Protein Alignment GluRIB and grid1b

DIOPT Version :10

• Sequence 1: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: XP_009304811.1
• Gene: grid1b / 557511
• ZFINID: ZDB-GENE-121214-84
• Length: 1048
• Species: Danio rerio
• Alignment Length: 1205
• Identity: 293/1205 - (24%)
• Similarity: 487/1205 - (40%)
• Gaps: 287/1205 - (23%)

  Fly    42 IPLGAIFEQGTDEVQSAFKYAMLNHNLNVSSRRFE-LQAYVDVINTADAFKLSRLICNQFSRGVY 105
            |.:|||||:........|:.|:.:.:||....:.| :...:..|...:.|:..:..|...::|:.
Zfish    24 IHIGAIFEENAARDDEVFQLAISDLSLNDDILQSEKITHSIKYIEPNNPFQAVQEACELMTQGIL 88

  Fly   106 SMLGAVSPDSFDTLHSYSNTFQMPFV-----TPWFPEKV--LTPSSGFLDFALSMRP-----DYH 158
            :::.:....|...|.|.::...:|.:     ....|...  |.||.....:.|:.||     |..
Zfish    89 ALVTSTGCASASALQSLTDAMHIPHLYVQRNAEGSPRTACQLNPSPDGERYTLAARPPVRLGDVM 153

  Fly   159 QAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVKRISNVSMAIEFLHT--- 220
            ..::..::   |:|.|..|||...:..||....  :...:...|.|.:...|:|.....|.|
Zfish   154 LTLVGELR---WQKFIVFYDSDYDIRGLQVFLD--QTSRQGLDVSLQRVDRNISGVFSSLFTSMR 213

  Fly   221 LEQIGRFEN---KHIVLDCPTEMAKQILIQHVRDLRLGRRTYHYLLSGLVMDDRWESEIIEFGAI 282
            .|::.|:.:   :.|:|..|  ...|:.|....:..|..:..|::   .|.::..::||:|....
Zfish   214 TEELNRYRDTLRRAILLLSP--RGAQVFIHQAVETNLASKDSHWV---FVNEEISDTEILELAHS 273

  Fly   283 NITGFRIVDTNRRLVREFYDSWK-----------RL-----DPQMSVGAGRESISAQAALMYDAV 331
            ::....:       ||:.:..|:           |:     |||...   .:|:......:||:|
Zfish   274 SLGRMTV-------VRQIFPLWRDSSVSCMRNSHRISSLLCDPQEGY---LQSLEVSNLYLYDSV 328

  Fly   332 FVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSD 396
            .:|..||   .||..|:..::
Zfish   329 LMLANAF---YRKLEDRKWHS-------------------------------------------- 346

  Fly   397 SGGSGGMASRALDC--NTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVV- 458
                  |||  |:|  .:.|.|...|    .:...::|..|.||||.:.|.::|...:....::
Zfish   347 ------MAS--LNCIRKSTKPWNGGW----SMLETIQKGRITGLTGIMDFMENGSNSHVQFEILG 399

  Fly   459 ---EMTVNSAMVKVAEWNDDAGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIMLKQVAFGE 520
               ..|....:.::|.|:...||.. :.|..|:...::   ..|..|.|:||:|::|:.:...|:
Zfish   400 TSFSETFGKDIKRLATWDSVHGLNG-SLKESRIENGMQ---GVTVKVVTLLEDPFVMVAENILGQ 460

  Fly   521 KLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIA 585
            .    .|::|:..|:.:.|||.||..|::..|.|..|||:.|  :|.|:||:|||:.|.||:|::
Zfish   461 P----KRYKGFSIDVLEALAKILGFKYDIYQVADSKYGSQLS--NGSWNGMIGELINKRADLAVS 519

  Fly   586 AMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFF 650
            |:|||.|||.|:||||.:|...:.|:.:|| ::...:||...|....:|..:..:...|.:::|.
Zfish   520 AITITPERENVVDFSKRYMDYSVGILHRKP-EEKINIFSLFAPFDLAVWACIAAAIPVVGVLIFL 583

  Fly   651 VSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAAL 715
            ::|          .|..:||:| |.|||
Zfish   584 LTR----------MQMLRSQNP-PGAHH------------------------------------- 600

  Fly   716 QAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILIS 780
                          :|::.|  |:.::.|....||:|||.|....||:.||...||:.||||:.|
Zfish   601 --------------ASSMSN--SLHSAIWIVYGAFVQQGGDSVVGSVALRIVMGSWWLFTLIVCS 649

  Fly   781 SYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRR------SQIGLHNKMWEY 839
            ||||||||||||.||...|.:.:|||.|.:..|||:...:.:|:|:.      .|...:.::|..
Zfish   650 SYTANLAAFLTVSRMDNTIRTFQDLARQMDFAYGTVRDSAVYDYFKAKGTNPLEQDSTYAELWRT 714

  Fly   840 M--NSRKHVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKV-GRNLDTKGFGIAT 901
            :  |:.:...|.:..|||::.:  ||.||.|.:....||....:...|:.| |.::.:||:|||.
Zfish   715 ISKNNGQDFSVSSPSEGIRKAK--KGPYAFLWDMAVVEYAALTDDDCTITVSGNSMSSKGYGIAM 777

  Fly   902 PLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAEC--STHKDGETSHSELSLSNVAGIFYILI 964
            ..||..:|.|:..:|.|:|.|:|..|:.|||.....|  ::|.:.:.....|.|.:.||:|.||.
Zfish   778 QHGSPYRDLISQKILELQEKGDLDVLKQKWWPRTGRCDLNSHSNAQPDGRSLKLHSFAGVFCILA 842

  Fly   965 GGLLVSVFVAILEYCFRSRDSR---------------------------SASSGS---------- 992
            .|||::..||.||..:.|...|                           ::|.||
Zfish   843 AGLLLACLVAALEMWWNSNRCRQEQPKEVTKDYRLARVSGPLTYNDIATASSEGSKDIWTDRERD 907

  Fly   993 ---------GMGLGMGLGGGMSGGSLGKANGSMMLGPSSAVPGGMPSSHQRSTLTDTMHAKAKLT 1048
                     |.|...|.|........|:.:|: ...|.:......|...|        ||.....
Zfish   908 WDEAEAIDTGQGGEPGTGASAFEQPYGRGHGT-QADPRTIYRDLCPGHRQ--------HAAQPAA 963

  Fly  1049 IQASRDYDNGRVGYLNCASLQYYPPAQLS--ATPPDAGDSLHMNAHGQVXHE--HAQESRLXRTP 1109
            ...:|...:|.|    |   ::.||...|  .:..|.|...|.....|. |.  |..:::. :..
Zfish   964 GGCARLPGHGPV----C---EHLPPGASSWGGSDTDPGSWQHPAPSSQQLHHPLHPMQTQGSQRG 1021

  Fly  1110 CAPTIRRIMANSRQETEKMMGGGHGGTVTVSVPAT 1144
            ..||      .|||:|       |...:.:|...|
Zfish  1022 PVPT------ESRQDT-------HANVLPISTRRT 1043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..480	CDD:380603	91/477 (19%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	145/449 (32%)
		Lig_chan	630..966	CDD:459656	101/346 (29%)
grid1b	XP_009304811.1	PBP1_iGluR_delta_1	25..426	CDD:380615	91/480 (19%)
		Periplasmic_Binding_Protein_Type_2	437..809	CDD:473866	144/444 (32%)