DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and Grid2

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_077355.2	Gene:	Grid2 / 79220	RGDID:	68368	Length:	1007	Species:	Rattus norvegicus

Alignment Length:	999	Identity:	231/999 - (23%)
Similarity:	434/999 - (43%)	Gaps:	211/999 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 IPLGAIFEQGTDEVQSAFKYAM--LNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGV 104
            |.:||||::...:....|:.|:  ||.|..:.... ::...|..::..:.|:..:..|...::|:
  Rat    27 IHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTE-KITFSVTFVDGNNPFQAVQEACELMNQGI 90

  Fly   105 YSMLGAVSPDSFDTLHSYSNTFQMPFV-----TPWFPEK--VLTPSSGFLDFALSMRPDYH--QA 160
            .:::.::...|..:|.|.::...:|.:     |...|..  .||.|:...|:.||:||..:  :.
  Rat    91 LALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYLNEV 155

  Fly   161 IIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVKRISNVSMAIEFLH---TLE 222
            |:..:..|.|:|.|..|||...:..:|:...  :...:...|.|.|..:|::..|..|.   .:|
  Rat   156 ILRVVTEYAWQKFIIFYDSEYDIRGIQEFLD--KVSQQGMDVALQKVENNINKMITTLFDTMRIE 218

  Fly   223 QIGRFEN--KHIVLDCPTEMAKQILIQHVRDLRLGRRTYHYLLSGLVMDDRWESEIIEFGAINIT 285
            ::.|:.:  :..:|......||. .|..|.:..|.....|:::....::|....|::......:|
  Rat   219 ELNRYRDTLRRAILVMNPATAKS-FISEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLT 282

  Fly   286 GFRIVDTNRRLVREFYDSWKRLDPQMSVGAGR-------------ESISAQAALMYDAVFVLVEA 337
                      ::|:.:...:.:..:...|..|             :::......:||.|.:|..|
  Rat   283 ----------IIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANA 337

  Fly   338 FNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGG 402
            |:|.|..:...                                                     .
  Rat   338 FHKKLEDRKWH-----------------------------------------------------S 349

  Fly   403 MASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMT----VN 463
            |||  |.|.....  ..|:.|..:...::|..:.|||||::|.::|...|....::...    :.
  Rat   350 MAS--LSCIRKNS--KPWQGGRSMLETIKKGGVNGLTGDLEFGENGGNPNVHFEILGTNYGEELG 410

  Fly   464 SAMVKVAEWNDDAGLQ-PLNAKYVRLRPHVEFEKNRTYI---VTTVLEEPYIMLKQVAFGEKLHG 524
            ..:.|:..||...||. .|..|        :.|.|...:   |.||||||::|:.:...|:.
  Rat   411 RGVRKLGCWNPVTGLNGSLTDK--------KLENNMRGVVLRVVTVLEEPFVMVSENVLGKP--- 464

  Fly   525 NNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTI 589
             .:::|:..|:.|.|:..||.|||:.:..|..|||.:..  |.|:|:|||||.|.|||.|:|:||
  Rat   465 -KKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQED--GTWNGLVGELVFKRADIGISALTI 526

  Fly   590 TAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRF 654
            |.:||.|:||:..:|...:.::::: .::|..:|:.:.|....:|..:..:.:.|.::::.::..
  Rat   527 TPDRENVVDFTTRYMDYSVGVLLRR-AEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWL 590

  Fly   655 SPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAAL 719
            :|...::                                           |:.|:.
  Rat   591 NPPRLQM-------------------------------------------GSMTST--------- 603

  Fly   720 SAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTA 784
                              :::||.||...:|:|||.::...:::.|:...:|:.|.||:||||||
  Rat   604 ------------------TLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTA 650

  Fly   785 NLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQI------GLHNKMWEYMN-- 841
            |||||||:.|:.:.|.|.:||:.||::.|||:|..:.:...|...:      .::::||..:|
  Rat   651 NLAAFLTITRIESSIQSLQDLSKQTDIPYGTVLDSAVYQHVRMKGLNPFERDSMYSQMWRMINRS 715

  Fly   842 --SRKHVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREP-CDTMKVGRNLDTKGFGIATPL 903
              |..:|.  ....||::|:  .|.||.:.::...|||...:| |....||..:..:|:|||...
  Rat   716 NGSENNVL--ESQAGIQKVK--YGNYAFVWDAAVLEYVAINDPDCSFYTVGNTVADRGYGIALQH 776

  Fly   904 GSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHK--DGETSHSELSLSNVAGIFYILIGG 966
            ||..:|..:..:|.|:::|::..|::|||.:..:|..:.  |.:.....|.:.::||:|.||..|
  Rat   777 GSPYRDVFSQRILELQQSGDMDILKHKWWPKNGQCDLYSSVDAKQKGGALDIKSLAGVFCILAAG 841

  Fly   967 LLVSVFVAILE-YCFRSRDSRSAS 989
            :::|..:|:|| :..|.:.||..|
  Rat   842 IVLSCLIAVLETWWSRRKGSRVPS 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	84/467 (18%)
		ANF_receptor	55..461	CDD:279440	77/434 (18%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	124/454 (27%)
		Lig_chan	632..967	CDD:278489	83/347 (24%)
Grid2	NP_077355.2	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		66/331 (20%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:415822	86/471 (18%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	122/446 (27%)
		Interaction with AP4M1. /evidence=ECO:0000269\|PubMed:14572453	921..991
		PDZ-binding. /evidence=ECO:0000250	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810