DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIB and grik1b

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	XP_690040.5	Gene:	grik1b / 561540	ZFINID:	ZDB-GENE-070821-1	Length:	906	Species:	Danio rerio

Alignment Length:	1010	Identity:	338/1010 - (33%)
Similarity:	510/1010 - (50%)	Gaps:	215/1010 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VGVSAQPSLTEKIPLGAIFEQGTDEVQS----AFKYAMLNHNLN-----VSSRRFELQAYVDVIN 85
            ||:|||    :.:.:|.|||...:|..|    |||:|:.|.|.|     .::..:::|.    ||
Zfish    56 VGLSAQ----QVLRIGGIFETLENEPISVEELAFKFAVTNINRNRTLMPNTTLTYDIQR----IN 112

  Fly    86 TADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFV-TPWFPEKVLTPSSGFLDF 149
            ..|:|:.||..|:|.:.||.::.|.....|...:.|..|..::|.: |.|....|....|    |
Zfish   113 LFDSFEASRRACDQLALGVAAVFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDS----F 173

  Fly   150 ALSMRPDY---HQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVKRISNV 211
            .:::.|||   .:|::|.:|||.|:.:..:|:...||:|||               ||:|..|..
Zfish   174 YINLYPDYASISRAVLDIVQFYKWKAVTVVYEDATGLIRLQ---------------ELIKAPSRY 223

  Fly   212 SMAIEF--LHT--------LEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRT--YHYLLS 264
            |:.|:.  |.|        |:::.:.:...::.||..:.|..:|.|.   |.:|..|  ||:..:
Zfish   224 SIKIKIRQLPTGSKDARPLLKEMKKGKEFCVIFDCSYQTAADVLKQL---LSMGMMTEYYHFFFT 285

  Fly   265 GLVMDDRW--ESEIIEFGAINITGFRIVDTNRRLVREFYDSW--KRLD--PQMSVGAGRESISAQ 323
            .|   |.:  :.|...:..:|:||||:::.:...|....:.|  :||.  |:...|.....::.:
Zfish   286 TL---DLYSLDLEPFRYSGVNMTGFRLLNIDNPQVASVVEKWSMERLQAPPKPETGLQDGMMTTE 347

  Fly   324 AALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGA 388
            ||||||||:::..|               .||.||
Zfish   348 AALMYDAVYMVAAA---------------SQRASQ------------------------------ 367

  Fly   389 GGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFN-DDGRRVN 452
                          :...:|.|:..|    .|..|.:.....::.:..||||.|..| .||.|.:
Zfish   368 --------------ITVSSLQCHRHK----PWRFGSRFISMFKEAQWNGLTGQIIINKTDGLRKD 414

  Fly   453 YTLHVVEM------------TVNSAMVKVAEWNDDAGLQPLNAKYVRLRPHVEFEKNRTYIVTTV 505
            :.|.::.:            ..|....|:..||.:.||...::...:.....:...|||.||||:
Zfish   415 FDLDIISLKEDGLEKPLESGRFNKVWKKIGVWNSNTGLNLTDSNKDKNTNVTDSMANRTLIVTTI 479

  Fly   506 LEEPYIMLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDG 570
            ||.||:|.|:  ..:.|:||:||||||.||...|:..||.:||::||.||.||::...  |.|:|
Zfish   480 LENPYVMYKK--SDKPLYGNDRFEGYCLDLLKELSNILGFSYEVKLVTDGKYGAQNDK--GEWNG 540

  Fly   571 MVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWV 635
            ||.||:...||:|:|.:|||..||:|||||||||:|||||:..||....||||||:||||.:||:
Zfish   541 MVRELIDHVADLAVAPLTITYVREKVIDFSKPFMTLGISILYHKPNGTNPGVFSFLNPLSPDIWM 605

  Fly   636 SVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPG 700
            .|:.:.:|||.|||.::||:|:||.            :||                    |..|
Zfish   606 YVLLACLGVSCVLFVIARFTPYEWY------------NPH--------------------PCNP- 637

  Fly   701 PPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGR 765
                                        .|..|.|.|::.||.||.:.|.||||.:|.|:::|.|
Zfish   638 ----------------------------DSDVVENNFTLINSVWFGVGALMQQGSELMPKALSTR 674

  Fly   766 IAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQI 830
            |....|:|||||:|||||||||||||||||.:||:|.:|||.||:::||.:..|||..||::|:|
Zfish   675 IVGGIWWFFTLIIISSYTANLAAFLTVERMDSPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKI 739

  Fly   831 GLHNKMWEYMNSRKH-VFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDT 894
            ..:.|||.:|:|||: ..|....|||:||..:  .||||:||...||::.|. |:..::|..:|:
Zfish   740 STYEKMWAFMSSRKNTALVKNNREGIQRVLTT--DYALLMESTSIEYISQRN-CNLTQIGGLIDS 801

  Fly   895 KGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETSHSELSLSNVAGI 959
            ||:|:.||:||..:|.:.:|:|.|:|.|:|..::.|||  :......:|.:.: |.|.:.|:.||
Zfish   802 KGYGVGTPIGSPYRDKVTIAILQLQEEGKLHMMKEKWW--RGNGCPEEDSKEA-SALGVENIGGI 863

  Fly   960 FYILIGGLLVSVFVAILEYCFRSR---DSRSASSG 991
            |.:|..||::||||||.|:.::||   |....|.|
Zfish   864 FIVLAAGLVLSVFVAIGEFIYKSRKNLDIEEVSVG 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	114/478 (24%)
		ANF_receptor	55..461	CDD:279440	105/449 (23%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	195/441 (44%)
		Lig_chan	632..967	CDD:278489	126/335 (38%)
grik1b	XP_690040.5	Periplasmic_Binding_Protein_Type_1	62..455	CDD:299141	116/484 (24%)
		ANF_receptor	80..423	CDD:279440	104/434 (24%)
		Periplasmic_Binding_Protein_Type_2	471..840	CDD:304360	195/438 (45%)
		Lig_chan	602..871	CDD:278489	126/335 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590918
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750