Protein Alignment GluRIB and grik5

DIOPT Version :10

• Sequence 1: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: NP_001315085.1
• Gene: grik5 / 798791
• ZFINID: ZDB-GENE-070821-6
• Length: 1067
• Species: Danio rerio
• Alignment Length: 1244
• Identity: 357/1244 - (28%)
• Similarity: 550/1244 - (44%)
• Gaps: 322/1244 - (25%)

  Fly    32 VSAQPSLTEKIP------LGAIFEQ----GTDEVQSAFKYAMLNHNLNVSSRRFELQAYVDVINT 86
            |:..||...:.|      :.||.:.    |..|   ....|:...|:| |......:|.|:|
Zfish    21 VTMPPSSLSQTPVLSSVRMAAILDDSSVCGRGE---RLALALARENIN-SVMENPARARVEV--- 78

  Fly    87 ADAFKLSR--------LICNQFSRGVYSMLG-AVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLTP 142
             |.|:|.:        .:|....:||.|::| |.||.|...:.......::|.|... ||:  ||
Zfish    79 -DIFELQKDSQYETTDTMCQILPKGVVSVIGPASSPASGSIVSHICGEKEIPHVKIG-PEE--TP 139

  Fly   143 SSGFLDFA-LSMRP---DYHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVE 203
            ...:|.|| :::.|   |...||...::.:.:.....:....:.||||:               |
Zfish   140 RLPYLRFASVTLYPSNEDLSLAIGSILRSFSYPSASLVCAKAECLLRLE---------------E 189

  Fly   204 LVKR--ISNVSMAIEFLH-------TLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRTY 259
            |::|  ||..:::|..|.       .|::|...:...|::|....:: .::::...:|.:....|
Zfish   190 LIRRFLISRETLSIRMLDDNLDPTPLLKEIRDDKIATIIIDANASIS-YLILKKASELGMTSAFY 253

  Fly   260 HYLLSGLVMDDRWESEIIEFGAINITGFRIVDTNRRLVREFYD----SWKR---LDPQMSVGAGR 317
            .|:|:.:.....|..:|::..: ||.||.:.:|......||..    ||:.   ::|.
Zfish   254 KYILTTMDFPLLWLDDIVDEQS-NIVGFSMFNTTHPFYLEFIRSLNLSWREGCDINPY------- 310

  Fly   318 ESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGG 382
            ...:..:||::|||.|:|.|..::             .|||.:.|
Zfish   311 PGPALSSALLFDAVHVVVSAVQEL-------------NRSQEIGV-------------------- 342

  Fly   383 GGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDD 447
                                   :.|.|.:.:    .|:||..:..|||.||.:||||.::||..
Zfish   343 -----------------------KPLSCTSPQ----IWQHGTSLMNYLRMVEYDGLTGRVEFNSK 380

  Fly   448 GRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIM 512
            |:|.|||||::|.. .....::..|..:..|. :|:..:.:... |...|::.|:||:||.||:|
Zfish   381 GQRTNYTLHILEKH-RGGHKEIGIWYSNNTLL-MNSTSLDINVS-ETLANKSLIITTILENPYVM 442

  Fly   513 LKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVR 577
             :::.: ::..||.::||:|.|:...|:..|...|.::||.||.||:.:  .:|.|.||||||:.
Zfish   443 -RKINY-QEFEGNEQYEGFCVDMLRELSDILKFTYRIKLVDDGLYGAPE--PNGSWTGMVGELIN 503

  Fly   578 KEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYI 642
            ::||:|:||.|||:|||:|||||||||:|||||:.:..:.:.||.|||::|.|..:|:.::.:|:
Zfish   504 RKADLAVAAFTITSEREKVIDFSKPFMTLGISILYRVHIGRKPGYFSFLDPFSPAVWLFMLLAYL 568

  Fly   643 GVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQ 707
            .||.|||..:|.||:||.            :||
Zfish   569 AVSCVLFLSARLSPYEWY------------NPH-------------------------------- 589

  Fly   708 TAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWF 772
                            |........:.|::::.||.||.:..|||||.::.||::|.|..:..|:
Zfish   590 ----------------PCLRERRDLLENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWW 638

  Fly   773 FFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNKMW 837
            .||||:||||||||||||||:||..||.||:|||.||.:||||:..|||..||..|:...:.:||
Zfish   639 AFTLIIISSYTANLAAFLTVQRMEVPIESPDDLADQTNIQYGTIHGGSTMTFFMNSRYQTYQRMW 703

  Fly   838 EYMNSRK-HVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGIAT 901
            .||.|:: .|||.:.:|||.||.||  |||.|:||..|||..:.. |:..::|..|||||:||..
Zfish   704 NYMYSKQPSVFVKSTEEGIARVVNS--KYAFLLESTMNEYHRSLN-CNLTQIGGLLDTKGYGIGM 765

  Fly   902 PLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETSHSELSLSNVAGIFYILIGG 966
            ||||..:|.::||||.|:||..|..|:.:|| |..:|...:|...  ..|.:.|:.|||.:||.|
Zfish   766 PLGSPFRDELSLAVLQLQENNRLEILKRRWW-EGGKCPKEEDHRA--KGLGMENIGGIFVVLICG 827

  Fly   967 LLVSVFVAILEYCFRSRDS-------------------------------RSASS---------- 990
            |:::||||::|:.:.:|.|                               |:|.|
Zfish   828 LIIAVFVAVMEFVWSTRRSAETDEVRPLSCDRQYHSHTTVSVCQEMLTEFRNAVSCKKSSRLRRR 892

  Fly   991 ---GSGMGL----GMGLGG----------GMSGGSLGKANGSMMLGPSSAVPGGMPS----SHQR 1034
               .|.:.|    .:.||.          .:|.|.|....|.:..|..   |||.|:    ..||
Zfish   893 RPLSSSLALRHPTRITLGAPRPLRLVREMRLSNGKLYSGTGPLTGGSG---PGGGPTDMGPGPQR 954

  Fly  1035 STLTDTMHAKAKLTIQASRDYDNGRVGYLNCASLQYYPPAQLSATPPDAGDSLHMNAHGQVXHEH 1099
             .|.|.:.|.:...:...                   |||.....|...       .|.:: .|.
Zfish   955 -LLEDPLGANSTPAVALG-------------------PPAVTVPLPRGC-------THVRICQEC 992

  Fly  1100 AQESRLXRTPCAPTIRRIMANSRQETEKMMGGGHGGTVTVSVPATCSSSMNGSHEGSLALSPSSG 1164
            .:...| .|.|.    ||..:|             ..:....|....||.|...||...|||..
Zfish   993 RRIQSLRTTSCT----RIPPSS-------------APLPRLAPPPPHSSSNTDSEGGGGLSPCR- 1039

  Fly  1165 SATLMRHSP 1173
                :.|||
Zfish  1040 ----IGHSP 1044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..480	CDD:380603	106/475 (22%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	183/441 (41%)
		Lig_chan	630..966	CDD:459656	129/336 (38%)
grik5	NP_001315085.1	PBP1_iGluR_Kainate_KA1_2	36..414	CDD:380616	105/474 (22%)
		Periplasmic_Binding_Protein_Type_2	427..797	CDD:473866	182/437 (42%)