DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and gria1b

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_991293.1	Gene:	gria1b / 403044	ZFINID:	ZDB-GENE-020125-2	Length:	917	Species:	Danio rerio

Alignment Length:	1046	Identity:	423/1046 - (40%)
Similarity:	569/1046 - (54%)	Gaps:	194/1046 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LWPSFLLWLTWSSGGGGGSGVGVSAQPSLTEKIPLGAIFEQGTDEVQSAFKYAMLNHNLNVSSRR 74
            :|.||:|.||        ..:|:.:..|....|.:|.:|...:.| ...|::|:..|| :|.
Zfish     1 MWQSFVLLLT--------GLLGLCSCSSFPSNINIGGLFPTDSHE-YDVFRFALSQHN-DVP--- 52

  Fly    75 FELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKV 139
             :|...||:::|..:|.::...|:|||:|||:::|.....:.:.|.|:.....:.||||.||
Zfish    53 -KLVPQVDMVDTGSSFAMTYAFCSQFSKGVYAIIGLYDRKTMNMLMSFCGALHVCFVTPSFP--- 113

  Fly   140 LTPSSGFLD----FALSMRPDYHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESF 200
                   :|    |.:.:||:...|:|..::.|.|.|.:|:|.|..||..||:|..  ....:::
Zfish   114 -------IDTNNQFVIQLRPELQDALIALVEHYKWNKFVYMYSSDSGLTVLQKILD--TAAEKTW 169

  Fly   201 QVELVKRISNVSMAIE--FLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRTYHYLL 263
            ||..:    |.....|  ||..::.:...:...|:|||..|....|| ..:...:...:.|||:|
Zfish   170 QVTSI----NFDTLTEAAFLKAIQDLDNKKEFKIILDCELERLNSIL-NLIAAQKKNLKNYHYIL 229

  Fly   264 SGLVMDDRWESEIIEF--GAINITGFRIVD-TNRRLVREFYDSWKRLDPQMSVGAGRESISAQAA 325
            :.|...|   ..:.||  |..|:|||:::: ||..:.|...| |...|.: .:.:.:..:....|
Zfish   230 ANLGFLD---LNLTEFRKGGANVTGFQLMNYTNPTVSRTIQD-WLEFDSK-DLKSPKRRLKYTGA 289

  Fly   326 LMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGG 390
            |.||.|.|:..||.. |||:    |.::.||                             |.||.
Zfish   290 LTYDGVTVMATAFQN-LRKQ----RIDISRR-----------------------------GNAGE 320

  Fly   391 GFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTL 455
            ..|...:                     .|..|..|.|.|::|:.|||||.::|||.|.|.|:|:
Zfish   321 CLANPPA---------------------PWGQGIDIQRALQQVQFEGLTGHVQFNDKGHRTNFTV 364

  Fly   456 HVVEMTVNSAMVKVAEWNDDAGLQPLNAKYVRLRPHVEF------EKNRTYIVTTVLEEPYIMLK 514
            .|:|.. .|...||..||.       ..|||....:...      .:||||:|||:||.||:|||
Zfish   365 SVMEFG-PSGPKKVGYWNQ-------REKYVSTATYSNMLNETFGLQNRTYVVTTILEAPYVMLK 421

  Fly   515 QVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKE 579
            :  ..|:|.||:::||||.:||..:||.:|.:|.|.||.||.||:..:... .|:|||||||..:
Zfish   422 K--NHEQLVGNDKYEGYCVELAAEIAKHVGYSYRLELVGDGKYGARDAETM-MWNGMVGELVYGK 483

  Fly   580 ADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGV 644
            ||:|:|.:|||..||.||||||||||||||||||||.|..||||||::||:.|||:.::|:||||
Zfish   484 ADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPTKSKPGVFSFLDPLAYEIWMCIVFAYIGV 548

  Fly   645 SIVLFFVSRFSPHEWR-------LVQQQPQQSQSPDPHAHHEQLANQ-------QPPGIIGGAPL 695
            |:|||.||||||:||.       ..||...|..||:|:....|..||       ||..
Zfish   549 SVVLFLVSRFSPYEWHADDEEETADQQNQNQPPSPEPNQSPNQSQNQREEKQEKQPEH------- 606

  Fly   696 PAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPR 760
                                                  .|||.::||.||||.||||||||:|||
Zfish   607 --------------------------------------TNEFGIFNSLWFSLGAFMQQGCDISPR 633

  Fly   761 SVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFF 825
            |:||||....|:|||||:||||||||||||||||||:||.|.||||.|||:.||||..|||.:||
Zfish   634 SLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDGGSTKEFF 698

  Fly   826 RRSQIGLHNKMWEYMNSRK-HVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVG 889
            |||:|.:..|||.||.|.: .|||.|.|||:.|||.||||||.|:||..|||:..|:||||||||
Zfish   699 RRSKIAVFEKMWSYMKSAEPTVFVKTTDEGVVRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVG 763

  Fly   890 RNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAEC-STHKDGETSHSELSL 953
            .|||:||:|:|||.||||::|:|||||.|.|.|.|.||:|||||:|.|| |...|.:...|.|||
Zfish   764 GNLDSKGYGVATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSL 828

  Fly   954 SNVAGIFYILIGGLLVSVFVAILEYCFRSR-DSR------SASSGSGMGLGMGLGGGMSGGSLGK 1011
            |||||:||||||||.:::.||::|:|::|| :||      .|:..|.....||.||
Zfish   829 SNVAGVFYILIGGLGLAMLVALVEFCYKSRIESRRMKQIIDAAMLSSTLTRMGSGG--------- 884

  Fly  1012 ANGSMM 1017
            .||.:|
Zfish   885 ENGRVM 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	121/443 (27%)
		ANF_receptor	55..461	CDD:279440	113/414 (27%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	252/455 (55%)
		Lig_chan	632..967	CDD:278489	190/350 (54%)
gria1b	NP_991293.1	PBP1_iGluR_AMPA_GluR1	26..387	CDD:107385	122/451 (27%)
		ANF_receptor	41..368	CDD:279440	112/408 (27%)
		PBP2_iGluR_AMPA_GluR1	404..812	CDD:270447	252/455 (55%)
		Lig_chan	536..842	CDD:278489	190/350 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590915
Domainoid	1	1.000	371	1.000	Domainoid score	I851
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	698	1.000	Inparanoid score	I657
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D89427at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm6377
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770