DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and grin3ba

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	XP_021323058.1	Gene:	grin3ba / 566411	ZFINID:	ZDB-GENE-070912-354	Length:	1118	Species:	Danio rerio

Alignment Length:	824	Identity:	181/824 - (21%)
Similarity:	308/824 - (37%)	Gaps:	231/824 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   423 GDKISRYLRKVEIEGLTGDIKFNDDGRRV--NYTLHVVEMTVN----SAMVKVAEWN------DD 475
            |..::|:|......||||.::......||  :...|:..:..:    .:.|.||.|.      ::
Zfish   359 GQYLARFLSNTSFTGLTGPVRVERSFSRVLTSQRFHIWSLQRDPLGQPSWVTVASWQSGRLELEE 423

  Fly   476 AGLQP--------------LNAKY--------VRLRPHVEFEKNRTYIVTTVLEEPYIMLKQV-- 516
            .||.|              |..::        .|||            |.|::|.|::..::|
Zfish   424 QGLWPGVTQHQREDGPGIRLGGRWQAGLPVAGSRLR------------VVTLVEHPFVFTREVDE 476

  Fly   517 -----------------------AFGEKLHGNNR---------FEGYCKDLADLLAKELGINYEL 549
                                   .|.|....|:.         ..|||.||.:.||:::...::|
Zfish   477 EGQCPAGQLCLDPQTNNSEVLNQLFRELEQTNSSSLPTDMRKCCYGYCIDLLEKLAEDMHFEFDL 541

  Fly   550 RLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKK 614
            .:|.||.||:.|.   |.|.|:||:|:...||:|:.:.:|.:.|.|||||:.||.|..:.|:::.
Zfish   542 YIVGDGKYGAWKG---GRWSGLVGDLLSGVADMAVTSFSINSARSRVIDFTSPFFSTSLGILVRS 603

  Fly   615 PVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSP---DPHA 676
            .....| :.:||.||...:||.:   ::.:.|...|::.:   ||          .||   .||
Zfish   604 KDTAAP-IGAFMWPLHWSMWVGI---FVALHITALFITLY---EW----------NSPFGMTPH- 650

  Fly   677 HHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWN 741
                                                              |.:...|.:..|..|
Zfish   651 --------------------------------------------------GRNRIRVFSYSSALN 665

  Fly   742 SFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLA 806
            ..:..|  |.:.....:|:..:||.....|..|.|:::|||||||||.:..|:....::...|:.
Zfish   666 LCYAIL--FGRTVASKTPKCWTGRFLMNLWAIFCLLVLSSYTANLAAVMVGEKTFEEVSGIHDVK 728

  Fly   807 M---QTEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYMNSRKHVFVPTYDEGIKRVRNSKGKY-AL 867
            :   ....::||:...|..|:.::|...:|    |||   :....||..:|:..::....:. |.
Zfish   729 LHHPSLGFRFGTVRESSAEDYVKKSFPEMH----EYM---RRFNKPTTPDGVSTLKTDPPQLDAF 786

  Fly   868 LVESPKNEY-VNAREPCDTMKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKW 931
            :::....:| |:....|..:.||:....:|:||..|..|.|...::..|...|.:|.:..|.:|
Zfish   787 IMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTRNVSEYVSRYKSDGYMDMLHDK- 850

  Fly   932 WYEKAECSTHKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILEYCF------------RSRD 984
            ||:...|.......|...::.:.:.:|:|.:|..|:..::...:.|:.|            |.:.
Zfish   851 WYKVVPCGKRVFAVTETLQMGIQHFSGLFVLLCVGVAGALLTLLGEHAFFRFILPHLRHQQRFKY 915

  Fly   985 SRSASSGSGMGLGMGLGGGMSGGS----------LGKANGSMMLGPSSAVPGGMPSSHQRSTLTD 1039
            ....|......:.||........:          |.:......|.|||:.|   ||:...||.|.
Zfish   916 WLHTSQKIHRAINMGCDDERKSEAESSDRCPTLCLSENCNLHRLPPSSSSP---PSTSSTSTTTT 977

  Fly  1040 TMHAKAKLTIQASRD--YDNGRVGYLNCASLQYYPPAQLSATPPDAGDSLHMNAHGQVXHEHAQE 1102
            ..:.:   :::|.|:  ..|.|| :.|..:|..|   ||.|.|           ||      |:.
Zfish   978 KWNNQ---SVKAGREAKEQNKRV-HFNLETLNSY---QLQAPP-----------HG------AER 1018

  Fly  1103 SRLXRTPCAPTIRRIMANSRQETEKMMGGGHGGTVTVSVPATCS 1146
            .|. .....||  ::.:|         ||.:.....|..|.|||
Zfish  1019 GRRGLVGSPPT--QLCSN---------GGPNPSLSLVLSPLTCS 1051

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	14/66 (21%)
		ANF_receptor	55..461	CDD:279440	10/39 (26%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	111/482 (23%)
		Lig_chan	632..967	CDD:278489	69/342 (20%)
grin3ba	XP_021323058.1	Periplasmic_Binding_Protein_Type_1	26..428	CDD:324556	16/68 (24%)
grin3ba	XP_021323058.1	PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	112/487 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590928
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740