DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and GLR2

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_001318239.1	Gene:	GLR2 / 816231	AraportID:	AT2G17260	Length:	925	Species:	Arabidopsis thaliana

Alignment Length:	1064	Identity:	215/1064 - (20%)
Similarity:	395/1064 - (37%)	Gaps:	312/1064 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SFLLWLTWSSGGGGGSGVGVSAQPSLTEKIPLGAIFEQGTDEVQSAFKYAMLNHNLNVSSRRFEL 77
            ||::.|      |||..:...|..|....|.:||||...|          |.....|::.:..|
plant    11 SFIIVL------GGGLLLSEGASSSRPPVIKVGAIFGLNT----------MYGETANIAFKAAE- 58

  Fly    78 QAYVDVINTADAF----KLSRLICNQFSR-GVYSMLGA-----------VSPDSFDTLHSYSN-- 124
                :.:|:..:|    || |::.|...| |..|::||           :.|.:....|..|:
plant    59 ----EDVNSDPSFLGGSKL-RILMNDAKRSGFLSIMGALQFMETDVVAIIGPQTSIMAHVLSHLA 118

  Fly   125 ---TFQM-------PFVTP-WFPEKVLT-PSSGFLDFALSMRPDYHQAIIDTIQFYGWRKIIYLY 177
               |..|       |.::| .||..|.| ||..||     ||     ||.:.|.:|||..::.||
plant   119 NELTVPMLSFTALDPTLSPLQFPFFVQTAPSDLFL-----MR-----AIAEMITYYGWSDVVALY 173

  Fly   178 DSHDGLLRLQQIYQGLRPGNESFQVELVKRISNVS------------MAIEFLHTLEQIGRFENK 230
            :..|          ..|.|..:...||.:|...:|            ..:|.:..|.:|...|::
plant   174 NDDD----------NSRNGVTALGDELEERRCKISYKAVLPLDVVITSPVEIIEELIKIRGMESR 228

  Fly   231 HIVLDCPTEMAKQILIQHVRDLRLGRRTYHYLLSGLVMDDRWESEIIEFG------AIN-ITGFR 288
            .||::......|.|..:..| |.:..:.|.::.:      .|.|.:::..      .:| :...|
plant   229 VIVVNTFPNTGKMIFKEAER-LGMMEKGYVWIAT------TWLSSVLDSNLPLDTKLVNGVLTLR 286

  Fly   289 IVDTNRRLVREFYDSWK-RLDPQMSVGAGRESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNN 352
            :...:.|..|:|...|| :|....::|     ::......||.|:::..|...:|.
plant   287 LHTPDSRKKRDFAARWKNKLSNNKTIG-----LNVYGLYAYDTVWIIARAVKTLLE--------- 337

  Fly   353 VQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWV 417
                                               |||..:.|:....|.:...||:.:.    :
plant   338 -----------------------------------AGGNLSFSNDAKLGSLKGEALNLSA----L 363

  Fly   418 NAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLN 482
            :.::.|.::..|:...::.||||.::|:.|...:..:..::.: |:..:.::..|::.:||..:.
plant   364 SRFDQGSQLLDYIVHTKMSGLTGPVQFHPDRSMLQPSYDIINL-VDDRVHQIGYWSNYSGLSIVP 427

  Fly   483 AKYVRLRPHVEFEKNRTYIV------TTVLEEPYIML---KQVAFG-----------EKLHG-NN 526
            .:....:|......|:....      |:|....:|..   :::..|           .:::| :|
plant   428 PESFYSKPPNRSSSNQHLNSVTWPGGTSVTPRGWIFRNNGRRLRIGVPDRASFKDFVSRVNGSSN 492

  Fly   527 RFEGYCKDLADLLAKELG--INYELRLVKDG----NYGSEKSSAHGGWDGMVGELVRK-----EA 580
            :.:|||.|:.:...|.|.  :.:|.....||    ||               .|||.|     :.
plant   493 KVQGYCIDVFEAAVKLLSYPVPHEFIFFGDGLTNPNY---------------NELVNKVTTGVDF 542

  Fly   581 DIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVS 645
            |..:..:.|..:|.|::||::|::..|: :::....:.....::|:.|.:..:|......::.|.
plant   543 DAVVGDIAIVTKRTRIVDFTQPYIESGL-VVVAPVTRLNENPWAFLRPFTLPMWAVTASFFVIVG 606

  Fly   646 IVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAA 710
            ..::.:......|:|                                       |||.....|.
plant   607 AAIWILEHRINDEFR---------------------------------------GPPRRQIITI- 631

  Fly   711 GAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFT 775
                                        :|  |.||...|..:...:   |..||:....|.|..
plant   632 ----------------------------LW--FTFSTMFFSHRETTV---STLGRMVLLIWLFVV 663

  Fly   776 LILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGL------HN 834
            ||:.|||||:|.:.|||:::.:||...:.|...|                  .:||.      .|
plant   664 LIITSSYTASLTSILTVQQLNSPIKGVDTLISST------------------GRIGFQVGSFAEN 710

  Fly   835 KMWEYMNSRKHVFVP--TYDEGIKRVRNSKGKYALLVESPKNEYVN--AREPCDTMKVGRNLDTK 895
            .|.:.:|......||  :.:|....::|  |..|.:|:  :..|::  ..:.|.....|:.....
plant   711 YMTDELNIASSRLVPLASPEEYANALQN--GTVAAIVD--ERPYIDLFLSDYCKFAIRGQEFTRC 771

  Fly   896 GFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETSHSE-LSLSNVAGI 959
            |:|.|.|..|.|...::.|:|.|.|.|||.|:.:: |..|:.||:....::..|| |::.:..|:
plant   772 GWGFAFPRDSPLAVDMSTAILGLSETGELQKIHDR-WLSKSNCSSPHGSQSGDSEQLNVHSFWGM 835

  Fly   960 FYILIGGLLVSVFV----AILEYC 979
            |.::....||::|:    .|.::|
plant   836 FLVVGIACLVALFIHFFKIIRDFC 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	95/484 (20%)
		ANF_receptor	55..461	CDD:279440	88/455 (19%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	96/482 (20%)
		Lig_chan	632..967	CDD:278489	71/345 (21%)
GLR2	NP_001318239.1	PBP1_GABAb_receptor	35..424	CDD:107361	96/485 (20%)
		GluR_Plant	468..808	CDD:270404	90/451 (20%)
		Lig_chan	594..843	CDD:306551	71/344 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.820