DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and grid2

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_001004123.1	Gene:	grid2 / 448841	ZFINID:	ZDB-GENE-040913-1	Length:	1009	Species:	Danio rerio

Alignment Length:	1061	Identity:	253/1061 - (23%)
Similarity:	444/1061 - (41%)	Gaps:	279/1061 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LWPSFLLWLT-WSSGGGGGSGVGVSAQPSLTEK-IPLGAIFEQGTDEVQSAFKYAMLNHNLNVSS 72
            ::|:.|..:| ||          :..:|.|.:. |.:||||::...:....|:.|:.:.|||...
Zfish     3 VFPAVLFLITFWS----------LEWEPVLPDSIIHIGAIFDESAKKDDEVFRMAVADLNLNNEI 57

  Fly    73 RRFE-LQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFP 136
            ...| :...|:.::..:.|:..:..|...:||:.:::.::...|..:|.|.::...:|.:   |.
Zfish    58 LETEKITVSVEFVDGNNPFQAVQEACELMNRGILALVSSIGCMSAGSLQSLADAMHIPHL---FI 119

  Fly   137 EKVL--TPSSGFL--------DFALSMRPDYH--QAIIDTIQFYGWRKIIYLYDSHDGLLRLQQI 189
            ::..  ||.|...        |:.|.:||..:  ..|...:..|.|:|.|..||:...:..::..
Zfish   120 QRAPAGTPRSSCPPTTRAQPDDYTLFVRPPVYLNDVIFQVVMEYTWQKFIIFYDTDYDIRGIENF 184

  Fly   190 YQGLRPGNESFQVELVKRISNVSMAI---------EFLH----TLEQIGRF-------------- 227
            ..  :...:...|.|.|..||::|.|         |.||    ||.:...|
Zfish   185 LD--QTSQQGMDVSLQKVESNINMMITGMFRTMRVEELHRYRDTLRRAVLFMSPATAKAFITEVV 247

  Fly   228 ENKHIVLDCP--------TEM-AKQILIQHVRDLRLGRRTYHYLLSGLVMDDRWESEIIEFGAIN 283
            |...:..||.        ::| .::::::.:..|.|.|:|                    |....
Zfish   248 ETNLVAFDCQWIIINEEISDMDVQELVMKSIGRLTLVRQT--------------------FPLPQ 292

  Fly   284 ITGFRIVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFVLVEAFNKILRKKPDQ 348
            .|..|.|..|.|:.....|.   .||:      .:.:......:||.|.:|...|:   ||..|:
Zfish   293 NTSQRCVRNNHRINTSLCDP---KDPK------AQMLEITNRYIYDTVLLLANTFH---RKLEDR 345

  Fly   349 FRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDCNTA 413
            ..::                                                  |||  |.| ..
Zfish   346 KWHS--------------------------------------------------MAS--LSC-IR 357

  Fly   414 KGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVN------SAMVKVAEW 472
            || ...|:.|..:...::|..:.|||..::|||:|...|  :|...:..|      ..:.::|.|
Zfish   358 KG-SKPWQGGKSMLETVKKGGVSGLTSLLEFNDNGSNPN--IHFEILGTNYGEDRGRGVSRLATW 419

  Fly   473 NDDAGLQPL--------NAKYVRLRPHVEFEKNRTYIVTTVLEEPYIMLKQVAFGEKLHGNNRFE 529
            :...||...        |.:.|.||            |.||||||::|:.:...|:.    .:::
Zfish   420 DPIHGLNGTLTDRKLENNMRGVVLR------------VVTVLEEPFVMVSENVLGKP----KKYQ 468

  Fly   530 GYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITAERE 594
            |:..|:.|.||..||..||:.:..|..|||::  |.|.|:|::||||.|.||:.::|:|||.|||
Zfish   469 GFSIDVLDALANYLGFKYEIYVAPDHKYGSQQ--ADGTWNGLIGELVFKRADVGLSALTITPERE 531

  Fly   595 RVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSPHEW 659
            .|:||:..:|...:.::::| .::|..:|:.:.|....:|..:..:.:.|..:::.::..:|
Zfish   532 SVVDFTTRYMDYSVGVLLRK-AERTVDMFACLAPFDLSLWACIAGTVLLVGTLVYLLNWLNP--- 592

  Fly   660 RLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSP 724
                  |:                                                   |..||
Zfish   593 ------PR---------------------------------------------------LPMGS- 599

  Fly   725 GSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTANLAAF 789
                     |:..:::||.||...:|:|||.::...:::.|:....|:.|.||:|||||||||||
Zfish   600 ---------VSSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGVWWLFALIVISSYTANLAAF 655

  Fly   790 LTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIG------LHNKMWEYMN--SRKHV 846
            ||:.|:...|.|.:|||.||::.|||:|..:.:|..|...:.      ::::||..:|  .....
Zfish   656 LTISRIENSIQSLQDLAKQTDLPYGTVLDSAVYDQVRSKGMNPFERDPMYSQMWRMINRTGGAEN 720

  Fly   847 FVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAR-EPCDTMKVGRNLDTKGFGIATPLGSALKDP 910
            .|....|||::|:  .|::|.:.::...|||... |.|....|..|:..:|:|:|...||..:|.
Zfish   721 NVEESKEGIRKVK--YGRFAFVWDAAVLEYVAINDEDCSLYTVSNNVADRGYGMAMQHGSPYRDI 783

  Fly   911 INLAVLTLKENGELIKLRNKWWYEKAEC------STHKDGETSHSELSLSNVAGIFYILIGGLLV 969
            .:..:|.|::||::..|:.|||...:.|      .|.|.|    |.|.:.:.||:|::|..|:::
Zfish   784 FSQRILELQQNGDMDILKLKWWPRDSPCDLYSPVGTRKSG----SALDIHSFAGVFFVLAAGVVL 844

  Fly   970 SVFVAILE-YCFRSRDSRSAS 989
            |..:|.:| :..|.:.||..|
Zfish   845 SCLIATVETWWTRRKGSRVPS 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	94/489 (19%)
		ANF_receptor	55..461	CDD:279440	87/454 (19%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	127/449 (28%)
		Lig_chan	632..967	CDD:278489	89/349 (26%)
grid2	NP_001004123.1	PBP1_iGluR_delta_2	28..427	CDD:107386	96/491 (20%)
		ANF_receptor	42..404	CDD:279440	87/454 (19%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	129/456 (28%)
		Lig_chan	568..841	CDD:278489	89/348 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	989..1009
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810