DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and GluRIA

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster

Alignment Length:	1087	Identity:	704/1087 - (64%)
Similarity:	828/1087 - (76%)	Gaps:	141/1087 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SCLWPSFLLWLTWSSGGGGGSGVGVSAQP-----SLTEKIPLGAIFEQGTDEVQSAFKYAMLNHN 67
            |..||.|                 .|||.     |||||||||||||||||:|||||||||||||
  Fly    18 SIFWPEF-----------------SSAQQQQQTVSLTEKIPLGAIFEQGTDDVQSAFKYAMLNHN 65

  Fly    68 LNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVT 132
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly    66 LNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVT 130

  Fly   133 PWFPEKVLTPSSGFLDFALSMRPDYHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGN 197
            ||||||||.||||.||||:|||||||||||||||:|||:.|||||||||||||||||||.|:|||
  Fly   131 PWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGN 195

  Fly   198 ESFQVELVKRISNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRTYHYL 262
            |:|:|::||||:||:||||||||||.:|||..|.||||||.||||:|::|||||::|||||||||
  Fly   196 ETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYL 260

  Fly   263 LSGLVMDDRWESEIIEFGAINITGFRIVDTNRRLVREFYDSWKRLDP---QMSVGAG----RESI 320
            |||||||:.|.|:::||||||||||||||:|||.||:|:||.|||:|   ..|..||    ..:|
  Fly   261 LSGLVMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAI 325

  Fly   321 SAQAALMYDAVFVLVEAFNKILRKKPDQFR-NNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGG 384
            |||||||||||||||||||:|||||||||| |::||||.     ..::|:|:.|.|.|
  Fly   326 SAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSH-----GGSSSSSATGTNES------- 378

  Fly   385 NGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGR 449
                                |..|||||:||||..||.|:||||.||||||:||:|:|:|::|||
  Fly   379 --------------------SALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGR 423

  Fly   450 RVNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLNA-KYVRLRPHV-----EFEKNRTYIVTTVLEE 508
            |:|||||||||:|||.:.:||||.|||||.||:: .|.......     ::::|.||||:::|||
  Fly   424 RINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEE 488

  Fly   509 PYIMLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVG 573
            ||:.|||..:||.|.||:|||||||||||:||.:|||.||:|||:|||||:|...|.||||||||
  Fly   489 PYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVG 553

  Fly   574 ELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVI 638
            ||:||||||||:|||||||||||||||||||:||||||||||||||||||||:||||||||:|||
  Fly   554 ELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVI 618

  Fly   639 FSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPG--P 701
            .||:|||.||:||:||.|:|||:| ::||...:.           ||||||||||.|..|..  |
  Fly   619 LSYVGVSFVLYFVTRFPPYEWRIV-RRPQADSTA-----------QQPPGIIGGATLSEPQAHVP 671

  Fly   702 PTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRI 766
            |.|                             .|||::.||||:|||||||||||::|.|::|||
  Fly   672 PVP-----------------------------PNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRI 707

  Fly   767 AAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIG 831
            |||.|:|||:||||||||||||||||||||.||.:||||.|||:|.|||||:||||:||||||||
  Fly   708 AAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIG 772

  Fly   832 LHNKMWEYMNSRKHVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKG 896
            ||||||||||:.:|..|.||||||:|||.||||||||||||||||||||.||||||||||:||||
  Fly   773 LHNKMWEYMNANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKG 837

  Fly   897 FGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETS-HSELSLSNVAGIF 960
            ||:|||:||.|:..:|.|||||||||||:::|||||::|.||:.  |.||| .:||||||||||:
  Fly   838 FGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNL--DQETSTPNELSLSNVAGIY 900

  Fly   961 YILIGGLLVSVFVAILEYCFRSRDSRSASSGSGMGLGMGLGGGMSGGSLGKANGSMMLGPSSAVP 1025
            ||||||||::|.|||:|:..|::..:..|.||         .|.:||                ||
  Fly   901 YILIGGLLLAVIVAIMEFFCRNKTPQLKSPGS---------NGSAGG----------------VP 940

  Fly  1026 GGMPSS-HQRSTLTDT-MHAKAKLTIQASRDYDNGRVGYLNCASLQY 1070
            |.:.|| :||.:|:|. ||::|||.:|||.:||...||....::::|
  Fly   941 GMLASSTYQRDSLSDAIMHSQAKLAMQASSEYDERLVGVELASNVRY 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	323/442 (73%)
		ANF_receptor	55..461	CDD:279440	301/413 (73%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	305/442 (69%)
		Lig_chan	632..967	CDD:278489	218/337 (65%)
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	324/443 (73%)
		ANF_receptor	53..434	CDD:279440	300/412 (73%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	305/442 (69%)
		Lig_chan	612..907	CDD:278489	218/337 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470308
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	1	1.000	-	-		H37353
Inparanoid	1	1.050	169	1.000	Inparanoid score	I1556
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D89427at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm6377
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	12	11.810