DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and GLR2.1

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_198062.2	Gene:	GLR2.1 / 832768	AraportID:	AT5G27100	Length:	901	Species:	Arabidopsis thaliana

Alignment Length:	1091	Identity:	214/1091 - (19%)
Similarity:	375/1091 - (34%)	Gaps:	359/1091 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 AQPSLTEKIPLGAIFEQGTDEVQSAFKYAMLNHNLNVS---SRRFELQAYV---------DVINT 86
            ||..:| .:.:|.:.:.||    :.....:|..|:::|   |...|.|..:         ||: |
plant    25 AQNRIT-NVNVGIVNDIGT----AYSNMTLLCINMSLSDFYSSHPETQTRLVTTVVDSKNDVV-T 83

  Fly    87 ADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLTPSSGFLDFAL 151
            |.|..|. ||.|   :.|.::||..:......:.......|:|.||    ....:||...:....
plant    84 AAAAALD-LITN---KEVKAILGPWTSMQAQFMIEMGQKSQVPIVT----YSATSPSLASIRSQY 140

  Fly   152 SMRPDYH-----QAIIDTIQFYGWRKI--IYLYDSH-DGLL-RLQQIYQGLR---PGNESFQVEL 204
            ..|..|.     .||.:.|:.:|||::  :|:.|:. :|:: ||..:.|.:.   |    ::..:
plant   141 FFRATYDDSSQVHAIKEIIKLFGWREVAPVYVDDTFGEGIMPRLTDVLQEINVRIP----YRTVI 201

  Fly   205 VKRISNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRTYHYLLSGLVMD 269
            ....::..:::|.|..:....|....|:|     |:..........::.|.::.|.::|:..:.|
plant   202 SPNATDDEISVELLRMMTLPTRVFVVHLV-----ELLASRFFAKATEIGLMKQGYVWILTNTITD 261

  Fly   270 -----DRWESEIIEFGAINITGFRIVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYD 329
                 :..|.|.::    .:.|.:......:.:..|...|.:..|       ...::......||
plant   262 VLSIMNETEIETMQ----GVLGVKTYVPRSKELENFRSRWTKRFP-------ISDLNVYGLWAYD 315

  Fly   330 AVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAG 394
            |...|                        .|.:.:|..|..:                    |..
plant   316 ATTAL------------------------ALAIEEAGTSNLT--------------------FVK 336

  Fly   395 SDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKF--------------- 444
            .|       |.|  :.:..:| :...::|.|:.:.|.:|..:||.||.:|
plant   337 MD-------AKR--NVSELQG-LGVSQYGPKLLQTLSRVRFQGLAGDFQFINGELQPSVFEIVNV 391

  Fly   445 -NDDGRRVNYTLHVVEMTVN-----SAMVKVAEWNDDAGLQPLNAKYVRLRPHV----------- 492
             ...||.:.:.:....:..|     ::....:.|.|            ||||.:
plant   392 NGQGGRTIGFWMKEYGLFKNVDQKPASKTTFSSWQD------------RLRPIIWPGDTTSVPKG 444

  Fly   493 -EFEKNRTYIVTTVLEEPYIMLKQVAFGEKLHGNNRFEGYCKDLAD------------------- 537
             |...|.               |::..|..:  ||.|:.:.|...|
plant   445 WEIPTNG---------------KRLQIGVPV--NNTFQQFVKATRDPITNSTIFSGFSIDYFEAV 492

  Fly   538 LLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKP 602
            :.|....|:|:....:|           ||:|.:|.::...:.|..:|..||::.|...:|||.|
plant   493 IQAIPYDISYDFIPFQD-----------GGYDALVYQVYLGKYDAVVADTTISSNRSMYVDFSLP 546

  Fly   603 FMSLGISIMIKKPVKQTPGVFS--FMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQ 665
            :...|:.:::  |||.:....|  |:.||:..:|:..:.|:..:.:|:          |.|
plant   547 YTPSGVGLVV--PVKDSVRRSSTIFLMPLTLALWLISLLSFFIIGLVV----------WVL---- 595

  Fly   666 PQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSS 730
             :...:||                                               ...||
plant   596 -EHRVNPD-----------------------------------------------FDGPG----- 607

  Fly   731 SAVVNEFSVWNSFWFSLAAFMQQGCDLSPR----SVSGRIAAASWFFFTLILISSYTANLAAFLT 791
                 ::.:...||||.:..:     .:||    |...|:....|:|..|:|..||||:||:.||
plant   608 -----QYQLSTIFWFSFSIMV-----FAPRERVLSFWARVVVIIWYFLVLVLTQSYTASLASLLT 662

  Fly   792 VERM---VTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYMNSRKHVFVPTYDE 853
            .:.:   ||.|||.  ||....|.|     .|::...|....|..........|.:|.     |.
plant   663 TQHLHPTVTNINSL--LAKGESVGY-----QSSFILGRLRDSGFSEASLVSYGSPEHC-----DA 715

  Fly   854 GIKRVRNSKGKYALLVESPKNEYVN--AREPCDTMK-VGRNLDTKGFGIATPLGSALKDPINLAV 915
            .:.:.:...|..|:|:|.|   ||.  ..:.|:..| |.......|.|...|:||.|...|:.|:
plant   716 LLSKGQAEGGVSAVLMEVP---YVRIFLGQYCNKYKMVQTPFKVDGLGFVFPIGSPLVADISRAI 777

  Fly   916 LTLKENGELIKLRNKWWYEKAE-CS---THKDGETSHS--ELSLSNVAGIFYILIGGLLVSVFV- 973
            |.::|:.:..:|.|.|:....| |.   |:.|...|.|  :|...:    |::|   .||:..|
plant   778 LKVEESNKANQLENAWFKPIDESCPDPLTNPDPNPSVSFRQLGFDS----FWVL---FLVAAIVC 835

  Fly   974 --AILEYC-------------------FRSRDSRS---------ASSGSGM 994
              |:|::.                   |...|.:|         .|||.||
plant   836 TMALLKFVYQFLKENPNQRNLRVLWEKFNEPDQKSYIKDVTKCQCSSGQGM 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	84/484 (17%)
		ANF_receptor	55..461	CDD:279440	78/450 (17%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	101/472 (21%)
		Lig_chan	632..967	CDD:278489	76/350 (22%)
GLR2.1	NP_198062.2	PBP1_GABAb_receptor	49..411	CDD:107361	78/444 (18%)
		ANF_receptor	49..392	CDD:279440	76/425 (18%)
		GluR_Plant	452..794	CDD:270404	98/448 (22%)
		Periplasmic_Binding_Protein_Type_2	478..>685	CDD:304360	62/298 (21%)
		Lig_chan	576..835	CDD:278489	78/357 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.920