DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and GLR3.4

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_001030971.1	Gene:	GLR3.4 / 839268	AraportID:	AT1G05200	Length:	959	Species:	Arabidopsis thaliana

Alignment Length:	1072	Identity:	231/1072 - (21%)
Similarity:	385/1072 - (35%)	Gaps:	337/1072 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SGVGVSAQPSLTEKIPLGAIFEQGTDEV---QSAFKYAMLN---HNLNVSSRRFELQAYVDVINT 86
            |.:|.:|:|::          :...|:|   ||..|...||   .:.|.|.          .|.|
plant    71 SFIGRAAKPAV----------KAAMDDVNADQSVLKGIKLNIIFQDSNCSG----------FIGT 115

  Fly    87 ADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLH--SY-SNTFQMPFVTPWFPEKVLTPSSGFLD 148
            ..|.:|..          ..::.|:.|.|....|  || :|...:|.::....:..|: |..|..
plant   116 MGALQLME----------NKVVAAIGPQSSGIAHMISYVANELHVPLLSFGATDPTLS-SLQFPY 169

  Fly   149 FALSMRPDYHQ--AIIDTIQFYGWRKIIYLY----DSHDGLLRLQQI---------YQ-GLRPGN 197
            |..:.:.||.|  ||.|.:.:.|||::|.::    ...:|:..|..:         |: .:.||.
plant   170 FLRTTQNDYFQMHAIADFLSYSGWRQVIAIFVDDECGRNGISVLGDVLAKKRSRISYKAAITPGA 234

  Fly   198 ESFQV-ELVKRISNVSMAIEFLH-----------TLEQIGRFENKHIVLD---CPTEMAKQILIQ 247
            :|..: :|:..::.:...:..:|           ..:.:|...:.::.:.   .||.|..   ::
plant   235 DSSSIRDLLVSVNLMESRVFVVHVNPDSGLNVFSVAKSLGMMASGYVWIATDWLPTAMDS---ME 296

  Fly   248 HVRDLRLGRRTYHYLLSGLVMDDRWESEIIEFGAINITGFRIVDTNRRLVREFYDSWKRLDPQMS 312
            ||....:.      ||.|:|                  .||.......:.|:|...||.|.|
plant   297 HVDSDTMD------LLQGVV------------------AFRHYTIESSVKRQFMARWKNLRP--- 334

  Fly   313 VGAGRESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYS 377
                .:..::.|...||:|:::..|.:...|:     .||:               |.|:..|..
plant   335 ----NDGFNSYAMYAYDSVWLVARALDVFFRE-----NNNI---------------TFSNDPNLH 375

  Fly   378 ASGGGGGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDI 442
            .:.|......|                            ::.:..|:|..:.:..:...|:||.|
plant   376 KTNGSTIQLSA----------------------------LSVFNEGEKFMKIILGMNHTGVTGPI 412

  Fly   443 KFNDDGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLE 507
            :|:.|..|||....|:.:. .:|...|..|::.:||..::.:.:..||......|:
plant   413 QFDSDRNRVNPAYEVLNLE-GTAPRTVGYWSNHSGLSVVHPETLYSRPPNTSTANQ--------- 467

  Fly   508 EPYIMLKQVAF-GE-----------------KLHGNNR---------------FEGYCKDL---- 535
                .||.:.: ||                 ::...||               ..|||.|:
plant   468 ----RLKGIIYPGEVTKPPRGWVFPNNGKPLRIGVPNRVSYTDYVSKDKNPPGVRGYCIDVFEAA 528

  Fly   536 ADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITAERERVIDFS 600
            .:||...:...|.|       ||..|.:.  .:|.:|.|:|....|:|:..:||...|.|.:||:
plant   529 IELLPYPVPRTYIL-------YGDGKRNP--SYDNLVNEVVADNFDVAVGDITIVTNRTRYVDFT 584

  Fly   601 KPFMSLGISIMIK-KPVKQTPGVFSFMNPLSQEIWVSV--IFSYIGVSIVLFFVSRFSPHEWRLV 662
            :||:..|:.::.. |..|.:|  :||:.|.:.|:|...  .|.::| ::|.....||: .|:|
plant   585 QPFIESGLVVVAPVKEAKSSP--WSFLKPFTIEMWAVTGGFFLFVG-AMVWILEHRFN-QEFR-- 643

  Fly   663 QQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSG 727
                                                 |||.....|.
plant   644 -------------------------------------GPPRRQLITI------------------ 653

  Fly   728 GSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTANLAAFLTV 792
                           ||||.:.......:.:..|: ||.....|.|..||:.|||||:|.:.||:
plant   654 ---------------FWFSFSTMFFSHRENTVSSL-GRFVLIIWLFVVLIINSSYTASLTSILTI 702

  Fly   793 ERMVTPINSPEDLAMQTE---VQYGTLLHGSTWDFFRRSQIGLHNKMWEYMNSRKHVFVPTYDE- 853
            .::.:.|...:.|....|   ||.||         |.|      |.:...:|......||..||
plant   703 RQLTSRIEGIDSLVTSNEPIGVQDGT---------FAR------NYLINELNILPSRIVPLKDEE 752

  Fly   854 ----GIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGIATPLGSALKDPINLA 914
                .::|..|:.|..|::.|.|..|.:.....|....||:.....|:|.|....|.|...::.|
plant   753 QYLSALQRGPNAGGVAAIVDELPYIEVLLTNSNCKFRTVGQEFTRTGWGFAFQRDSPLAVDMSTA 817

  Fly   915 VLTLKENGELIKLRNKWWYEKAECSTHKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILEYC 979
            :|.|.|.|||.|:..||...|.|||. :...:..|:|||.:..|:|  ||.|  ::.|:|:..:.
plant   818 ILQLSEEGELEKIHRKWLNYKHECSM-QISNSEDSQLSLKSFWGLF--LICG--ITCFMALTVFF 877

  Fly   980 FR-----------SRDSRSAS-----SGSGMG 995
            :|           |.|...|.     |.||.|
plant   878 WRVFWQYQRLLPESADEERAGEVSEPSRSGRG 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	89/474 (19%)
		ANF_receptor	55..461	CDD:279440	85/445 (19%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	112/488 (23%)
		Lig_chan	632..967	CDD:278489	84/344 (24%)
GLR3.4	NP_001030971.1	PBP1_GABAb_receptor_plant	62..450	CDD:380645	95/492 (19%)
		Periplasmic_Binding_Protein_Type_2	<518..591	CDD:389745	25/81 (31%)
		Lig_chan	615..869	CDD:365843	85/348 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	169	1.000	Inparanoid score	I1556
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.870