Protein Alignment GluRIB and grik1b

DIOPT Version :10

• Sequence 1: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: XP_690040.5
• Gene: grik1b / 561540
• ZFINID: ZDB-GENE-070821-1
• Length: 906
• Species: Danio rerio
• Alignment Length: 1000
• Identity: 334/1000 - (33%)
• Similarity: 513/1000 - (51%)
• Gaps: 195/1000 - (19%)

  Fly    30 VGVSAQPSLTEKIPLGAIFEQGTDEVQS----AFKYAMLNHNLN-----VSSRRFELQAYVDVIN 85
            ||:|||    :.:.:|.|||...:|..|    |||:|:.|.|.|     .::..:::|.    ||
Zfish    56 VGLSAQ----QVLRIGGIFETLENEPISVEELAFKFAVTNINRNRTLMPNTTLTYDIQR----IN 112

  Fly    86 TADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFV-TPWFPEKVLTPSSGFLDF 149
            ..|:|:.||..|:|.:.||.::.|.....|...:.|..|..::|.: |.|....|....|    |
Zfish   113 LFDSFEASRRACDQLALGVAAVFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDS----F 173

  Fly   150 ALSMRPDY---HQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVKRISNV 211
            .:::.|||   .:|::|.:|||.|:.:..:|:...||:|||::.:.  |...|.::: ::::...
Zfish   174 YINLYPDYASISRAVLDIVQFYKWKAVTVVYEDATGLIRLQELIKA--PSRYSIKIK-IRQLPTG 235

  Fly   212 SMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRT--YHYLLSGLVMDDRW-- 272
            |.....|  |:::.:.:...::.||..:.|..:|.|.   |.:|..|  ||:..:.|   |.:
Zfish   236 SKDARPL--LKEMKKGKEFCVIFDCSYQTAADVLKQL---LSMGMMTEYYHFFFTTL---DLYSL 292

  Fly   273 ESEIIEFGAINITGFRIVDTNRRLVREFYDSW--KRLD--PQMSVGAGRESISAQAALMYDAVFV 333
            :.|...:..:|:||||:::.:...|....:.|  :||.  |:...|.....::.:||||||||::
Zfish   293 DLEPFRYSGVNMTGFRLLNIDNPQVASVVEKWSMERLQAPPKPETGLQDGMMTTEAALMYDAVYM 357

  Fly   334 LVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSG 398
            :..|               .||.||
Zfish   358 VAAA---------------SQRASQ---------------------------------------- 367

  Fly   399 GSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFN-DDGRRVNYTLHVVEM-- 460
                :...:|.|:..|    .|..|.:.....::.:..||||.|..| .||.|.::.|.::.:
Zfish   368 ----ITVSSLQCHRHK----PWRFGSRFISMFKEAQWNGLTGQIIINKTDGLRKDFDLDIISLKE 424

  Fly   461 ----------TVNSAMVKVAEWNDDAGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIMLKQ 515
                      ..|....|:..||.:.||...::...:.....:...|||.||||:||.||:|.|:
Zfish   425 DGLEKPLESGRFNKVWKKIGVWNSNTGLNLTDSNKDKNTNVTDSMANRTLIVTTILENPYVMYKK 489

  Fly   516 VAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEA 580
              ..:.|:||:||||||.||...|:..||.:||::||.||.||::...  |.|:|||.||:...|
Zfish   490 --SDKPLYGNDRFEGYCLDLLKELSNILGFSYEVKLVTDGKYGAQNDK--GEWNGMVRELIDHVA 550

  Fly   581 DIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVS 645
            |:|:|.:|||..||:|||||||||:|||||:..||....||||||:||||.:||:.|:.:.:|||
Zfish   551 DLAVAPLTITYVREKVIDFSKPFMTLGISILYHKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVS 615

  Fly   646 IVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAA 710
            .|||.::||:|:||.            :||                    |..|
Zfish   616 CVLFVIARFTPYEWY------------NPH--------------------PCNP----------- 637

  Fly   711 GAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFT 775
                              .|..|.|.|::.||.||.:.|.||||.:|.|:::|.||....|:|||
Zfish   638 ------------------DSDVVENNFTLINSVWFGVGALMQQGSELMPKALSTRIVGGIWWFFT 684

  Fly   776 LILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYM 840
            ||:|||||||||||||||||.:||:|.:|||.||:::||.:..|||..||::|:|..:.|||.:|
Zfish   685 LIIISSYTANLAAFLTVERMDSPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFM 749

  Fly   841 NSRKH-VFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGIATPLG 904
            :|||: ..|....|||:||..:  .||||:||...||::.|. |:..::|..:|:||:|:.||:|
Zfish   750 SSRKNTALVKNNREGIQRVLTT--DYALLMESTSIEYISQRN-CNLTQIGGLIDSKGYGVGTPIG 811

  Fly   905 SALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETSHSELSLSNVAGIFYILIGGLLV 969
            |..:|.:.:|:|.|:|.|:|..::.|||  :......:|.:.: |.|.:.|:.|||.:|..||::
Zfish   812 SPYRDKVTIAILQLQEEGKLHMMKEKWW--RGNGCPEEDSKEA-SALGVENIGGIFIVLAAGLVL 873

  Fly   970 SVFVAILEYCFRSR---DSRSASSG 991
            ||||||.|:.::||   |....|.|
Zfish   874 SVFVAIGEFIYKSRKNLDIEEVSVG 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..480	CDD:380603	112/470 (24%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	195/441 (44%)
		Lig_chan	630..966	CDD:459656	127/336 (38%)
grik1b	XP_690040.5	PBP1_iGluR_Kainate	65..456	CDD:380605	112/472 (24%)
		Periplasmic_Binding_Protein_Type_2	471..840	CDD:473866	195/438 (45%)