DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uba2 and uba7

DIOPT Version :9

Sequence 1:	NP_524756.2	Gene:	Uba2 / 44496	FlyBaseID:	FBgn0029113	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_005155933.1	Gene:	uba7 / 100001302	ZFINID:	ZDB-GENE-121120-4	Length:	1016	Species:	Danio rerio

Alignment Length:	702	Identity:	168/702 - (23%)
Similarity:	276/702 - (39%)	Gaps:	191/702 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VFPPTLQELVKKSKVLVVGAGGIGCEVLKNLVLSGF-----TDIEIIDLDTIDLSNLNRQFLFHR 67
            ||....|..:||.|..:||||.||||:|||..|.|.     ..|.:.|:|:|:.|||||||||..
Zfish   415 VFGSDFQNKLKKQKYFLVGAGAIGCELLKNFALIGLGAGEGGSITVTDMDSIERSNLNRQFLFRS 479

  Fly    68 EHVGKSKARVARESALSFNPDAKITAYHDSV---TSTDYGVNFFKKFDLVLSALDNRAARNHVNR 129
            :.:|:.|:..|.|:....||...|.|..:.|   |...|..:|:...|.|.:||||..||.::::
Zfish   480 QDIGRPKSEAAAEAVKEMNPFMNIIAQQNRVCAETEEVYTHSFYTGLDGVAAALDNVDARVYLDQ 544

  Fly   130 MCLNADVPLIESGTAGYNGQVELIKRGLTQCYECTPKDKQRSFPGCTIRNTPSEPIHCIVWAKHL 194
            .|:....|::|.||.|..|...::...||:.|..:....|::.|.||::|.|....|.:.||:..
Zfish   545 CCVRNKKPMLEGGTLGSKGHTMVVVPRLTESYGLSSSGGQKAIPICTLKNFPHRIEHTLQWARDH 609

  Fly   195 FNQLFGESLEDEDISPDAADPDAKEKDGGDGNGEPKGDGKEKGEESKEEKEAKEDTANGNIMRIN 259
            |..||.::.  ::::...:||...::....|:           .|:.|..|        .:.|..
Zfish   610 FEGLFKQTA--QNVNNFLSDPGFVDRTVARGD-----------VEAVEMLE--------GVYRSL 653

  Fly   260 TRQWA---KDCNYDAGKLFNKFFNEDITYLLR--------MSNL--WK-TRKAPVPVQWDT---- 306
            :..|.   |||...|.:.:...:|..|..||.        .|.|  |. .::.|..:.:||
Zfish   654 SDDWPENWKDCISWARRQWETLYNNHIRQLLHCFPPDQLTSSGLPFWMGAKRCPHALTFDTNNAT 718

  Fly   307 --------------------------------------LLPEGS---------SGDQKDVAKQHH 324
                                                  ..|:.|         ..::.:..|:..
Zfish   719 HMDFIIAAANLYAQIFGITGSRNRADIQTVLQGVKVPEFTPKSSVKIAVTDQQLNEENEERKEED 783

  Fly   325 KV--WSIEECAQVFANSLKELSANFLKLEGDDTLAWDKDDQP--AMDFVAACANVRSHIFDIERK 385
            ||  ..::|  |:....|::.|   .::...|   ::|||..  .||::.|.:|:|:..:||...
Zfish   784 KVKLGMLKE--QLSKLQLRDRS---FRMHPQD---FEKDDDSNFHMDYIVAASNLRAENYDIPTA 840

  Fly   386 SRFEIKSMAGNIIPAIATTNAITAGISVMRAFKVLE--AKWEQCKAVYARLRPNARNHFLVPDAS 448
            .|.:.|.:||.||||||||.|..||:..:..:|:::  :|....:..|..|   |..:|:.   |
Zfish   841 DRHKSKLIAGRIIPAIATTTAAIAGLMCLELYKLVQGHSKITSYRNAYINL---ATQYFVF---S 899

  Fly   449 LPGPNPNCHVCASDPAITLKIDTKRMRIKELRDEVLVKTLNMLNPDVTVQSNGSILISSEEGETE 513
            .|.|.|           |..:..:|..:.:               |..||       ...||:.|
Zfish   900 QPCPAP-----------TFTVAGQRYSLWD---------------DFPVQ-------GCREGQEE 931

  Fly   514 CNDGKLLSELNIVDGVILKCDDFFQNYELSIIISHFDAERDENLFEVVADASQLKPKDE--DQKE 576
            ....:||.  :|.:...||....:  |..:::.|......|..... ::|..:|..|.|  |.::
Zfish   932 MTLEELLK--HIEEEHKLKISGLY--YGPAVLYSDLSNHSDRMKLS-ISDLVRLATKHEVADHQQ 991

  Fly   577 AVKDKEDEPKSAKKRSTNGEGDSKDDGPSTSKRSRPNEVVE--EDDDDCLVI 626
            .:                                   |::.  |:|:|||.:
Zfish   992 ML-----------------------------------EIIPSFEEDEDCLTV 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba2	NP_524756.2	ThiF	7..>177	CDD:279270	65/176 (37%)
		Uba2_SUMO	21..459	CDD:238766	136/516 (26%)
		UAE_UbL	467..552	CDD:291402	14/84 (17%)
		UBA2_C	573..691	CDD:292812	7/56 (13%)
uba7	XP_005155933.1	Ube1	5..1013	CDD:273603	168/702 (24%)
		Ube1_repeat1	10..393	CDD:238768
		E1_4HB	258..326	CDD:292809
		E1_enzyme_family	428..970	CDD:304554	152/613 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910