Protein Alignment GluRIB and Nmdar1

DIOPT Version :9

• Sequence 1: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Alignment Length: 1156
• Identity: 266/1156 - (23%)
• Similarity: 448/1156 - (38%)
• Gaps: 339/1156 - (29%)

  Fly    44 LGAIFEQGTDEVQSAFKYAMLNHNLNVSSRRFELQAYVD------------VINTADAFKLSRLI 96
            :|.:......|...:.....||.:.....|:.   .|.|            |.|..|     :||
  Fly    41 IGGVLSNSDSEEHFSTTIKHLNFDQQYVPRKV---TYYDKTIRMDKNPIKTVFNVCD-----KLI 97

  Fly    97 CNQFSRGVYSML-------GAVSPDSFDTLHSYSNTF-QMPFVTPWFPEKVLTPSSGFLDFALSM 153
            .|:    ||:::       |.:||.:.    ||::.| .:|.:.....:...:..:..:.|..::
  Fly    98 ENR----VYAVVVSHEQTSGDLSPAAV----SYTSGFYSIPVIGISSRDAAFSDKNIHVSFLRTV 154

  Fly   154 RPDYHQAII--DTIQFYGWRKIIYLYDSH-DGLLRLQQIYQGLRPGNESFQVELVKRISNVSMA- 214
            .|.||||.:  :.:..:.:.|:|.::.|. ||.                   .::.|....|..
  Fly   155 PPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGR-------------------AILGRFQTTSQTY 200

  Fly   215 ---IEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGR-RTYHYLLSGLVMDDRWESE 275
               ::...|:|.|..||.|   |:..||        |:.|::..: |.|      |:.....:::
  Fly   201 YDDVDVRATVELIVEFEPK---LESFTE--------HLIDMKTAQSRVY------LMYASTEDAQ 248

  Fly   276 II--EFGAINITG---FRIVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFVLV 335
            :|  :.|..|:||   ..|| |.:.|       :....|...:|...|...:....:.|:|:||.
  Fly   249 VIFRDAGEYNMTGEGHVWIV-TEQAL-------FSNNTPDGVLGLQLEHAHSDKGHIRDSVYVLA 305

  Fly   336 EAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGS 400
            .|..:::..:               .:|:|.                            .|.|.|
  Fly   306 SAIKEMISNE---------------TIAEAP----------------------------KDCGDS 327

  Fly   401 GGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRV--NYTL-------- 455
            .               || ||.|.::.:||:...|.|.||.:.|:|:|.|:  .|.:
  Fly   328 A---------------VN-WESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQK 376

  Fly   456 -HVV-EMTVNSAMVKVAEWNDDA-----GLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIML 513
             ||| :.:.:|...|:....:|:     |.|....:.:.:..|:.        :.|:.|:|::.:
  Fly   377 KHVVGKFSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIPTHLR--------LLTIEEKPFVYV 433

  Fly   514 KQVAFGE----------KLHGN-----NRF--EGYCKDLADLLAKELGINYELRLVKDGNYGSEK 561
            :::...|          .|..|     |.|  .|||.||...|:|.:...|:|.|..||.:|...
  Fly   434 RRMGDDEFRCEPDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYI 498

  Fly   562 SSAHGG-------WDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQT 619
            ...:.|       |.|::||||.:.||:.:|.:||..||...|:|||||...||:|:.|||.:.:
  Fly   499 LRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSS 563

  Fly   620 PGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSPH-EWRLVQQQPQQSQSPDPHAHHEQLAN 683
            . :.||:.|.|..:|:.|:.|...|::||:.:.||||. .::|              :|.:  :|
  Fly   564 T-LVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKL--------------SHSD--SN 611

  Fly   684 QQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLA 748
            :                               :.||:.        ||||          ||:..
  Fly   612 E-------------------------------EKALNL--------SSAV----------WFAWG 627

  Fly   749 AFMQQGC-DLSPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQ 812
            ..:..|. :.:|||.|.|:....|..|.:|:::||||||||||.:||..|.::...|..::..::
  Fly   628 VLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTME 692

  Fly   813 YGT--LLHGSTWDFFRRSQIGLHNKMWEYMNSRKHVFVPTYDEGIKRVRNSKGK-YALLVESPKN 874
            ..|  .:.||:.|.:.|.|:.|.| |:..|.:..:.   |.::.|:.|:  ||| .|.:.:|.:.
  Fly   693 NLTCATVKGSSVDMYFRRQVELSN-MYRTMEANNYA---TAEQAIQDVK--KGKLMAFIWDSSRL 751

  Fly   875 EYVNAREPCDTMKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYE---KA 936
            || .|.:.|:.:..|......|:||....||...|.:.||:|...|:|.:.||..:|.:.   :.
  Fly   752 EY-EASKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQ 815

  Fly   937 ECSTHKDGETSHSELSLSNVAGIFYILIG-GLLVSVFVAILEYCFR------------------- 981
            .|...   |.:.:.|.|.|:||:| ||:| |:...|.:.|:|..::
  Fly   816 NCELF---EKTPNTLGLKNMAGVF-ILVGVGIAGGVGLIIIEVIYKKHQVKKQKRLDIARHAADK 876

  Fly   982 ------SRDSRSASSGSGMGLGMGLGGGMSGGSLGKA-------NGSMMLGPSSAVPGGMPSSHQ 1033
                  .|.:..||........:||....:.|::..|       .....|||..|.||
  Fly   877 WRGTIEKRKTIRASLAMQRQYNVGLNSTHAPGTISLAVDKRRYPRLGQRLGPERAWPG------- 934

  Fly  1034 RSTLTDTMHAKAKLTIQASRDYDNGRVGY---LNCASLQYYPPAQLSATPP 1081
                      .|...::..|.|:.|..|.   :..|:....|...|..|.|
  Fly   935 ----------DAADVLRIRRPYELGNPGQSPKVMAANQPGMPMPMLGKTRP 975

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	93/483 (19%)
		ANF_receptor	55..461	CDD:279440	88/450 (20%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	132/472 (28%)
		Lig_chan	632..967	CDD:278489	92/343 (27%)
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	93/482 (19%)
		ANF_receptor	58..371	CDD:279440	85/431 (20%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	133/481 (28%)
		HisJ	451..>558	CDD:223904	40/106 (38%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	54/200 (27%)
		Lig_chan	575..838	CDD:278489	89/338 (26%)
		CaM_bdg_C0	854..882	CDD:287524	0/27 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462563
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	169	1.000	Inparanoid score	I1556
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.990