Protein Alignment GluRIB and Grid2

DIOPT Version :10

• Sequence 1: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: NP_077355.2
• Gene: Grid2 / 79220
• RGDID: 68368
• Length: 1007
• Species: Rattus norvegicus
• Alignment Length: 999
• Identity: 231/999 - (23%)
• Similarity: 434/999 - (43%)
• Gaps: 211/999 - (21%)

  Fly    42 IPLGAIFEQGTDEVQSAFKYAM--LNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGV 104
            |.:||||::...:....|:.|:  ||.|..:.... ::...|..::..:.|:..:..|...::|:
  Rat    27 IHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTE-KITFSVTFVDGNNPFQAVQEACELMNQGI 90

  Fly   105 YSMLGAVSPDSFDTLHSYSNTFQMPFV-----TPWFPEK--VLTPSSGFLDFALSMRPDYH--QA 160
            .:::.::...|..:|.|.::...:|.:     |...|..  .||.|:...|:.||:||..:  :.
  Rat    91 LALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYLNEV 155

  Fly   161 IIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVKRISNVSMAIEFLH---TLE 222
            |:..:..|.|:|.|..|||...:..:|:...  :...:...|.|.|..:|::..|..|.   .:|
  Rat   156 ILRVVTEYAWQKFIIFYDSEYDIRGIQEFLD--KVSQQGMDVALQKVENNINKMITTLFDTMRIE 218

  Fly   223 QIGRFEN--KHIVLDCPTEMAKQILIQHVRDLRLGRRTYHYLLSGLVMDDRWESEIIEFGAINIT 285
            ::.|:.:  :..:|......||. .|..|.:..|.....|:::....::|....|::......:|
  Rat   219 ELNRYRDTLRRAILVMNPATAKS-FISEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLT 282

  Fly   286 GFRIVDTNRRLVREFYDSWKRLDPQMSVGAGR-------------ESISAQAALMYDAVFVLVEA 337
                      ::|:.:...:.:..:...|..|             :::......:||.|.:|..|
  Rat   283 ----------IIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANA 337

  Fly   338 FNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGG 402
            |:|.|..:...                                                     .
  Rat   338 FHKKLEDRKWH-----------------------------------------------------S 349

  Fly   403 MASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMT----VN 463
            |||  |.|.....  ..|:.|..:...::|..:.|||||::|.::|...|....::...    :.
  Rat   350 MAS--LSCIRKNS--KPWQGGRSMLETIKKGGVNGLTGDLEFGENGGNPNVHFEILGTNYGEELG 410

  Fly   464 SAMVKVAEWNDDAGLQ-PLNAKYVRLRPHVEFEKNRTYI---VTTVLEEPYIMLKQVAFGEKLHG 524
            ..:.|:..||...||. .|..|        :.|.|...:   |.||||||::|:.:...|:.
  Rat   411 RGVRKLGCWNPVTGLNGSLTDK--------KLENNMRGVVLRVVTVLEEPFVMVSENVLGKP--- 464

  Fly   525 NNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTI 589
             .:::|:..|:.|.|:..||.|||:.:..|..|||.:..  |.|:|:|||||.|.|||.|:|:||
  Rat   465 -KKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQED--GTWNGLVGELVFKRADIGISALTI 526

  Fly   590 TAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRF 654
            |.:||.|:||:..:|...:.::::: .::|..:|:.:.|....:|..:..:.:.|.::::.::..
  Rat   527 TPDRENVVDFTTRYMDYSVGVLLRR-AEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWL 590

  Fly   655 SPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAAL 719
            :|...::                                           |:.|:.
  Rat   591 NPPRLQM-------------------------------------------GSMTST--------- 603

  Fly   720 SAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTA 784
                              :::||.||...:|:|||.::...:::.|:...:|:.|.||:||||||
  Rat   604 ------------------TLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTA 650

  Fly   785 NLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQI------GLHNKMWEYMN-- 841
            |||||||:.|:.:.|.|.:||:.||::.|||:|..:.:...|...:      .::::||..:|
  Rat   651 NLAAFLTITRIESSIQSLQDLSKQTDIPYGTVLDSAVYQHVRMKGLNPFERDSMYSQMWRMINRS 715

  Fly   842 --SRKHVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREP-CDTMKVGRNLDTKGFGIATPL 903
              |..:|.  ....||::|:  .|.||.:.::...|||...:| |....||..:..:|:|||...
  Rat   716 NGSENNVL--ESQAGIQKVK--YGNYAFVWDAAVLEYVAINDPDCSFYTVGNTVADRGYGIALQH 776

  Fly   904 GSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHK--DGETSHSELSLSNVAGIFYILIGG 966
            ||..:|..:..:|.|:::|::..|::|||.:..:|..:.  |.:.....|.:.::||:|.||..|
  Rat   777 GSPYRDVFSQRILELQQSGDMDILKHKWWPKNGQCDLYSSVDAKQKGGALDIKSLAGVFCILAAG 841

  Fly   967 LLVSVFVAILE-YCFRSRDSRSAS 989
            :::|..:|:|| :..|.:.||..|
  Rat   842 IVLSCLIAVLETWWSRRKGSRVPS 865

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..480	CDD:380603	86/470 (18%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	124/454 (27%)
		Lig_chan	630..966	CDD:459656	83/348 (24%)
Grid2	NP_077355.2	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250|UniProtKB:O43424	24..345		66/331 (20%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:471960	86/471 (18%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	122/446 (27%)
		Interaction with AP4M1. /evidence=ECO:0000269|PubMed:14572453	921..991
		PDZ-binding. /evidence=ECO:0000250	1005..1007