DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and KaiR1D

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster

Alignment Length:	987	Identity:	323/987 - (32%)
Similarity:	502/987 - (50%)	Gaps:	212/987 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SLTEKIPLGAIFEQGTDEVQSAFKYAM--LNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQ 99
            ||.:.|.:|.:|....|..:.||:.|:  :|.:.::..|. :|.|.::.|:..|:|...:.:|..
  Fly    25 SLPDIIKIGGLFHPADDHQELAFRQAVDRINADRSILPRS-KLVAQIERISPFDSFHAGKRVCGL 88

  Fly   100 FSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLTPSSGFLDFALSMRPDYH------ 158
            .:.||.::.|..|..:...:.|..:..::|.                    |..|.||.
  Fly    89 LNIGVAAIFGPQSSHTASHVQSICDNMEIPH--------------------LENRWDYRLRRESC 133

  Fly   159 ------------QAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQ--GLRPGNESFQVELVKRIS 209
                        :|.:|.::.:||:....:|:::||::|||::.:  |:.|    |.: .|:::|
  Fly   134 LVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTP----FPI-TVRQLS 193

  Fly   210 NVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRT-YH-YLLSGLVMDDRW 272
            :..   ::...|:||......||||||.||...::|.|   ..::|..: || ||::.|   |..
  Fly   194 DSG---DYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQ---AQQIGMMSDYHSYLVTSL---DLH 249

  Fly   273 ESEIIEF--GAINITGFRIVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFVLV 335
            ...:.||  |..||||||::  |.::|.:....|...:..:...|...::.::.|||||||.:..
  Fly   250 TVNLDEFRYGGTNITGFRLI--NEKIVSDVVRQWSIDEKGLLRSANLTTVRSETALMYDAVHLFA 312

  Fly   336 EAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGS 400
            :|.:.:                        ..|...|.:..|..|
  Fly   313 KALHDL------------------------DTSQQIDIHPISCDG-------------------- 333

  Fly   401 GGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVNSA 465
                            .:.|:||..:..|::.||::|||..|||:..|.|.::.|.:||:| .:.
  Fly   334 ----------------QSTWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVELT-PAG 381

  Fly   466 MVKVAEWNDDAGLQPLNAKYVRL--RPHVEFE---KNRTYIVTTVLEEPYIMLKQVAFGEKLHGN 525
            :.|:..||...   |....:.|.  :...|.|   ||:|.:|||:|..||.|.|:.|.  .|.||
  Fly   382 IRKIGTWNSTL---PDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAI--PLSGN 441

  Fly   526 NRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTIT 590
            ::||||..||...::|.||.||:::||.||:||| .:...|.|:||:.||:.:.||:|||.:|||
  Fly   442 DQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGS-LNKLTGEWNGMIRELLEQRADLAIADLTIT 505

  Fly   591 AERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFS 655
            .|||:.:||:.|||:||:||:.:||:||.|.:|||::|||.::|:.:..:|:|||::||.:::|:
  Fly   506 FEREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFT 570

  Fly   656 PHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALS 720
            |:||      |..:.     ||.|::.:|
  Fly   571 PYEW------PAYTD-----AHGEKVESQ------------------------------------ 588

  Fly   721 AGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTAN 785
                            |::.|..||::.:.||||||..|:::|.|:.|..|:|||||:|||||||
  Fly   589 ----------------FTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTAN 637

  Fly   786 LAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYMNS-RKHVFVP 849
            ||||||||||.:||.|.||||.||.::||.|..|||..|||.|:|..:.:||.:|.| |..||..
  Fly   638 LAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTA 702

  Fly   850 TYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGIATPLGSALKDPINLA 914
            :..||::||...||.||.|:||...|||..|. |:..:||..||||.:|||||..|..:..||..
  Fly   703 SNGEGVERVAKGKGSYAFLMESTSIEYVTERN-CELTQVGGMLDTKSYGIATPPNSPYRTAINSV 766

  Fly   915 VLTLKENGELIKLRNKWWYEK---AECSTHKDGETSHS-----ELSLSNVAGIFYILIGGLLVSV 971
            :|.|:|.|:|..|:.|||.||   .:|..    |||.|     ||.|:||.|:|.:|:||:.|:.
  Fly   767 ILKLQEEGKLHILKTKWWKEKRGGGKCRV----ETSKSSSAANELGLANVGGVFVVLMGGMGVAC 827

  Fly   972 FVAILEYCFRSR 983
            .:|:.|:.::||
  Fly   828 VIAVCEFVWKSR 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	105/460 (23%)
		ANF_receptor	55..461	CDD:279440	98/431 (23%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	190/444 (43%)
		Lig_chan	632..967	CDD:278489	135/343 (39%)
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	106/466 (23%)
		ANF_receptor	42..378	CDD:279440	98/432 (23%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	187/436 (43%)
		Lig_chan	547..823	CDD:278489	135/343 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	169	1.000	Inparanoid score	I1556
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.860