DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and GLR1.1

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_187061.1	Gene:	GLR1.1 / 819566	AraportID:	AT3G04110	Length:	808	Species:	Arabidopsis thaliana

Alignment Length:	1022	Identity:	189/1022 - (18%)
Similarity:	354/1022 - (34%)	Gaps:	305/1022 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 GVSAQPS---LTEKIPLGAIFEQGTDE---VQSAFKYAMLN-HNLNVSSRR-------------- 74
            ||.|.||   :.|::.:|.:.:..:.:   ::::|..|:.: :.:|...|.
plant    16 GVVAAPSDDDVFEEVRVGLVVDLSSIQGKILETSFNLALSDFYGINNGYRTRVSVLVRDSQGDPI 80

  Fly    75 FELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKV 139
            ..|.|..|::..|.|               .:::||.|......|.:.|...::|.::.:.|..:
plant    81 IALAAATDLLKNAKA---------------EAIVGAQSLQEAKLLATISEKAKVPVISTFLPNTL 130

  Fly   140 -LTPSSGFLDFALSMRPDYHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVE 203
             |.....|:.:......: .:.|...||.:..:.::.:|:..|......||..      |:||.:
plant   131 SLKKYDNFIQWTHDTTSE-AKGITSLIQDFSCKSVVVIYEDADDWSESLQILV------ENFQDK 188

  Fly   204 LVKRISNVSMAIEFL---HTLEQIGRFE--NKHIVLDCPTEMAKQILIQHVRDLRLGRRTYHYLL 263
            .:....:.|.|:...   |.:.|:.:.:  ...:.:...:|:....|.|.|..|.|....:.::|
plant   189 GIYIARSASFAVSSSGENHMMNQLRKLKVSRASVFVVHMSEILVSRLFQCVEKLGLMEEAFAWIL 253

  Fly   264 SGLVMDDRWESEIIEFGAI-----NITGFRIVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQ 323
            :...|:      .:|..||     .:.||:........|:.|   ..||..:|......|..|..
plant   254 TARTMN------YLEHFAITRSMQGVIGFKSYIPVSEEVKNF---TSRLRKRMGDDTETEHSSVI 309

  Fly   324 AAL-MYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGG 387
            ..| .:|...:|..|..|                                   :|.||
plant   310 IGLRAHDIACILANAVEK-----------------------------------FSVSG------- 332

  Fly   388 AGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVN 452
                    ....|..:::..||.                   :|....:||:|||:.:|: :.::
plant   333 --------KVEASSNVSADLLDT-------------------IRHSRFKGLSGDIQISDN-KFIS 369

  Fly   453 YTLHVVEMTVNSAMVKVAEWNDDAGLQ------PLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYI 511
            .|..:|.:. .....::..|:..:..|      |..::.:. |..|..||.          |..:
plant   370 ETFEIVNIG-REKQRRIGLWSGGSFSQRRQIVWPGRSRKIP-RHRVLAEKG----------EKKV 422

  Fly   512 MLKQVAFGEKL-H----------GNNRFEGYCKDLADLLAKELGINYELRLV----KDGNYGSEK 561
            :...|..|.|: |          |.|...|:|.::.......  .||||..:    .:.|.....
plant   423 LRVLVTAGNKVPHLVSVRPDPETGVNTVSGFCVEVFKTCIAP--FNYELEFIPYRGNNDNLAYLL 485

  Fly   562 SSAHGGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFM 626
            |:....:|..||::            |||:.|...:||:.|:..:||.|:..|  |::.|:::|.
plant   486 STQRDKYDAAVGDI------------TITSNRSLYVDFTLPYTDIGIGILTVK--KKSQGMWTFF 536

  Fly   627 NPLSQEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIG 691
            :|..:.:|::....::...||::.|.|               |.:|:
plant   537 DPFEKSLWLASGAFFVLTGIVVWLVER---------------SVNPE------------------ 568

  Fly   692 GAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCD 756
                                           ..||.|...:::    :|  |.||...|..:.
plant   569 -------------------------------FQGSWGQQLSMM----LW--FGFSTIVFAHRE-- 594

  Fly   757 LSPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGST 821
             ..:.:|.|.....|.|..|||.|||:|||.:..|:.||              ::.:..:..|||
plant   595 -KLQKMSSRFLVIVWVFVVLILTSSYSANLTSTKTISRM--------------QLNHQMVFGGST 644

  Fly   822 WDFFRRSQIGLHNKMWEYMNSRKHVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTM 886
            ...  .:::|..|.:..|....:       |..:..|.|.....::|:.:..|::|
plant   645 TSM--TAKLGSINAVEAYAQLLR-------DGTLNHVINEIPYLSILIGNYPNDFV--------- 691

  Fly   887 KVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAE-----------CST 940
            ...|..:|.|||.....||.|...::..:..|:..| ::|...|.|::|.:           .||
plant   692 MTDRVTNTNGFGFMFQKGSDLVPKVSREIAKLRSLG-MLKDMEKKWFQKLDSLNVHSNTEEVAST 755

  Fly   941 HKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILEYCFRSRDSRS 987
            :.|.|.| ...:...:.|:|  :|.|....:.:|:  :.|.:|...|
plant   756 NDDDEAS-KRFTFRELRGLF--IIAGAAHVLVLAL--HLFHTRQEVS 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	74/464 (16%)
		ANF_receptor	55..461	CDD:279440	72/432 (17%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	90/466 (19%)
		Lig_chan	632..967	CDD:278489	65/345 (19%)
GLR1.1	NP_187061.1	PBP1_GABAb_receptor	31..397	CDD:107361	75/467 (16%)
		ANF_receptor	45..377	CDD:279440	72/432 (17%)
		Periplasmic_Binding_Protein_Type_2	421..737	CDD:304360	87/437 (20%)
		Lig_chan	542..781	CDD:278489	66/347 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.010