Protein Alignment GluRIB and grin2da

DIOPT Version :9

• Sequence 1: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: XP_009292354.1
• Gene: grin2da / 449864
• ZFINID: ZDB-GENE-041008-124
• Length: 1916
• Species: Danio rerio
• Alignment Length: 1043
• Identity: 224/1043 - (21%)
• Similarity: 380/1043 - (36%)
• Gaps: 305/1043 - (29%)

  Fly   231 HIVLDCPTEMAKQILIQHVRDL-----------RLGRRTYHYLLSGLVMDD--RWESEIIEFGAI 282
            ::...|.|::..:::.:.:.:.           ..|...:..::.|::...  .||.:.:..  :
Zfish   192 YLQFSCSTDLQLEVIFEVLEEFDWTAFSVVTTRHHGYEDFLAMVEGMIDGSFIGWERKSVVM--L 254

  Fly   283 NITG-------FRIVDTNRRLVREFYDS----------------------WKRLDPQMSVGAGRE 318
            |:|.       .|::..|...||..|.|                      |..:.|.:| |.|.|
Zfish   255 NLTDDPGGARTRRLLKENEAQVRLLYCSQEEAEQIFKAAWASGQATPSHMWFAVGPGLS-GLGLE 318

  Fly   319 SISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRR-SQTLMVAQAAASTSSDGYNYSASGGG 382
            .:.       .|:|.:          :|..:|:..:|| ::.:.|....|......|
Zfish   319 GLP-------KALFAV----------RPQGWRDEPRRRIAKGVSVLTHGAMALRREY-------- 358

  Fly   383 GGNGGA-GGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKIS------RYLRKVEIEGLTG 440
               ||| |..|||                       |....|::..      |:...:.:.|  .
Zfish   359 ---GGARGTSFAG-----------------------NCMMDGNQTQRVPGRIRFFSNITLSG--R 395

  Fly   441 DIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLNAKY---VRLRPHVE-FEKNRTYI 501
            |..||:||...|..|.|:..|......:|..|.:..    |..:|   .|..|.:: .:.::...
Zfish   396 DYSFNNDGYLANPLLDVISYTAGRGWEEVGWWENGV----LRLRYPPWSRYGPFLKPLDDSQHLR 456

  Fly   502 VTTVLEEPYIMLKQVAFGE----------KLHGNNRF------------EGYCKDLADLLAKELG 544
            |.|:.|.|:::::....|.          :|..||..            :|:|.|:...|||.:|
Zfish   457 VVTLEERPFVIVEPADPGTGSCIRDSVPCRLPLNNSMVVEGIQSMKHCCKGFCIDVLKRLAKIVG 521

  Fly   545 INYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGIS 609
            ..|:|.||.:|.:|   .:..|.|:|||||:|.|.||:||.::||..||..|::||.||:..|||
Zfish   522 FTYDLYLVTNGRHG---KNIDGQWNGMVGEVVSKRADMAIGSLTINEERSEVVEFSVPFVETGIS 583

  Fly   610 IMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIG-VSIVLFFVSRFSPHEWRLVQQQPQQSQSPD 673
            :|:.:. ..|....:|:.|.|..:||.:....:. |::.:|....|||..:.
Zfish   584 VMVSRS-NGTVSPSAFLEPYSPAVWVMMFVMCLSVVAVTVFIFEFFSPVGYN------------- 634

  Fly   674 PHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFS 738
                                                   .:||:..:||.           ::|:
Zfish   635 ---------------------------------------RSLQSGKTAGG-----------SKFT 649

  Fly   739 VWNSFWFSLAAFMQQGCDL-SPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSP 802
            :..|.|...|........: :||..:.:|....|.||.:|.::|||||||||:..|..:..::..
Zfish   650 IGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYIDTVSGL 714

  Fly   803 EDLAMQ--TE----VQYGTLLHGSTWDFFRRSQIGLHNKMWEYM--NSRKHVFVPTYDEGIKRVR 859
            .|...|  ||    :::||:.:|||.:..|.:...:|    :||  |:::.|     ::.|:.::
Zfish   715 SDKKFQHPTEQYPPLRFGTVPNGSTEENIRSNYPNMH----QYMVRNNQRGV-----EDAIENLK 770

  Fly   860 NSKGKYALLVESPKNEYVNAREPCDTMKV--GRNLDTKGFGIATPLGSALKDPINLAVLTLKENG 922
            ..|....:...:..|......|.|..|.:  |:...|.|:|:|....|..|.|::||:|.|..:.
Zfish   771 TGKLDAFIYDAAVLNYMARKDEGCKVMTIGSGKVFATTGYGVALHKNSRWKRPLDLALLQLVGDD 835

  Fly   923 ELIKLRNKWWYEKAECSTHKDG-ETSHSELSLSNVAGIFYILIGGLLVSVFVAILEYCFRSRDSR 986
            |:..|...|.  ...|  |.|. |...|:|.:.|:||:||:|:..:.:|:.|...|:....:...
Zfish   836 EIDMLERLWL--SGIC--HNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWKLRH 896

  Fly   987 SASSGSGMGLGMGLGGGMSGGSLGKANGSMMLGPSSAVPGG----MPSSHQRSTLTDTMHAKAKL 1047
            ......|:...:....||.         |.........|||    :|..|..||:....
Zfish   897 CLGRTRGLDFLLAFSRGMY---------SCCNFEDETAPGGSQSTLPQYHHVSTVPPPP------ 946

  Fly  1048 TIQASRDYDNGRVGYLNCASLQYYPPAQLS---ATPPDAGDSLHMNAHGQVXHEHAQESRLXRTP 1109
                                    ||..:|   |.||.|   :......|. .:|.|:
Zfish   947 ------------------------PPHVISTAVANPPIA---MAQQLPQQQQKQHHQQ------- 977

  Fly  1110 CAPTIRRIMANSRQETEKMMGGGH-------GGTVTVSVPATCSSSMNGSHEGSLAL-----SPS 1162
             .|....::..|..      .|||       ..:..:..|..||:.: ..|:..||:     .|.
Zfish   978 -PPVYSALLPGSPP------SGGHSAMALGPSNSPILGAPMPCSTFL-PRHDRRLAVVDRWTRPK 1034

  Fly  1163 SGS 1165
            .||
Zfish  1035 VGS 1037

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	51/296 (17%)
		ANF_receptor	55..461	CDD:279440	48/279 (17%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	119/474 (25%)
		Lig_chan	632..967	CDD:278489	80/347 (23%)
grin2da	XP_009292354.1	PBP1_iGluR_NMDA_NR2	42..441	CDD:107373	53/308 (17%)
		PBP2_iGluR_NMDA_Nr2	452..851	CDD:270436	120/478 (25%)
		HisJ	<507..>590	CDD:223904	39/86 (45%)
		Lig_chan	605..877	CDD:278489	80/347 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810