DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIB and grid1a

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	XP_021323097.1	Gene:	grid1a / 793756	ZFINID:	ZDB-GENE-120411-28	Length:	1044	Species:	Danio rerio

Alignment Length:	1027	Identity:	267/1027 - (25%)
Similarity:	442/1027 - (43%)	Gaps:	210/1027 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 IPLGAIFEQGT---DEV-QSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSR 102
            |.:||||||..   ||| |.|.....||.::..|.|   :...:.:|...:.|:..:..|...::
Zfish    24 IHIGAIFEQNAIRDDEVFQLAISDLSLNDDILQSER---ITHSIKLIEPNNPFQAVQEACELMNQ 85

  Fly   103 GVYSMLGAVSPDSFDTLHSYSNTFQMPFV--------TPWFPEKVLTPSSGFLDFALSMRPD--Y 157
            |:.:::.:....:.:.|.|.::...:|.:        || ..|..|.||.....:.|:.||.  .
Zfish    86 GILALVSSTGCAAANALQSLTDAMHIPHLFIQRNGDGTP-RAECQLNPSPDGERYTLAARPPVRL 149

  Fly   158 HQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQ-IYQGLRPGNESFQVELVKRISNVSMAIEFLHTL 221
            :..:|..:....|.|.|..|||...:..|:. :.|..|.|.:....::.:.::.|...:.....:
Zfish   150 NDVMITLVSELRWHKFIVFYDSEYDVRGLRGFLDQASRMGLDVSLQQVDRNVTKVFSTLFSTMRM 214

  Fly   222 EQIGRFEN---KHIVLDCPTEMAKQILIQHVRDLRLGRRTYHYLLSGLVMDDRWESEIIEFGAIN 283
            |::.|:.:   :.|:|..|  ...|:.|....:..|..:..|::.:...:.|....|::......
Zfish   215 EELNRYRDTLRRAILLLSP--RTAQVFIHQAVETNLASKDSHWVYANEEVSDTEIMELVHSALGR 277

  Fly   284 ITGFRIV-----DTNRRLVREFYDSWKRL-DPQMSVGAGRESISAQAALMYDAVFVLVEAFNKIL 342
            :|..|.:     |||.|.:|..:.....| |||...   .:|:...:..:||:|.:|..||   .
Zfish   278 MTVIRQIFPLWRDTNIRCMRNNHRISSLLCDPQEGY---LQSLEVSSLYLYDSVLMLANAF---Y 336

  Fly   343 RKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRA 407
            ||..|:..::                                                  |||
Zfish   337 RKLEDRKWHS--------------------------------------------------MAS-- 349

  Fly   408 LDC--NTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVV----EMTVNSAM 466
            |:|  .:.|.|...|...|.|    :|..|.||||.:.|..:|...:....::    ..|....:
Zfish   350 LNCMRKSTKPWNGGWSMLDTI----QKGRISGLTGLMDFRSNGANSHVQFEILGTSYSETFGKDV 410

  Fly   467 VKVAEWNDDAGLQPLNAKYVRLRPHVEFEKNR--------TYIVTTVLEEPYIMLKQVAFGEKLH 523
            .::|.|:.|.||            :....:||        |..|.|:||||::|:.:...|:.
Zfish   411 KRLATWDSDRGL------------NGSLRENRADHGMQGITLKVVTLLEEPFVMVAENILGQP-- 461

  Fly   524 GNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMT 588
              .|::|:..|:.|.|||.||..||:..|.|..|||.::  :|.|:||:|||:.|.||:||:|:|
Zfish   462 --KRYKGFSIDVLDALAKILGFKYEMYQVADAKYGSPQT--NGSWNGMIGELIGKRADVAISAIT 522

  Fly   589 ITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSR 653
            ||.|||.|:||||.::...:.|::.| .::...:||.:.|....:|..:..:...|.:::|.:.|
Zfish   523 ITPERENVVDFSKRYLDYSVGILMTK-TEERLNIFSLLAPFDLAVWACIAAAIPVVGVMVFLLRR 586

  Fly   654 FSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAA 718
            .          |..:||:                          ||||..|.:.|.:..:|:
Zfish   587 V----------QSVRSQN--------------------------PPGPHQPASVTTSFQSAI--- 612

  Fly   719 LSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYT 783
                                     |....||:|||.:....|::.|||..||:.||||:.||||
Zfish   613 -------------------------WIVYGAFVQQGGESFMSSMALRIAMGSWWLFTLIVCSSYT 652

  Fly   784 ANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFR------RSQIGLHNKMWEYMNS 842
            |||||:|||.||...|.:.:||:.|:|:.|||:...:.:::||      ..|.....::|..:|.
Zfish   653 ANLAAYLTVSRMDNAIRTFQDLSKQSEINYGTVRESAVFEYFRVKGTNPLEQDSTFAELWRTINK 717

  Fly   843 RK----HVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVN-AREPCDTMKVGRNLDTKGFGIATP 902
            .:    .|..|.  |||::|:  :..||.|.:....||.. ..:.|..:..|..:.:||:|:|..
Zfish   718 NQGQDNSVTSPA--EGIRKVK--RDPYAFLWDMAVLEYAALTDDDCTLVVTGNGMSSKGYGLALQ 778

  Fly   903 LGSALKDPINLAVLTLKENGELIKLRNKWWYEKAEC--STHKDGETSHSELSLSNVAGIFYILIG 965
            .||..:|..:..:|.|:|.|:|..|:.|||..|..|  ..|.:.:|....|.|.:.||:|.||..
Zfish   779 HGSPYRDLFSQKILDLQEKGDLDILKQKWWPRKGRCDLDKHAEPQTEGRALRLHSFAGVFCILAA 843

  Fly   966 GLLVSVFVAILEYCF---RSRDSRSASSGSGMGLGMGLGGGMSGGSLGKANG 1014
            |||::..||.||..:   |.:.::......|..|.| :.|.::...:..|.|
Zfish   844 GLLLACLVAALESWWNGPRCQRAQPKEDTKGCALEM-VSGSLAYNEIAPAAG 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	97/464 (21%)
		ANF_receptor	55..461	CDD:279440	85/432 (20%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	143/459 (31%)
		Lig_chan	632..967	CDD:278489	97/347 (28%)
grid1a	XP_021323097.1	Periplasmic_Binding_Protein_Type_1	25..424	CDD:324556	99/478 (21%)
		PBP2_iGluR_delta_1	437..809	CDD:270448	139/446 (31%)
		DNA_pol3_gamma3	<915..1044	CDD:331207
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590907
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740