DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and grik5

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_001315085.1	Gene:	grik5 / 798791	ZFINID:	ZDB-GENE-070821-6	Length:	1067	Species:	Danio rerio

Alignment Length:	1244	Identity:	357/1244 - (28%)
Similarity:	550/1244 - (44%)	Gaps:	322/1244 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 VSAQPSLTEKIP------LGAIFEQ----GTDEVQSAFKYAMLNHNLNVSSRRFELQAYVDVINT 86
            |:..||...:.|      :.||.:.    |..|   ....|:...|:| |......:|.|:|
Zfish    21 VTMPPSSLSQTPVLSSVRMAAILDDSSVCGRGE---RLALALARENIN-SVMENPARARVEV--- 78

  Fly    87 ADAFKLSR--------LICNQFSRGVYSMLG-AVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLTP 142
             |.|:|.:        .:|....:||.|::| |.||.|...:.......::|.|... ||:  ||
Zfish    79 -DIFELQKDSQYETTDTMCQILPKGVVSVIGPASSPASGSIVSHICGEKEIPHVKIG-PEE--TP 139

  Fly   143 SSGFLDFA-LSMRP---DYHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVE 203
            ...:|.|| :::.|   |...||...::.:.:.....:....:.||||:               |
Zfish   140 RLPYLRFASVTLYPSNEDLSLAIGSILRSFSYPSASLVCAKAECLLRLE---------------E 189

  Fly   204 LVKR--ISNVSMAIEFLH-------TLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRTY 259
            |::|  ||..:::|..|.       .|::|...:...|::|....:: .::::...:|.:....|
Zfish   190 LIRRFLISRETLSIRMLDDNLDPTPLLKEIRDDKIATIIIDANASIS-YLILKKASELGMTSAFY 253

  Fly   260 HYLLSGLVMDDRWESEIIEFGAINITGFRIVDTNRRLVREFYD----SWKR---LDPQMSVGAGR 317
            .|:|:.:.....|..:|::..: ||.||.:.:|......||..    ||:.   ::|.
Zfish   254 KYILTTMDFPLLWLDDIVDEQS-NIVGFSMFNTTHPFYLEFIRSLNLSWREGCDINPY------- 310

  Fly   318 ESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGG 382
            ...:..:||::|||.|:|.|..::             .|||.:.|
Zfish   311 PGPALSSALLFDAVHVVVSAVQEL-------------NRSQEIGV-------------------- 342

  Fly   383 GGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDD 447
                                   :.|.|.:.:    .|:||..:..|||.||.:||||.::||..
Zfish   343 -----------------------KPLSCTSPQ----IWQHGTSLMNYLRMVEYDGLTGRVEFNSK 380

  Fly   448 GRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIM 512
            |:|.|||||::|.. .....::..|..:..|. :|:..:.:... |...|::.|:||:||.||:|
Zfish   381 GQRTNYTLHILEKH-RGGHKEIGIWYSNNTLL-MNSTSLDINVS-ETLANKSLIITTILENPYVM 442

  Fly   513 LKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVR 577
             :::.: ::..||.::||:|.|:...|:..|...|.::||.||.||:.:  .:|.|.||||||:.
Zfish   443 -RKINY-QEFEGNEQYEGFCVDMLRELSDILKFTYRIKLVDDGLYGAPE--PNGSWTGMVGELIN 503

  Fly   578 KEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYI 642
            ::||:|:||.|||:|||:|||||||||:|||||:.:..:.:.||.|||::|.|..:|:.::.:|:
Zfish   504 RKADLAVAAFTITSEREKVIDFSKPFMTLGISILYRVHIGRKPGYFSFLDPFSPAVWLFMLLAYL 568

  Fly   643 GVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQ 707
            .||.|||..:|.||:||.            :||
Zfish   569 AVSCVLFLSARLSPYEWY------------NPH-------------------------------- 589

  Fly   708 TAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWF 772
                            |........:.|::::.||.||.:..|||||.::.||::|.|..:..|:
Zfish   590 ----------------PCLRERRDLLENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWW 638

  Fly   773 FFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNKMW 837
            .||||:||||||||||||||:||..||.||:|||.||.:||||:..|||..||..|:...:.:||
Zfish   639 AFTLIIISSYTANLAAFLTVQRMEVPIESPDDLADQTNIQYGTIHGGSTMTFFMNSRYQTYQRMW 703

  Fly   838 EYMNSRK-HVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGIAT 901
            .||.|:: .|||.:.:|||.||.||  |||.|:||..|||..:.. |:..::|..|||||:||..
Zfish   704 NYMYSKQPSVFVKSTEEGIARVVNS--KYAFLLESTMNEYHRSLN-CNLTQIGGLLDTKGYGIGM 765

  Fly   902 PLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETSHSELSLSNVAGIFYILIGG 966
            ||||..:|.::||||.|:||..|..|:.:|| |..:|...:|...  ..|.:.|:.|||.:||.|
Zfish   766 PLGSPFRDELSLAVLQLQENNRLEILKRRWW-EGGKCPKEEDHRA--KGLGMENIGGIFVVLICG 827

  Fly   967 LLVSVFVAILEYCFRSRDS-------------------------------RSASS---------- 990
            |:::||||::|:.:.:|.|                               |:|.|
Zfish   828 LIIAVFVAVMEFVWSTRRSAETDEVRPLSCDRQYHSHTTVSVCQEMLTEFRNAVSCKKSSRLRRR 892

  Fly   991 ---GSGMGL----GMGLGG----------GMSGGSLGKANGSMMLGPSSAVPGGMPS----SHQR 1034
               .|.:.|    .:.||.          .:|.|.|....|.:..|..   |||.|:    ..||
Zfish   893 RPLSSSLALRHPTRITLGAPRPLRLVREMRLSNGKLYSGTGPLTGGSG---PGGGPTDMGPGPQR 954

  Fly  1035 STLTDTMHAKAKLTIQASRDYDNGRVGYLNCASLQYYPPAQLSATPPDAGDSLHMNAHGQVXHEH 1099
             .|.|.:.|.:...:...                   |||.....|...       .|.:: .|.
Zfish   955 -LLEDPLGANSTPAVALG-------------------PPAVTVPLPRGC-------THVRICQEC 992

  Fly  1100 AQESRLXRTPCAPTIRRIMANSRQETEKMMGGGHGGTVTVSVPATCSSSMNGSHEGSLALSPSSG 1164
            .:...| .|.|.    ||..:|             ..:....|....||.|...||...|||..
Zfish   993 RRIQSLRTTSCT----RIPPSS-------------APLPRLAPPPPHSSSNTDSEGGGGLSPCR- 1039

  Fly  1165 SATLMRHSP 1173
                :.|||
Zfish  1040 ----IGHSP 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	105/473 (22%)
		ANF_receptor	55..461	CDD:279440	99/434 (23%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	183/441 (41%)
		Lig_chan	632..967	CDD:278489	128/335 (38%)
grik5	NP_001315085.1	PBP1_iGluR_Kainate_KA1_2	38..412	CDD:107389	105/470 (22%)
		ANF_receptor	55..392	CDD:279440	98/428 (23%)
		Periplasmic_Binding_Protein_Type_1	<313..383	CDD:299141	29/129 (22%)
		Periplasmic_Binding_Protein_Type_2	427..797	CDD:304360	182/437 (42%)
		Lig_chan	558..828	CDD:278489	128/335 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590945
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750