAADPDAKEKDGGDGNGEPKGDGKEKGEESKEEKEAKEDTANGNIMRINTRQW 263
            |||...|:::|||.|||:|                  ..|.::.|..|:....:|:|.||:|::|
Human   197 FGEEDADQEVSPDRADPEA------------------AWEPTEAEARARASNEDGDIKRISTKEW 243

  Fly   264 AKDCNYDAGKLFNKFFNEDITYLLRMSNLWKTRKAPVPVQWDTLLPEG---SSGDQKD---VAKQ 322
            ||...||..|||.|.|.:||.|||.|..||:.||.|||:.|..:..:|   ::.||::   :..:
Human   244 AKSTGYDPVKLFTKLFKDDIRYLLTMDKLWRKRKPPVPLDWAEVQSQGEETNASDQQNEPQLGLK 308

  Fly   323 HHKVWSIEECAQVFANSLKELSANFLKLEGDDT-LAWDKDDQPAMDFVAACANVRSHIFDIERKS 386
            ..:|..::..|::|:.|::.|..: |..:||.. |.|||||..|||||.:.||:|.|||.:..||
Human   309 DQQVLDVKSYARLFSKSIETLRVH-LAEKGDGAELIWDKDDPSAMDFVTSAANLRMHIFSMNMKS 372

  Fly   387 RFEIKSMAGNIIPAIATTNAITAGISVMRAFKVLEAKWEQCKAVYARLRPNARNHFLVPDASLPG 451
            ||:|||||||||||||||||:.||:.|:...|:|..|.:||:.::...:||.|...||| .:|..
Human   373 RFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNKQPNPRKKLLVP-CALDP 436

  Fly   452 PNPNCHVCASDPAITLKIDTKRMRIKELRDEVLVKTLNMLNPDVTVQ-SNGSILISSEEGETECN 515
            |||||:||||.|.:|::::..::.:..|:|:::.:...|:.|||.:: ..|:|||||||||||.|
Human   437 PNPNCYVCASKPEVTVRLNVHKVTVLTLQDKIVKEKFAMVAPDVQIEDGKGTILISSEEGETEAN 501

  Fly   516 DGKLLSELNIVDGVILKCDDFFQNYELSIIISHFDAERDENLFEVVADASQLKPKDEDQKEAVKD 580
            :.|.|||..|.:|..|:.|||.|:|.|.|.|.|.:....:..||||.||        .:|...|.
Human   502 NHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGKDVEFEVVGDA--------PEKVGPKQ 558

  Fly   581 KEDEPKSAKKRSTNGEGDSKDDG--PSTSKRSRPNEVVEEDDDDCLVIEEDED----QADVVVVA 639
            .||..||.    |||    .|||  ||||        ..::.||.|:::.||:    .|||
Human   559 AEDAAKSI----TNG----SDDGAQPSTS--------TAQEQDDVLIVDSDEEDSSNNADV---- 603

  Fly   640 TDKLSVQSPPKSGSKRKPCEVIEDEDITEILESSDDEPAGPTKCKRSRLDDSNPV-AVISID 700
                   |..:...|||   :.|.|:::               .||||::....: .||::|
Human   604 -------SEEERSRKRK---LDEKENLS---------------AKRSRIEQKEELDDVIALD 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uba2	NP_524756.2	Uba2_SUMO	21..459	CDD:238766	247/444 (56%)
		UAE_UbL	467..552	CDD:464286	35/85 (41%)
UBA2	NP_005490.1	Uba2_SUMO	19..444	CDD:238766	247/444 (56%)
		UBA_E1_SCCH	179..362	CDD:463157	84/201 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	202..231		11/46 (24%)
		UAE_UbL	452..538	CDD:464286	35/85 (41%)
		UBA2_C	549..635	CDD:465058	36/138 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	551..640		36/133 (27%)