DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and GLR2.4

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_001328410.1	Gene:	GLR2.4 / 829299	AraportID:	AT4G31710	Length:	912	Species:	Arabidopsis thaliana

Alignment Length:	1081	Identity:	213/1081 - (19%)
Similarity:	381/1081 - (35%)	Gaps:	374/1081 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLWLTWSSGGGGGSGVGVSAQPSLTEKIPLGAIFEQGTDEVQSAFKYAMLNHNLNVS---SRRFE 76
            |::|.:..|...|.|     |.:..:.|.:|.:.:.||    :|...::|..|:::|   |.|.|
plant    33 LVFLVFIFGVKLGKG-----QNTTIQVINVGVVTDVGT----TASNLSLLAINMSLSDFYSSRPE 88

  Fly    77 LQAYVDVINTAD--------AFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTP 133
            .:..: ::|.||        |.....||.|   :.|.::||..:......:.......|:|.::
plant    89 SRTRL-LLNFADSRDDVVGAAAAALDLIKN---KEVKAILGPRTTMQASFVIEVGQKSQVPIIS- 148

  Fly   134 WFPEKVLTPSSGFLDFALS---MRPDYH-----QAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIY 190
                  .:.:|.|||...|   .|..|.     |||.:.|:.:|||:::.:|:::       ...
plant   149 ------FSATSPFLDSGRSPYFFRSTYDDSSQVQAISEIIKVFGWREVVPVYENN-------AFG 200

  Fly   191 QGLRPGNESFQVELVKRISNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAK--QILIQHV---- 249
            :|:.||       |...:..:::.|.:...:..  ...:..|.:|....|.|  ::.:.|:
plant   201 EGIMPG-------LTDALQAINIRIPYRTVISP--NATDDEISVDLLKLMTKPTRVFVVHMNRFL 256

  Fly   250 --------RDLRLGRRTYHYLLSG-----LVMDDRWESEIIEFGAINI-TGFRI---VDTNR-RL 296
                    |:..|.::.|.::|:.     ||:.:..:.|.:: |.|.| |.|.|   :.|.| ||
plant   257 ASRVFSKARETGLMKQGYAWILTNGVIDHLVLMNGTDIEAMQ-GVIGIRTHFPISEELQTFRSRL 320

  Fly   297 VREFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLM 361
            .:.|..|               .::......|||...|.                         |
plant   321 AKAFPVS---------------ELNIYGLRAYDATTALA-------------------------M 345

  Fly   362 VAQAAASTS-----SDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWE 421
            ..:.|.:|:     .||.|.|                               |...    ::..|
plant   346 AVEEAGTTNLTFSKMDGRNIS-------------------------------DLEA----LSVSE 375

  Fly   422 HGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQ------- 479
            :|.|:.|.|.:::.:||:||..|.|.  :::.::..:...::...:.|..|..|.||.
plant   376 YGPKLIRSLSQIQFKGLSGDYHFVDG--QLHASVFEIVNVIDGGGILVGFWTQDKGLVKDLSPSS 438

  Fly   480 -------------------------------PLNAKYVRLRPHV----EFEKNRTYIVTTVLEEP 509
                                           |.|.|.:::...|    :|.|     |||
plant   439 GTTRTFSSWKNHLNPILWPGITLTVPKGWEIPTNGKELQIGVPVGTFPQFVK-----VTT----- 493

  Fly   510 YIMLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGE 574
                      :.|.......|:|.|..:.:.:.:..:...|.:.   :|.:        ||...:
plant   494 ----------DPLTHETIVTGFCIDFFEAVIQAMPYDVSHRFIP---FGDD--------DGKTND 537

  Fly   575 LVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFS--FMNPLSQEIWVSV 637
                        .||.|.|...:||:.|:.:.|:.:::  |:|......|  |..||:..:|
plant   538 ------------TTILANRSSYVDFTLPYTTSGVGMVV--PLKDNVARSSLIFFKPLTPGLW--- 585

  Fly   638 IFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPP 702
                 |:::..|||..|.  .|.|                 |...|.:            ..|||
plant   586 -----GMTLGSFFVVGFV--VWIL-----------------EHRVNSE------------FTGPP 614

  Fly   703 TPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPR----SVS 763
                                             ::.:...|||:.:..:     .:||    |.:
plant   615 ---------------------------------QYQISTMFWFAFSIMV-----FAPRERVMSFT 641

  Fly   764 GRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRS 828
            .|:...:|:|..|:|..||||:|::.||.:::     :|.:.:::     ..|..|....:.|.|
plant   642 ARVVVITWYFIVLVLTQSYTASLSSLLTTQQL-----NPTETSIK-----NVLAKGGPVAYQRDS 696

  Fly   829 QIGLHNKMWE--YMNSRKHVFVP-TYDEGIKRVRN---SKGKY-ALLVESPKNEYVNA--REPCD 884
            .:  ..|:.|  :..||   .|| |..|..:.:.|   |||.. |..:|.|   ||..  .:.|.
plant   697 FV--LGKLRESGFPESR---LVPFTSPEKCEELLNKGPSKGGVSAAFMEVP---YVRVFLGQYCK 753

  Fly   885 TMK-VGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWW--YEKAEC-----STH 941
            ..| |....|..|||...|:||.|...::.|:|.:.|:.:..:|...|:  .:|. |     :..
plant   754 KYKMVEVPFDVDGFGFVFPIGSPLVADVSRAILKVAESNKATQLETAWFKNIDKT-CPDPMNNPD 817

  Fly   942 KDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILEY--CF 980
            .:...|..:|||.:    |.:|.........:|:|::  ||
plant   818 PNPTVSFRKLSLDS----FLLLFVAAATVCTLALLKFVICF 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	92/482 (19%)
		ANF_receptor	55..461	CDD:279440	86/453 (19%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	95/458 (21%)
		Lig_chan	632..967	CDD:278489	77/355 (22%)
GLR2.4	NP_001328410.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.920